Kirk Cousins is primed for another huge performance against a Browns team that's allowing 294.3 passing yards per contest, considering that he has surpassed that mark in every game this season.
Ezekiel Elliott rushed for 140 yards on 30 carries last week, and will get the ball early and often again facing the 49ers' 23rd-ranked run defense Sunday.
Greg Olsen had an “off” week last week (six receptions, 64 yards), but he has a Week 4 matchup against a Falcons defense that’s allowed four touchdowns to opposing tight ends this season.
DeSean Jackson's big play ability makes him a strong play Sunday against a 25th-ranked Browns pass defense that has given up more than its fair share of long gains.
Melvin Gordon scored his fourth TD of the season in Week 3 and gets a premium matchup Sunday at home against a Saints defense allowing a league-worst 149.3 rushing yards per game so far.
Terrelle Pryor will face Washington on Sunday, and it’s possible that he’ll continue to see snaps as a Wildcat quarterback, which could give him major upside this week.
Josh Lambo connected on three field goals in Week 3 and gets a very favorable matchup Sunday at home against a Saints defense that's allowed 32.0 points per game so far, second-worst in the league.
Matthew Stafford has topped 330 yards while throwing for three touchdowns in two games this season, and faces a Bears defense that is surrendering 27.7 points per game.
DeAndre Hopkins and the rest of the Houston offense had a tough Week 3 and will look to get back in the win column against a disappointing Tennessee Titans, who have allowed 186 yards per game to wide receivers.
A.J. Green has a Thursday matchup against a Dolphins’ defense that coughed up eight receptions for 144 yards to Terrelle Pryor last week.
Travis Benjamin has averaged 19.7 yards per catch over the last two games and should be explosive once again Sunday at home against a Saints defense allowing nearly 300 passing yards a game so far.
Jordan Reed has been relatively quiet thus far, but could break out Sunday against a Browns team that ranks 25th in defending the pass.
Antonio Brown will face the Chiefs on Sunday night after torching this defense for 124 last year in a game that backup quarterback Landry Jones started.
Jamison Crowder already has 16 catches for 175 yards and two touchdowns this season, and likely won't slow down Sunday against a Browns team allowing 294.3 passing yards per game.
Dan Bailey missed one against Chicago, but should be able to rebound Sunday against a 49ers team that has been unimpressive since a Week 1 shutout.
Jordan Howard has an inviting matchup against a Lions defense which is allowing a league-high 5.1 yards per carry, and would see a boost in his appeal should Jeremy Langford (ankle) miss the contest.
Todd Gurley should be able to follow last week's two-touchdown performance with another strong game Sunday against a Cardinals defense that ranks 29th against the run.
Lamar Miller has been Houston's workhorse through the first three games, ranking second among running backs with 74 carries, and will carry the load once again in Week 4 against the Tennessee Titans, who rank 17th in rushing defense.
T.Y. Hiltons' breakout in Week 3 was a welcome sign and points to similar production in Week 4 against the Jacksonville Jaguars, who have been stout against the pass but have allowed 35 catches for 714 yards to Hilton in eight career games.
Kyle Rudolph has seen eight targets or more in all three games this season, catching two touchdowns, but faces a Giants defense Monday night that has yet to allow a tight end to reach the end zone.
Isaiah Crowell has a Sunday contest against a Washington defense that has allowed six touchdowns to running backs through three games this season.
Jeremy Hill has a Thursday matchup against a Dolphins’ defense that allowed 123 rushing yards to LaGarrette Blount in Week 2 and then 148 yards to the Browns’ duo of Isaiah Crowell and Duke Johnson last week.
Joe Flacco will be at home to take on a Raiders’ defense that he had 384 passing yards and two touchdowns against when facing them in 2015.
Drew Brees threw his first pick in more than 300 pass attempts on Monday night, but he'll look to get back on track in Week 4 against a Chargers defense that’s allowed 329 or more passing yards in each of the first three weeks.
Justin Tucker will take on the Raiders in Week 4 after making all nine of his field goal attempts over the first three weeks of the season.
Marvin Jones is averaging 22.7 yards per catch and has popped for at least one catch of 30-plus yards every week heading into a matchup against a Bears defense that is allowing only 214 yards per game through the air.
Dak Prescott has scored on the ground in back-to-back games, which makes him a solid Week 4 option against a 49ers team that has struggled to contain dual-threat quarterbacks.
Andrew Luck's overall play remains spotty to start the 2016 season, but he remains dangerous entering Week 4 as the Colts face the winless Jacksonville Jaguars, whose coach may be the first to be fired in 2016.
Carson Palmer will look to bounce back from last week's four-interception performance Sunday against a Rams team that he carved up for over 350 yards in both 2015 meetings.
Allen Robinson asserted himself in the offense in Week 3 (two TDs) and looks to continue that in Week 4 against the Indianapolis Colts, who rank 30th in scoring defense.
Cole Beasley doesn't make many big plays, but rookie quarterback Dak Prescott should continue to look for him early and often Sunday against the 49ers after completing 20 passes for 213 yards to him through three weeks.
Dennis Pitta will face a Raiders’ defense on Sunday that has allowed at least 59 receiving yards to three different tight ends this season.
John Brown will look to follow last week's 70-yard performance with another strong effort Sunday against a Rams team that gave up 94 yards per game to him last season.
DeMarco Murray, more than anyone else on the Titans' roster, is a sure play in Week 4 against the Houston Texans, who rank 27th in rushing defense.
Pierre Garcon has been outplayed by both DeSean Jackson and Jamison Crowder among Redskins wide receivers, but could still put up big numbers Sunday against Cleveland's 25th-ranked pass defense.
Mike Wallace have a Sunday contest against the Raiders who have allowed three different wide receivers to post at least 106 yards and a touchdown against them in 2016.
After missing last week with a toe injury, Willie Snead will look to return on Sunday against the Chargers, who’ve allowed 325 or more passing yards to each of their first three opponents.
Fozzy Whittaker will look for more than five carries as he’s just a week removed from his 100-yard performance against the 49ers for Sunday’s divisional matchup against the Falcons, who allowed the sixth-most fantasy points to opposing running backs in 2015.
Zach Miller's value in Week 4 could come down to who starts under center, as he was a favorite check-down target of Brian Hoyer's last week, but in either case he'll be facing a Lions defense that has allowed a league-high 10 touchdown passes including five to tight ends.
Julian Edelman may struggle if Jacoby Brissett lines up under center Sunday against the Bills, as the game plan will be geared more towards running the football, though Jimmy Garappolo may play despite a shoulder ailment.
Giovani Bernard will take on the Dolphins on Thursday night after catching 16 passes for 141 yards and a touchdown in three games this season.
Vance McDonald (hip) is a solid play if he suits up Sunday against Dallas' 23rd-ranked pass defense.
Cameron Brate caught two touchdowns last week and may be key in unlocking Denver’s tough defense, as they allowed the 11th-most fantasy points to opposing tight ends last season.
Le’Veon Bell will make his season debut Sunday against the Chiefs, a team he rushed for 121 yards against last season in a game that backup quarterback Landry Jones started.
C.J. Anderson had a quiet Week 3 as the Broncos' passing game took the lead, but he should be more involved Sunday against a Buccaneers defense that just gave up two TDs to Todd Gurley.
Jacob Tamme saw his production dip after 11 receptions for 126 yards in the first two weeks, but faces a Panthers' defense that’s allowed 145 yards and two scores to the opponent's featured tight end over the past two weeks.
Travis Kelce scored his first TD of the season in Week 3 but faces a potentially tough matchup Sunday against a Steelers defense that has yet to allow a tight end to find the end zone in 2016.
Gary Barnidge will be up against Washington on Sunday after catching nine passes for 103 yards over his last two contests.
Cairo Santos remains perfect on the season and should have a productive game Sunday against a Steelers defense that ranks in the middle of the pack with 22.0 points allowed per game in 2016.
Dan Carpenter kicked two field goals and three extra points last weekend, though will face a New England defense on Sunday that allows just 15 points per game.