DeSean Jackson's big play ability makes him a strong play Sunday against a 25th-ranked Browns pass defense that has given up more than its fair share of long gains.
Ezekiel Elliott rushed for 140 yards on 30 carries last week, and will get the ball early and often again facing the 49ers' 23rd-ranked run defense Sunday.
Melvin Gordon scored his fourth TD of the season in Week 3 and gets a premium matchup Sunday at home against a Saints defense allowing a league-worst 149.3 rushing yards per game so far.
Kirk Cousins is primed for another huge performance against a Browns team that's allowing 294.3 passing yards per contest considering that he has surpassed that mark in every game this season.
Greg Olsen had an “off” week last week (six receptions, 64 yards), but faces a Falcons defense that’s allowed four touchdowns to opposing tight ends this season.
Jordan Howard has an inviting matchup against a Lions defense which is allowing a league-high 5.1 yards per carry, and would see a boost in appeal should Jeremy Langford (ankle) miss the contest.
Josh Lambo connected on three field goals in Week 3 and gets a very favorable matchup Sunday at home against a Saints defense that's allowed 32.0 points per game so far, second-worst in the league.
DeAndre Hopkins and the rest of the Houston offense had a tough Week 3 and will look to get back in the win column against a disappointing Tennessee Titans, who have allowed 186 yards per game to wide receivers.
Jeremy Hill has a Thursday matchup against a Dolphins’ defense that allowed 123 rushing yards to LaGarrette Blount in Week 2 and then 148 yards to the Browns’ duo of Isaiah Crowell and Duke Johnson last week.
Justin Tucker will take on the Raiders in Week 4 after making all nine of his field goal attempts over the first three weeks of the season.
Matthew Stafford has topped 330 yards while throwing for three touchdowns in two games this season, and faces a Bears defense that is surrendering 27.7 points per game.
Andrew Luck's overall play remains spotty to start the 2016 season, but he remains dangerous entering Week 4 as the Colts face the winless Jacksonville Jaguars, whose coach may be the first to be fired in 2016.
Pierre Garcon has been outplayed by both DeSean Jackson and Jamison Crowder among Redskins wide receivers, but could still put up big numbers Sunday against Cleveland's 25th-ranked pass defense.
Joe Flacco will be at home to take on a Raiders’ defense that he had 384 passing yards and two touchdowns against when facing them in 2015.
Todd Gurley should be able to follow last week's two-touchdown performance with another strong game Sunday against a Cardinals defense that ranks 29th against the run.
Stephen Gostkowski continues to shine regardless of who lines up under center for the Pats, and will face a Buffalo Bills defense allowing a mediocre 22.7 points per tilt.
Terrelle Pryor will face Washington on Sunday, and it’s possible that he’ll continue to see snaps as a Wildcat quarterback, which could give him major upside this week.
Dak Prescott has scored on the ground in back-to-back games, which makes him a solid Week 4 option against a 49ers team that has struggled to contain dual-threat quarterbacks.
Jordan Reed has been relatively quiet thus far, but could break out Sunday against a Browns team that ranks 25th in defending the pass.
John Brown will look to follow last week's 70-yard performance with another strong effort Sunday against a Rams team that gave up 94 yards per game to him last season.
Cole Beasley doesn't make many big plays, but rookie quarterback Dark Prescott should continue to look for him early and often Sunday against the 49ers after completing 20 passes for 213 yards to him through three weeks.
Kyle Rudolph has seen eight targets or more in all three games, catching two touchdowns, but faces a Giants defense on Monday night that has yet to allow a tight end to reach the end zone.
A.J. Green has a Thursday matchup against a Dolphins’ defense that coughed up eight receptions for 144 yards to Terrelle Pryor last week.
DeMarco Murray, more than anyone else on the Titans' roster, is a sure play in Week 4 against the Houston Texans, who rank 27th in rushing defense.
Brandin Cooks was targeted eight times, but pulled in just two receptions for 13 yards against the Falcons and will look to find his form against the Chargers, who allowed eight receptions for 174 yards to T.Y. Hilton last week.
Marvin Jones is averaging 22.7 yards per catch and has popped for at least one catch of 30+ yards weekly heading into a matchup against a Bears defense that is allowing only 214 yards per game through the air.
After his first no-catch game of his career, Kelvin Benjamin should get back on track in what promises to be a shootout against the Falcons, who have allowed 10 touchdown passes this season.
Cam Newton will look to shake off his first game with three interceptions since Week 7 last year against the Falcons, who’ve allowed seven passing touchdowns against one interceptions through their first two games.
Travis Benjamin has averaged 19.7 yards per catch over the last two games and should be explosive once again Sunday at home against a Saints defense allowing nearly 300 passing yards a game so far.
T.Y. Hiltons' breakout in Week 3 was a welcome sign and points to similar production in Week 4 against the Jacksonville Jaguars, who have been stout against the pass but have allowed 35 catches for 714 yards to Hilton in eight career games.
Dennis Pitta will face a Raiders’ defense on Sunday that has allowed at least 59 receiving yards to three different tight ends this season.
Jamison Crowder already has 16 catches for 175 yards and two touchdowns this season, and likely won't slow down Sunday against a Browns team allowing 294.3 passing yards per game.
Antonio Brown will face the Chiefs on Sunday night after torching this defense for 124 last year in a game that backup quarterback Landry Jones started.
Dan Bailey missed one against Chicago, but should be able to rebound Sunday against a 49ers team that has been unimpressive since a Week 1 shutout.
Lamar Miller has been Houston's workhorse through the first three games, ranking second among running backs with 74 carries, and will carry the load once again in Week 4 against the Tennessee Titans, who rank 17th in rushing defense.
LeGarrette Blount will once again be the focal point of the New England offense without Tom Brady, though he will face a Buffalo Bills defense allowing just 98 yards per game on the ground.
Isaiah Crowell has a Sunday contest against a Washington defense that has allowed six touchdowns to running backs through three games this season.
Ryan Tannehill tossed three touchdown passes last weekend and faces a Cincinnati Bengals defense that has already given up nine passing touchdowns in 2016, which is 31st in the NFL.
Carson Palmer will look to bounce back from last week's four-interception performance Sunday against a Rams team that he carved up for over 350 yards in both 2015 meetings.
Drew Brees threw his first pick in more than 300 pass attempts on Monday night, but faces a Chargers defense that’s allowed 329 or more passing yards in each of the first three weeks.
Allen Robinson asserted himself in the offense in Week 3 (two TDs) and looks to continue that in Week 4 against the Indianapolis Colts, who rank 30th in scoring defense.
Garrett Celek could monopolize the receiving production at the tight end position Sunday against the Cowboys if Vance McDonald (hip) is unable to suit up.
Jason Witten is mostly settling for a blocking role in a run-first Dallas offense, but Seahawks tight end Jimmy Graham's big game against these 49ers last week gives the veteran hope for a vintage receiving performance Sunday.
Allen Hurns is finding it hard to repeat last season's success, but some of that can be traced to the poor start of quarterback Blake Bortles. Week 4 brings some hope as Jacksonville faces the Indianapolis Colts and their 26th-ranked receiving defense.
Vance McDonald (hip) is a solid play if he suits up Sunday against Dallas' 23rd-ranked pass defense.
C.J. Anderson had a quiet Week 3 as the Broncos' passing game took the lead, but he should be more involved Sunday against a Buccaneers defense that just gave up two TDs to Todd Gurley.
Jacob Tamme saw his production dip after 11 receptions for 126 yards in the first two weeks, but sees a Panthers defense that’s allowed 145 yards and two scores to the featured tight end over the past two weeks.
Gary Barnidge will be up against Washington on Sunday after catching nine passes for 103 yards over his last two contests.
Jack Doyle has been unable to repeat his season-opening, two-TD performance in Week 1, but is tied for second on the team in targets and is second in receptions entering a Week 4 matchup against the Jacksonville Jaguars.
Emmanuel Sanders is coming off a huge Week 3 and could be productive once again Sunday against a Buccaneers secondary that has already allowed seven passing TDs through three games.