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Indianapolis Colts emerged victorious with a 201.00-161.54 win to hand New York Giants their sixth straight loss to open the season. New York Giants earned a 4.24-point lead on Thursday, but Indianapolis Colts held the lead the rest of the way. They were led by Jameis Winston, who passed for 395 yards and 4 touchdowns and ran for 31 yards for 40.9 points, and DeAndre Hopkins, who caught 5 passes for 63 yards and a touchdown (17.3 points). Bradley Chubb (19.5 points) and Desmond King II (18) did their part for New York Giants in the loss. Indianapolis Colts (4-2) will look to notch another W against NE Patriots, while New York Giants (0-6) match up against Minnesota Vikings in an effort to right the ship.