Ezekiel Elliott rushed for 140 yards on 30 carries last week, and will get the ball early and often again facing the 49ers' 23rd-ranked run defense Sunday.
Kirk Cousins is primed for another huge performance against a Browns team that's allowing 294.3 passing yards per contest considering that he has surpassed that mark in every game this season.
DeSean Jackson's big play ability makes him a strong play Sunday against a 25th-ranked Browns pass defense that has given up more than its fair share of long gains.
Greg Olsen had an “off” week last week (six receptions, 64 yards), but he has a Week 4 matchup against a Falcons defense that’s allowed four touchdowns to opposing tight ends this season.
Melvin Gordon scored his fourth TD of the season in Week 3 and gets a premium matchup Sunday at home against a Saints defense allowing a league-worst 149.3 rushing yards per game so far.
Joe Flacco will be at home to take on a Raiders’ defense that he had 384 passing yards and two touchdowns against when facing them in 2015.
Kyle Rudolph has seen eight targets or more in all three games, catching two touchdowns, but faces a Giants defense on Monday night that has yet to allow a tight end to reach the end zone.
Lamar Miller has been Houston's workhorse through the first three games, ranking second among running backs with 74 carries, and will carry the load once again in Week 4 against the Tennessee Titans, who rank 17th in rushing defense.
T.Y. Hiltons' breakout in Week 3 was a welcome sign and points to similar production in Week 4 against the Jacksonville Jaguars, who have been stout against the pass but have allowed 35 catches for 714 yards to Hilton in eight career games.
Todd Gurley should be able to follow last week's two-touchdown performance with another strong game Sunday against a Cardinals defense that ranks 29th against the run.
Jordan Howard has an inviting matchup against a Lions defense which is allowing a league-high 5.1 yards per carry, and would see a boost in appeal should Jeremy Langford (ankle) miss the contest.
Marvin Jones is averaging 22.7 yards per catch and has popped for at least one catch of 30+ yards weekly heading into a matchup against a Bears defense that is allowing only 214 yards per game through the air.
Justin Tucker will take on the Raiders in Week 4 after making all nine of his field goal attempts over the first three weeks of the season.
DeMarco Murray, more than anyone else on the Titans' roster, is a sure play in Week 4 against the Houston Texans, who rank 27th in rushing defense.
Dak Prescott has scored on the ground in back-to-back games, which makes him a solid Week 4 option against a 49ers team that has struggled to contain dual-threat quarterbacks.
DeAndre Hopkins and the rest of the Houston offense had a tough Week 3 and will look to get back in the win column against a disappointing Tennessee Titans, who have allowed 186 yards per game to wide receivers.
Terrelle Pryor will face Washington on Sunday, and it’s possible that he’ll continue to see snaps as a Wildcat quarterback, which could give him major upside this week.
Jordan Reed has been relatively quiet thus far, but could break out Sunday against a Browns team that ranks 25th in defending the pass.
John Brown will look to follow last week's 70-yard performance with another strong effort Sunday against a Rams team that gave up 94 yards per game to him last season.
Dan Bailey missed one against Chicago, but should be able to rebound Sunday against a 49ers team that has been unimpressive since a Week 1 shutout.
Jeremy Hill has a Thursday matchup against a Dolphins’ defense that allowed 123 rushing yards to LaGarrette Blount in Week 2 and then 148 yards to the Browns’ duo of Isaiah Crowell and Duke Johnson last week.
Allen Robinson asserted himself in the offense in Week 3 (two TDs) and looks to continue that in Week 4 against the Indianapolis Colts, who rank 30th in scoring defense.
Andrew Luck's overall play remains spotty to start the 2016 season, but he remains dangerous entering Week 4 as the Colts face the winless Jacksonville Jaguars, whose coach may be the first to be fired in 2016.
Josh Lambo connected on three field goals in Week 3 and gets a very favorable matchup Sunday at home against a Saints defense that's allowed 32.0 points per game so far, second-worst in the league.
Jamison Crowder already has 16 catches for 175 yards and two touchdowns this season, and likely won't slow down Sunday against a Browns team allowing 294.3 passing yards per game.
Antonio Brown will face the Chiefs on Sunday night after torching this defense for 124 last year in a game that backup quarterback Landry Jones started.
Pierre Garcon has been outplayed by both DeSean Jackson and Jamison Crowder among Redskins wide receivers, but could still put up big numbers Sunday against Cleveland's 25th-ranked pass defense.
Matthew Stafford has topped 330 yards while throwing for three touchdowns in two games this season, and faces a Bears defense that is surrendering 27.7 points per game.
Dennis Pitta will face a Raiders’ defense on Sunday that has allowed at least 59 receiving yards to three different tight ends this season.
Isaiah Crowell has a Sunday contest against a Washington defense that has allowed six touchdowns to running backs through three games this season.
Travis Benjamin has averaged 19.7 yards per catch over the last two games and should be explosive once again Sunday at home against a Saints defense allowing nearly 300 passing yards a game so far.
Carson Palmer will look to bounce back from last week's four-interception performance Sunday against a Rams team that he carved up for over 350 yards in both 2015 meetings.
Drew Brees threw his first pick in more than 300 pass attempts on Monday night, but he'll look to get back on track in Week 4 against a Chargers defense that’s allowed 329 or more passing yards in each of the first three weeks.
Cole Beasley doesn't make many big plays, but rookie quarterback Dark Prescott should continue to look for him early and often Sunday against the 49ers after completing 20 passes for 213 yards to him through three weeks.
A.J. Green has a Thursday matchup against a Dolphins’ defense that coughed up eight receptions for 144 yards to Terrelle Pryor last week.
Allen Hurns is finding it hard to repeat last season's success, but some of that can be traced to the poor start of quarterback Blake Bortles. Week 4 brings some hope as Jacksonville faces the Indianapolis Colts and their 26th-ranked receiving defense.
Dwayne Washington is the best bet in a limited rushing offense, and faces a Bears defense that ranks second-to-last against the run, allowing 142.7 yards per game
Jimmy Graham has the skills to burn the Jets on Sunday, but question marks at quarterback for Seattle put a major dent in his value.
Phillip Dorsett has just 57 receiving yards the last two weeks and hasn't yet scored a touchdown this season, but remains on the radar for Week 4 against the Jacksonville Jaguars because the Colts' No. 2 receiver Donte Moncrief (shoulder) will miss the next 4-to-6 games.
Can Will Fuller and the Texans make the necessary adjustments this week after the rookie was held to 31 yards in Week 3? They face a familiar team in the Tennessee Titans, who rank 11th in receiving defense.
Travis Kelce scored his first TD of the season in Week 3 but faces a potentially tough matchup Sunday against a Steelers defense that has yet to allow a tight end to find the end zone in 2016.
Coby Fleener will look to build off Monday night’s 100-yard performance in Week 4 against the Chargers, who’ve allowed a tight end to break the 65-yard barrier in each of the first three weeks.
Stefon Diggs remains the Vikings best chance at a big play, and should find room to operate Monday night against a Giants defense that is surrendering 262 yards per game
Jeremy Maclin is coming off his worst game of the season in Week 3, but should be more productive Sunday against a Steelers defense that ranks 31st in passing yards allowed so far.
Delanie Walker, who missed Week 3 with a hamstring injury, is scheduled to practice Thursday and appears to be working toward being available in Week 4 against the Houston Texans.
As the Titans' leading target, Tajae Sharpe deserves a look any week, but Week 4 should make owners ponder using him as a starter as the Titans face the Houston Texans, who rank first receiving defense.
Alfred Morris has vultured a couple touchdowns, but Ezekiel Elliott is still the clear go-to running back in Dallas heading into Sunday's plus matchup with the 49ers.
Ryan Tannehill tossed three touchdown passes last weekend and faces a Cincinnati Bengals defense that has already given up nine passing touchdowns in 2016, which is 31st in the NFL.
Wil Lutz knocked through a 57-yarder against the Falcons, looking more comfortable with each successive week and will try to continue that trend Sunday against the Chargers.
Cameron Artis-Payne averaged 3.9 yards per carry against the Vikings and should find more room to run Sunday against the Falcons, who allowed the sixth-most fantasy points per game to opposing running backs last season.