DeMarco Murray is staying healthy and producing like an elite three-down back entering Week 7's home game against the Indianapolis Colts, who rank 25th in rushing defense and 29th in receiving yards allowed per game to running backs.
Lamar Miller has been a workhorse for the Houston Texans and will be its best weapon for a tough Week 7 matchup against the Denver Broncos, who are the fourth-ranked overall defense, but have dropped to 22nd against the run.
LeGarrette Blount has found the end zone in all but one game this season, and faces a Pittsburgh Steelers' defense on Sunday that allowed a staggering 204 rushing yards and two touchdowns to Miami Dolphins running back Jay Ajayi last weekend.
Matt Jones has topped 115 yards in two of the past three weeks heading into Sunday's matchup with Detroit's 20th-ranked run defense.
If Doug Martin (hamstring) can play on Sunday against the 49ers, he’s up for a big game after they allowed more than 300 rushing yards to the Bills last week.
Rashad Jennings has a friendly matchup against the 22nd-ranked Rams run defense Sunday in London, but New York's reluctance to run the ball significantly limits his upside.
Le’Veon Bell will face the Patriots on Sunday, as he’ll try to become the fourth opposing running back to post at least 94 yards in 2016.
LeSean McCoy broke out against the worst rushing defense in the NFL, and would have another favorable matchup this weekend against a Miami Dolphins defense allowing 147 rushing yards per game, but hurt his hamstring in practice and may not suit up.
Christine Michael should get plenty of carries Sunday as the Seahawks attack Arizona's 17th-ranked run defense rather than their 3rd-ranked secondary.
Dwayne Washington would have an inviting opportunity against a Redskins defense that allows 5.0 yards per carry and 124 yards per game should he be able to return to action from an ankle injury that has kept him out of the last two games.
Eddie Lacy remains clearly limited by an ankle injury and faces a short recovery week with a Thursday matchup against a Bears defense allowing 3.9 yards per carry looming.
Chris Ivory out-touched starter T.J. Yeldon for the first time this season last week and looks to build off that in Week 7 against the Oakland Raiders, who rank 30th in rushing defense.
Jacquizz Rodgers may not see 35 touches again if Doug Martin’s healthy, but should be able to go for more than 3.4 yards per carry this week against the 49ers, who allowed the Bills to run for more than 300 yards in Week 6.
C.J. Anderson was held in check once again in Week 6, but now heads home to face a Texans defense allowing 126.3 rushing yards a game, 29th in the league.
Carlos Hyde's workload, assuming he plays through a shoulder injury, makes him a solid option Sunday against Tampa Bay despite the underwhelming nature of San Francisco's offense.
Devonta Freeman will look to bounce-back after just 40 rushing yards against the Seahawks in this week’s matchup with the Chargers, who’ve allowed six backs to catch four or more passes.
James White hauled in two touchdown passes last weekend and faces a Pittsburgh defense on Sunday that's allowing 294 passing yards per game in 2016.
Isaiah Crowell will be up against the Bengals in Week 7 that have given up five touchdowns to the running backs they’ve faced in the past two weeks.
Spencer Ware had a big Week 6 despite an increased workload for Jamaal Charles and, even in a timeshare, Ware should be productive Sunday against a Saints defense that's given up a league-worst 11 rushing TDs.
Zach Zenner could be a surprise in Week 7 against a Redskins defense that is allowing 124 yards per game on the ground, assuming Dwayne Washington and Theo Riddick remain sidelined, allowing Zenner to function as the Lions early-down back.
Jay Ajayi exploded for 204 yards and two touchdowns last weekend despite the return of Arian Foster from injury, and faces a surprisingly mediocre Buffalo rushing defense this Sunday that's allowing 103.2 yards per game on the ground in 2016.
Todd Gurley is averaging only 2.9 yards per carry heading into Sunday's London game against the 12th-ranked Giants run defense.
T.J. Yeldon, who had fewer touches than Chris Ivory last week, looks to reclaim his spot atop the running back depth chart in Week 7 against the Oakland Raiders, who rank 30th in rushing defense.
Tevin Coleman’s value will come as a pass-catcher this week against a Chargers defense that’s allowed six running backs to catch four or more passes while allowing more 100-yard receivers out of the backfield than rushers.
Frank Gore is producing better in 2016 than he did last season and has even shown how he is a capable receiver entering Week 7 against the Tennessee Titans, who rank seventh in rushing defense and 20th in receiving yards allowed per game to backs.
David Johnson has 268 rushing yards and five touchdowns over the past three weeks, and will attempt to prove that he's matchup-proof Sunday against a Seahawks defense that ranks in the top five against both the run and the pass.
Jamaal Charles scored his first touchdown of the season in Week 6 despite only getting 11 touches, and even splitting snaps with Spencer Ware he should be productive Sunday against a Saints defense that's given up a league-worst 11 rushing TDs.
Mike Gillislee has scored in back-to-back games, and if LeSean McCoy can't play due to a hamstring injury, would be an extremely sneaky pickup against the suspect Miami Dolphins rushing defense.
Mark Ingram’s struggles could continue on Sunday against the Chiefs, who’ve allowed just three rushing touchdowns this season, but have allowed three different backs to go for five or more receptions.
Devontae Booker received praise from head coach Gary Kubiak after Week 6 and could see an expanded role going forward, starting with Monday's home game against a Texans defense that's allowing 126.3 rushing yards per game, 29th in the league.
Melvin Gordon fell just shy of his second 100-yard game last week, but gets a tough matchup Sunday against a Falcons defense that has yet to allow a run longer than 26 yards this season.
Jordan Howard is coming off his worst game as a starter and now faces a second-ranked Packers rush defense that had not allowed more than 39 yards to an opposing running back prior to last week's shredding by the Cowboys' Ezekiel Elliott.
Jerick McKinnon will continue splitting carries with Matt Asiata in Week 7 against an Eagles defense that just allowed their first 100-yard rusher of the season last week, but had previously not allowed more than 62 yards to any one back.
Darren Sproles has a tough matchup Sunday against a Vikings defense that's allowing just 287.6 yards from scrimmage per game.
Matt Asiata remains the favorite for goal line carries but has been out-touched by Jerick McKinnon in three straight games, and now faces an Eagles defense that has allowed only three rushing touchdowns through five games.
Terrance West will have a Sunday tilt against the Jets as he attempts to become the first running back to post 75 yards against this defense.
Justin Forsett's role against a 28th-ranked Redskins rush defense is uncertain given the unknown health of Dwayne Washington and Theo Riddick.
Bobby Rainey has some value as a pass-catcher, but Rashad Jennings will be the primary running back in Week 7 against the Rams.
Giovani Bernard will face the Browns on Sunday when he’ll try to post at least 94 total yards for the third consecutive game.
Jeremy Hill will have a Sunday matchup against a Browns defense that ranks 27th by allowing 118 yards per game, but curiously has allowed only two running backs to gain more than 76 yards against them.
Duke Johnson will have a Sunday matchup against the Bengals as he comes off a stretch in which he’s posted at least 56 yards from scrimmage in four of his last five games.
Arian Foster returned from injury last weekend and notched five touches, but could remain the backup on Sunday against the Buffalo Bills after Jay Ajayi exploded for 204 yards on the ground.
DeAngelo Williams will be up against the Patriots on Sunday after failing to surpass 10 yards in any of the last three games since Le'Veon Bell returned from suspension.
Powell had six touches for just 22 yards last game, and faces a Ravens defense in Week 7 that's allowing the third-fewest yards per game in the NFL.
Matt Forte is coming off his worst game of the season, and has been held out of the end zone for four-straight contests, and faces a Baltimore defense in Week 7 that's allowed the fewest rushing yards per game in the NFL thus far.
Derrick Henry had his fewest rushing attempts of the season in Week 6 and does not appear to be a threat to DeMarco Murray in the Tennessee Titans' plan of attack as they enter a Week 7 home game against the Indianapolis Colts.
Latavius Murray is still working his way back from a turf toe injury, but if he is able to play Sunday he'll be facing a Jaguars defense allowing only 3.8 yards per carry, 12th in the league.
Theo Riddick's availability for Week 7 against the Washington Redskins is uncertain after he missed last week's contest due to an ankle injury.
Kenneth Dixon will have a Week 7 matchup against the Jets though he’s had just seven touches in his first two games of the 2016 season.
DeAndre Washington has seen a slight increase in his touches while Latavius Murray has been sidelined, but Murray's potential return Sunday will limit his ceiling against a Jaguars defense allowing only 3.8 yards per carry, 12th in the league.