Aaron Rodgers faces a 49ers defense that has allowed an average of 340 yards through the air in the last two weeks.
A.J. Green had a huge game in Week 4 against the Baltimore Ravens, and has the chance to continue his hot play against a struggling Kansas City Chiefs pass defense that is 28th in the NFL in yards allowed (287 ypg) and dead last in touchdowns allowed (10 overall).
Antonio Brown had a routinely big game in Week 3 against a strong St. Louis Rams defense, and despite his lack of reps with new quarterback Michael Vick, Brown should still be expected to produce next week against a Baltimore Ravens defense that has given up more than 350 yards passing in each of their last two games.
James Jones has a touchdown in all three games to date, and faces a 49ers defense which has allowed five touchdowns through the air in their last two outings.
Mason Crosby ranks fourth among kickers with 28 points through three games, and should see ample chances in a game where the Packers could score early and often.
Julio Jones has been the best receiver in the league this year and Kevin Johnson will have a world of trouble trying to stop him for the Texans on Sunday.
Le'Veon Bell has returned as the centerpiece of the Pittsburgh Steelers offense at a time when starting quarterback Ben Roethlisberger is injured, which likely makes him an even bigger part of the offense against a stout Baltimore Ravens run defense this week.
Tyler Eifert was held without a catch in Week 3 after tremendous success in the first two weeks, but gets the chance to bounce back in Week 4 against a Kansas City Chiefs defense that currently ranks 28th in the NFL in passing yards allowed and last in passing touchdowns allowed.
Greg Olsen will look to build off a mammoth week (8-134-2) in Sunday's divisional matchup against the Bucs.
Derek Carr gets another opportunity for a big performance Sunday against a reeling Bears defense that's allowed a league-worst 35 points a game.
Allen Robinson has become a big-play target for the Jacksonville Jaguars entering Week against the Indianapolis Colts, who have the NFL's 20th-ranked defense.
Odell Beckham gets a matchup against a Buffalo Bills pass defense that has yielded lots of yards through the first three weeks.
Brandon Marshall has found the end zone in every game this season, the New York Jets are banged up at wide receiver, and they clash with a bumbling Miami Dolphins defense allowing 246 passing yards per contest.
Russell Wilson welcomes a 26th-ranked Lions defense to CenturyLink Field on Monday that allowed Peyton Manning and Philip Rivers to thrown for a combined 727 yards.
Andy Dalton had a monster game in Week 3 against the Baltimore Ravens, and will be looking for his third straight game over 350 yards passing against a struggling Kansas City Chiefs defense that was just burned by Aaron Rodgers for five passing touchdowns in Week 3.
Chandler Catanzaro only has two field goal attempts through three games, but he's attached to a scorching-hot offense and should thus get plenty of chances by the end of the season.
Emmanuel Sanders could be in line for a big game Sunday against a Vikings defense that has shut down deeper routes so far this season, as Peyton Manning continues to compensate for an ineffective Broncos running game.
Tyrod Taylor clashes with the New York Giants, who have allowed a staggering 335 passing yards per game, which is last in the NFL.
Latavius Murray busted out last week and has a great opportunity for a repeat performance Sunday against a Bears defense allowing 4.7 yards a carry and a league-worst 35 points a game.
Jimmy Graham has scored in two of three contests, and faces a Lions defense that has allowed opposing tight ends to score in every week to date.
Justin Tucker is one of the most accurate kickers in the NFL, despite his miss from 50 yards in Week 3, but faces a match-up against a Pittsburgh Steelers defense that doesn't give up many points (sixth fewest in the NFL) which could actually be a boon for a kicker, if the opposing defense is able to keep them out of the end zone and force field goal attempts.
Amari Cooper seems poised for another big performance in Week 4 against a reeling Bears defense that's allowed a league-worst 35 points a game.
Melvin Gordon has the best matchup of his young career Sunday, at home against a Browns defense allowing 4.9 yards per carry.
Eddie Lacy emerged from Week 3 without any further damage to his ankle, and faces a 49ers defense that has allowed five rushing touchdowns in their last two contests.
Martellus Bennett has an inviting matchup against a Raiders defense that has allowed five touchdowns and 297 yards to opposing tight ends through three games, though it is not a guarantee quarterback Jimmy Clausen will be allowed to throw enough for Bennett to match that kind of production.
Steven Hauschka ranks third among kickers in scoring with 30 points through three weeks and faces a Lions defense that has surrendered at least 24 points in every outing this season.
Jordan Reed had six more catches last week, and could have had a bigger day if not for a pair of under-throws from QB Kirk Cousins.
Matt Ryan will look to build off his strong start (315 passing yards per game) against the Texans secondary on Sunday.
Joe Flacco has used a rekindled connection with Steve Smith to produce consecutive 350+ yard games, and this week he faces a Pittsburgh Steelers defense that is in the bottom third in the NFL in both passing yards and passing touchdowns allowed.
Steve Smith has detonated for 23 receptions and 336 yards over the last two weeks, and this week faces a vulnerable Pittsburgh Steerls defense that is in the bottom third in the NFL in both passing yards and touchdowns allowed.
Eli Manning threw two more scores last week and now squares off in Week 4 against a Buffalo pass defense allowing 326.7 YPG.
Matt Bryant gets another opportunity to kick indoors as the Falcons take on the Texans at home on Sunday.
Randall Cobb faces a 49ers secondary that has allowed an average of nine catches and 164.5 yards and three total touchdowns to opposing team's top receivers in their last two games.
Larry Fitzgerald has been a dominant force in the red-hot Arizona offense through three weeks, but a pillow-soft early-season schedule helped, and the Rams figure to offer more of a challenge.
T.J. Yeldon has solidified his hold as the Jacksonville Jaguars' running back, heading into a Week 4 encounter against the Indianapolis Colts, who rank 21st in rushing yards allowed per game.
Thomas Rawls proved his ability last Sunday and, if Marshawn Lunch is unable to play through a hamstring injury, could shine Monday night against a 20th-ranked Lions rush defense that has allowed five touchdowns this season.
Dan Carpenter squares off against the New York Giants on Sunday; the G-Men are allowing a pedestrian 24 points per game in 2015.
Brandon McManus remains a solid play Sunday thanks to Peyton Manning's turnaround, despite facing a Vikings defense allowing just 16.7 points per game.
Adrian Peterson leads the league in rushing through three weeks, but faces a stout test in the Broncos sixth-ranked rush defense that has held two of its three opponents to less than 3.5 yards per carry.
Jonathan Stewart will look to get on track in Sunday’s matchup against the Bucs after averaging fewer than 57 rushing yards per game in the first three weeks.
Ted Ginn Jr. will look to build off his highest receiving yard total since he was a Dolphin, in Week 2 of the 2009 season, during Sunday’s matchup with the Bucs.
Blake Bortles looks to rebound in Week 4 against the Indianapolis Colts, who rank 21st in passing yards allowed per game.
Matt Forte should again be the focal point of the injury-laden Bears offense against an Oakland Raiders defense that allowed 118.0 yards on the ground in the first two weeks of the year before limiting Browns to 39 yards last Sunday.
Brandin Cooks will look to find room underneath against the swarming Cowboys secondary that held Odell Beckham Jr. to just 44 yards in Week 1.
Peyton Manning has put his ugly Week 1 performance behind him and should continue to deliver a higher volume of passes than expected under Gary Kubiak as long as the Broncos running game remains ineffective.
Joseph Randle scored three touchdowns early but shut down in the second half of Week 3 as Atlanta adjusted to a simple Dallas game plan, and it remains to be seen how effective he can be if the game plan doesn't open up.
Graham Gano will look to continue his hot streak after sinking both of his field goals last week in Sunday’s matchup with the Bucs.
Mike Evans will be a top wide receiver this week if he gets anywhere close to the 17 targets he saw last week against the Panthers tough secondary.
Michael Vick will be the starting quarterback for the Pittsburgh Steelers with Ben Roethlisberger injured, and though he doesn't have much experience in the offense he has awesome weapons and a good match-up this week against a Baltimore Ravens defense that has given up 350+ yards and multiple passing touchdowns in each of their last two games.
Jermaine Kearse is on pace for a career season despite a catchless Week 2, and faces a Lions defense Monday that has allowed five receivers to top 74 yards in three weeks.