Brady brings a 370.7 yard per game average into a game against a 19th ranked Cowboys pass defense that has allowed 307.5 yards in their last two outings.
Justin Tucker was a perfect 3-for-3 in field goal attempts on Thursday, including the game-winning 52 yarder in overtime, and this week faces a Cleveland Browns defense that ranks near the bottom of the NFL in just about every major defensive category.
Jamaal Charles had his three-game TD streak snapped in last week's loss to the Bengals, but he has a good chance of producing multiple scores Sunday against a woeful Bears defense allowing a league-worst 31.3 points per game.
Forte is averaging 24.3 touches through four games and faces a Chiefs defense that has allowed at least 31 points in three straight games.
Clay has emerged as Tyrod Taylor's favorite target, and the Bills may have to rely on their passing attack if both LeSean McCoy (hamstring) and Karlos Williams (concussion) are out.
Gurley exploded in the second half on the way to 146 yards rushing against the Cardinals in Week 4 and figures to see a heavy workload against a Packers defense that is yielding 115.0 rushing yards per game and 4.8 YPC (third worst in the league) in Week 5.
Matt Ryan should keep rolling along after posting the highest yards per attempt and completion percentage of his season in Sunday's matchup against the Redskins.
Over 600 yards the past two games, and gets an Atlanta pass defense yielding 30 yards per game in what could be a shoot out.
Fitzgerald should have no problem continuing his hot start to the season in a Week 5 matchup against a Lions defense that is yielding 271.5 passing yards per game.
Just 38 yards on five catches, but 12 more targets, and gets to square off a yielding 49ers' defense.
Gould has connected from at least 50 yards three times this season, and his nine made field goals is the second highest total in the league, and will face a Chiefs defense that allows 31.3 points per game, potentially setting him up for a busy afternoon.
Averaging 10 catches on 14 targets through three games, Edelman should be in for another heavy dose of looks against a Cowboys defense that has allowed 307.5 yards per game in their last two outings.
Thanks to the league's highest scoring offense, Gostkowski is averaging 11.7 points through three games and faces a Cowboys defense that has surrendered 26 or more points three times in four outings.
Demaryius Thomas continues to a high target volume and has a favorable matchup in Week 5 against a Raiders defense he hit up for two 100-yard games last year and which is allowing over 300 passing yards a game this season.
Julio Jones may have fallen way off his season-long pace last week (4-38-0), but that doesn't mean he's not still the best receiver in football and should show that Sunday against the Redskins.
Cairo Santos set a club record with seven field goals last week, and gets an opportunity for another big day Sunday against a Bears defense allowing a league-worst 31.3 points per game.
Dixon isn't going to break off many long gains, but he could be in for a heavy Week 5 workload against a questionable defense, as teammates LeSean McCoy (hamstring) and Karlos Williams (concussion) are both in danger of missing the game.
Catanzaro had a huge Week 4 with five field goals and should continue to benefit from a renewed Arizona offense in a Week 5 matchup against the Detroit Lions.
Graham became the first tight end not to score against the Lions in a Week 4 win but he'll look to get back on track against an exploitable Bengals secondary (279.0 passing yards allowed per game) in Week 5.
Lacy is coming off of a season-high 90 yards and faces a Rams defense that is allowing the seventh most rushing yards per game at 120.3.
Manning has thrown multiple touchdown in three straight games, and now gets to feast against a poor 49ers pass defense.
The Cowboys defense has not allowed an opposing tight end to score or catch more than three passes, something that figures to change once Gronkowski and the Patriots leave town in Week 5.
Keenan Allen is on pace for a career season through four games, and as the only healthy Chargers receiver he should see a high target volume Sunday against a vulnerable Steelers secondary.
Leonard Hankerson, now the No. 2 receiver on the high-octane Falcons offense, should have another good week against the Redskins after his first 100-yard receiving day since 2011.
T.J. Yeldon is coming off the first 100-yard game of his career and may get a second in Week 5 against the Tampa Bay Buccaneers, the NFL's 30th-ranked rushing defense.
Matt Bryant will hope for a field goal opportunity after converting all six PAT's last week in Sunday's home matchup with the Redskins.
Palmer and the Arizona passing attack should find plenty of room to operate against a Lions defense who were yielding 271.5 yards passing in the first four weeks of the season.
A healthier Drew Brees gets a good matchup against the Eagles that have allowed 276.5 passing yards per game this season.
Solid play against a bad 49ers' defense and has connected on five 40+ efforts through four weeks.
Matthews has been quiet the past two weeks, but he's easily the safest part of Philadelphia's shaky offense, and he'll face a porous New Orleans secondary in Week 5.
Marques Colston will look to get more than the fifth-most targets on the team in Sunday's matchup against the poor Eagles secondary.
Delanie Walker will be three weeks removed from a wrist injury in Week 5 when the Tennessee Titans host the Buffalo Bills, who have allowed the third most receptions to opposing tight ends.
Coby Fleener is moving ahead of Dwayne Allen as a target as the Indianapolis Colts enter a Week 5 meeting against the Houston Texans.
With 18 targets the past two weeks, Crowder makes for a sneaky play with a good matchup if DeSean Jackson remains sidelined this week.
Ryan Succop has reaped the rewards of the Tennessee Titans' improved offense and looks to build on that in Week 5 against the Buffalo Bills, who allow an average of 23 points per game.
Worthy of consideration now that the bye weeks have started given the comfy matchup against a suspect Atlanta pass defense.
Lynch showed improvement as the week progressed but was ultimately held out of action in Week 4 and will have a stern test against the Bengals (85.8 rushing yards allowed per game) if he's able to return for Week 5.
Boldin might have his best chance at turning around a disappointing start with a Week 5 game matchup against the Giants' league-worst (316.3 yards per game) pass defense.
While he may not catch 80-yard touchdown passes every week, C.J. Spiller gets a good matchup in PPR leagues against an Eagles team that's allowed more than 50 receiving yards to running backs per game.
Foles and the Rams passing attack will face another tough test on the road against the Packers as he looks to build off of last week's three touchdown performance.
Bradford will face a soft defense after last week's impressive second-half rally against the Redskins, but the Philadelphia offense still looks out of sync.
Cobb's volume remains high, averaging 10 targets over the past three games, but faces a sound Rams defense in Week 5 that has allowed only one touchdown to a wide receiver all season.
With so many of his teammates hobbled by injuries, Harvin could see some extra targets against a shaky Tennessee secondary.
Murray should have some holes to run through against a soft New Orleans defense, but the entire Philadelphia offense still looks very shaky.
Owen Daniels has an excellent chance of extending his touchdown streak to three games Sunday against a Raiders defense that's already allowed six tight end TDs in just four games.
Zuerlein could benefit from a renewed ground game behind Todd Gurley in St. Louis but will have a tough road game against the Packers in Week 4.
Johnson turned in a solid performance against the Rams in Week 4 (16 carries, 83 yards) but his value going forward will depend on his ability to keep his starting role with the return of Andre Ellington.
Antonio Gates returns from his suspension Sunday to face a vulnerable Steelers defense that has given up four touchdowns and 7.8 yards per target to tight ends this season.
Could benefit from the injury to tight end Jordan Reed on an offense that has thrown the ball 94 times the past two weeks.
Baldwin gets a favorable draw against a Bengals defense that has allowed the sixth-most passing yards per game (279.0) through the first four weeks of the season in a Week 5.