Rob Gronkowski faces an Indianapolis Colts defense that has allowed eight passing touchdowns in 2015, tied for 19th in the NFL.
Palmer shouldn't have much trouble building on his early-season success in a matchup with the shaky Pittsburgh secondary.
Fitzgerald has cooled off a bit, but he's still the top receiving option in an excellent offense, and he'll face a soft Pittsburgh secondary in Week 6.
Julian Edelman faces an Indianapolis Colts defense that is allowing 287 passing yards per game, which is 28th in the NFL.
Tom Brady, sure to be motivated by last year's Deflategate saga, faces an Indianapolis Colts defense that is 28th in the NFL in terms of passing yards allowed this season.
Stephen Gostkowski has hit at least three field goals in three-straight games and faces the 16th ranked scoring defense of the Indianapolis Colts.
Catanzaro should eventually see some of his extra points turn to field goals, and the Cardinals shouldn't have too much trouble moving the ball against the Steelers.
Dion Lewis has become a vital part of the New England passing attack and clashes with an Indianapolis Colts defense ranked 28th in the league in defending the pass.
Peterson is averaging 5.0 yards per carry but faces a Chiefs defense that is giving up only 3.9 per tote, making him just one of the top options in Week 6 instead of the top choice.
13 field goals through five weeks lead the league.
Carves up Saints' defense for 333 yards and now faces a Giants' defense allowing a league-worst 304.2 passing yards per game.
Brandon Marshall has three-straight 100-yard games to his credit, though will face a Washington Redskins defense allowing just 216.4 yards per game through the air.
Rodgers seems likely to bounce back from a three-turnover performance against a Chargers defense that allowed Browns' quarterback Josh McCown to throw for 356 yards and two scores two weeks ago.
Le'Veon Bell is the unquestioned workhorse for the Pittsburgh Steelers, guaranteed to be among the NFL leaders in touches on a game-to-game basis, including this week against a strong Arizona Cardinals squad that has only given up two rushing touchdowns this season.
Lacy could break out against a Chargers defense that is allowing 130.2 yards per game on the ground through five weeks.
Emmanuel Sanders is coming off his first 100-yard game of the season, and could thrive Sunday against a beat-up Browns secondary allowing 7.9 yards per pass attempt.
Boldin may be stuck in a highly questionable offense, but he's the clear top receiving option and gets to face a weak Baltimore pass defense.
Larry Fitzgerald is still the go-to guy, but there should be enough to go around for both him and Brown against a soft Pittsburgh secondary.
Bennett's volume remains high, having 24 targets in the past two weeks, something that is unlikely to decrease unless Alshon Jeffery and Eddie Royal are both active for Week 6 at Detroit.
Brandon McManus remains perfect on the season and gets another opportunity for a productive game Sunday against a Browns defense allowing 26.7 points per game.
T.J. Yeldon suffered a groin injury last week and is sure to be in the injury report all week leading up to the Jacksonville Jaguars' Week home game against the Houston Texans, who rank 23rd in rushing yards allowed per game.
Marcus Mariota and the Tennessee Titans have a Week 6 match-up against the Miami Dolphins, who have allowed 25 points per game.
Melvin Gordon is still looking for his first touchdown and first 100-yard game in the NFL, but gets a great opportunity for both Sunday against a Packers defense allowing 5.0 yards per carry, third-worst mark in the league.
Dallas may be chasing touchdowns against the Patriots, limiting Bailey's opportunities.
Tyrod Taylor continues his surprise campaign against a Cincinnati Bengals defense allowing 263 passing yards per game, which is 22nd in the NFL.
Julius Thomas was a surprise activation last week and played about half of the Jacksonville Jaguars' snaps. He'll increase his role in Week 6 against the Houston Texans.
Demaryius Thomas continues to see a high volume of targets with a career-low YPT, reducing his overall production, but Sunday's game against a Browns secondary allowing 7.9 yards per pass attempt could allow him to see more action downfield.
Josh Lambo has had an inconsistent rookie season so far, but despite facing a Packers defense Sunday allowing just 16.2 points per game he could get plenty of scoring chances as Philip Rivers attempts to keep pace with Aaron Rodgers.
Delanie Walker averages over six targets per game, tops among tight ends, entering Week 6 when the Tennessee Titans face the Miami Dolphins.
Seven targets and the game-winning score, though he was held to under 40 yards for the fifth straight game.
Cobb remains a threat to go off at any moment as Aaron Rodgers favorite target, but against a Chargers defense that is struggling against the run, expectations for Cobb this week can be kept in check.
Antonio Brown is one of the best receivers in the NFL when Ben Roethlisberger is playing quarterback but has yet to establish a rhythm with Michael Vick, and will be challenged to do so this week against a strong Arizona Cardinals defense that leads the NFL in interceptions.
Kendall Wright is the Tennessee Titans' leading target as they prepare for a Week 6 match-up against the Miami Dolphins, who rank 20th in points allowed per game.
The Bears are allowing just 189 yards per game through the air, but Johnson has scored five times and averaged 94 yards in his last four meetings with Chicago.
Chris Ivory is healthy and coming off a monster game, but faces a stiff test against a Washington Redskin defense that has allowed just two rushing touchdowns in 2015.
Cutler has topped 250 yards and thrown for two touchdowns in each game since returning from a hamstring injury, and faces a Lions defense that has only three interceptions on the year.
Eight catches against the 49ers after curiously targeted just three times total in the prior two weeks makes him relevant again in PPR formats.
Gould will have the added benefit of kicking indoors Sunday at the Detroit Lions, who are allowing 27.6 points per game, the seventh highest total through five weeks.
Kaepernick bounced back from a nasty slump in Week 5, and he now gets to face a porous Baltimore pass defense. Given his early-season struggles, it's still far from a sure thing.
Lamar Miller faces a Tennessee Titan defense allowing 117 yards per game on the ground, which is 23rd in the NFL.
Johnson is the clear lead back in an excellent offense, but a Week 6 matchup with the Steelers could dictate a pass-heavy approach.
Eris Decker has scored a touchdown in every game he's played this season, though faces a surprisingly tough Washington Redskins defense allowing just 20.8 points per game.
Ryan Succop has not missed a kick through four games and looks to pad the stats in Week 6 against the Miami Dolphins, who rank 20th points allowed per game.
Jones continues to catch long balls and touchdowns, and will be a boom-or-bust option against a Chargers defense that has allowed eight touchdowns and 219 yards per game through the air.
Allen Hurns has shaken off the drops from a year ago and is a reliable second wide out as the Jacksonville Jaguars prepare for the Houston Texans in Week 6.
Could benefit as the primary pass-catching option out of the backfield with Lance Dunbar sidelined for the season.
Antonio Gates didn't miss a beat in his return from a four-game suspension, catching two touchdowns passes in Week 5, and despite facing a Packers defense Sunday that's been tough on tight ends he could have another big game if the Chargers fall into an early hole and have to play catch-up.
Blake Bortles is dealing with a sprained AC joint in his throwing shoulder, but is expected to play Week 6 against the Houston Texans, who have given up over 736 yards passing the last two games.
Jeremy Maclin was already on pace for a career year and could see a larger role in the offense with Jamaal Charles out for the season, but he has a tough matchup Sunday against a Vikings defense allowing just 6.7 yards per pass attempt, the 7th-best mark in the league.
Hyde will face a Baltimore defense that begs for a pass-heavy approach, but he could see some extra targets if Reggie Bush (calf) doesn't play.