LeGarrette Blount has scored in all but one game this season, and he has three 100-yard rushing outputs to his name in 2016, and faces a Buffalo defense on Sunday that's allowing 125 rushing yards per tilt, which is 27th in the NFL.
DeMarco Murray might have to share playing time with Derrick Henry more than usual in Week 8, which poses a short turnaround for the Tennessee Titans who play Thursday night, but he should be the team's best weapon against the Jacksonville Jaguars, who rank 18th in rushing defense.
Matt Forte broke out of a season-long slump last weekend and should take advantage of a questionable Cleveland Browns rushing defense on Sunday that's allowing 139.9 yards per game on the ground in 2016.
Christine Michael has topped 50 yards every week, and that trend's unlikely to stop Sunday against the 23rd-ranked Saints run defense.
Ezekiel Elliott will be fresh off a bye and going for his fifth straight game with over 130 rushing yards on Sunday Night Football against the Eagles.
Jacquizz Rodgers may not reach 100-yards for his third-consecutive game, whether or not Doug Martin returns, but will face a plus-matchup on Sunday against the Raiders, who’ve allowed three 100-yard rushers this season.
Devonta Freeman will hope the Packers’ defense gives way this Sunday like they did against Ezekiel Elliot (157 yards rushing), as opposed to the 166 yards they’ve given up to the other five other lead rushers have combined for this season.
David Johnson has 82 carries for 381 yards over the past three weeks, and even Carolina's seventh-ranked run defense is unlikely to slow him down.
Giovani Bernard will have a Week 8 tilt against Washington after touching the ball at least 15 times in each of his last three contests.
James White has three receiving touchdowns over the past two games, but faces a Buffalo defense on Sunday that's yielded just four throwing scores in 2016, which is tied for first in the league.
Spencer Ware continues to be the Chiefs' leading backfield option despite the return of Jamaal Charles, and faces a Colts defense Sunday that's giving up 118.6 rushing yards a game, 25th in the league.
Chris Thompson managed 113 yards on 19 touches last week, and should once again be involved out of the Redskins backfield Sunday against the Bengals.
Matt Asiata has seen his work in the passing game increase, and could be in for a bigger role if Jerick McKinnon's ankle injury lingers into a Monday night matchup with a Bears defense that ranks 17th against the run.
Darren Sproles will serve in his usual role as a change-of-pace receiving back Sunday in Dallas.
Frank Gore remains healthy as the Indianapolis Colts deal with injuries to other skill players entering Week 8 against the Kansas City Chiefs, who rank 22nd in rushing defense and 19th in passing yards per game allowed to running backs.
Latavius Murray scored twice last week in his return from a toe injury, and now faces a Buccaneers defense allowing 113.2 rushing yards a game, 20th in the league.
Lamar Miller banged up his shoulder in Week 7 and is questionable entering the Houston Texans' home game in Week 8 against the Detroit Lions.
Jeremy Hill will face a Washington defense in Week 8 that’s allowed six different running backs to score rushing touchdowns against them in 2016.
Melvin Gordon had his third multi-touchdown game of the season last week, and now faces a Broncos defense allowing 116.6 rushing yards a game, 22nd in the league.
Chirs Ivory gets significant playing time behind lead back T.J. Yeldon, but the Jacksonville Jaguars' underwhelming rushing offense ranks 30th in the league entering Week 8 on Thursday night against the Tennessee Titans.
Wendell Smallwood continues to mix in on a handful of plays per game, but his role Sunday in Dallas will be small.
Alfred Blue had his most playing time of the season in Week 7 due to a Lamar Miller shoulder injury and could emerge as the lead back for the Houston Texans in Week 8 against the Detroit Lions, pending Miller's status.
Jerick McKinnon labored through an ankle injury last week, and running behind a poor offensive line he could give carries away to the more powerful Matt Asiata in Week 8 against a mediocre Bears rush defense that allows 107.0 yards per game on the ground.
If he can return from his hamstring injury, Doug Martin will get a crack on Sunday against the Raiders’ bottom-five run defense that’s allowed three 100-yard rushers this season.
Dwayne Washington would have an inviting opportunity against a Texans defense that has allowed 10 rushing scores, the second-highest total in the league, should he be able to suit up after missing three games due to an ankle injury.
C.J. Anderson is coming off his first 100-yard game of the season, but has a tough matchup Sunday against a Chargers defense allowing 90.1 rushing yards per game, eighth in the league.
Devontae Booker scored his first career NFL touchdown in Week 7 and continues to see his workload increase, but has a tough matchup Sunday against a Chargers defense allowing 90.1 rushing yards per game, eighth in the league.
Mark Ingram likely won’t get the volume to have a big day on the ground on Sunday against the Seahawks, who haven’t allowed more than 51 yards rushing to anyone with fewer than 20 carries—a mark Ingram’s yet to hit this season.
Ryan Mathews doesn't see the same workload as most lead backs, which limits his value Sunday against the 10th-ranked Cowboys run defense.
Justin Forsett faces an uncertain role with the potential return of Dwayne Washington and Theo Riddick in Week 8 against a weak Texans rush defense that allows 135.4 yards per game.
Isaiah Crowell will have a Week 8 tilt against the Jets who have a defense that has held every running back they’ve faced, except David Johnson, to 75 or fewer rushing yards.
Duke Johnson will take on the Jets this Sunday, as he’ll look to gain yardage as a receiver against the unit that’s allowed at least 27 receiving yards to four different running backs this season.
Jonathan Stewart will look for room to run on Sunday against the Cardinals, who allowed Christine Michael to go for just 52 yards in 75 minutes and have allowed just four rushing touchdowns to opposing running backs this season.
Threes are wild for T.J. Yeldon, who's averaging 33.3 yards per game and 3.3 yards per carry entering Week 8 against the Tennessee Titans' sixth-ranked rushing defense.
Tevin Coleman left last week's game with a hamstring injury, and he faces long odds to be ready for Sunday's game against the Packers.
With the Tennessee Titans having little prep time in Week 8 against the Jacksonville Jaguars on Thursday, Derrick Henry may be asked to share more of the backfield snaps with DeMarco Murray.
Matt Jones's fumbling issues have allowed Chris Thompson to start siphoning off more of his workload heading into Sunday's London game against the Bengals.
Mike Gillislee would be in line for an expanded role should LeSean McCoy miss Sunday's game due to a hamstring injury, though the New England Patriots are allowing just 92.3 yards per game on the ground, which is 11th in the NFL.
Bilal Powell took a backseat to Matt Forte last weekend, but could see additional touches if Sunday's game gets out of hand against the abysmal Cleveland Browns, whose defense is allowing a total of 425.6 yards per game, which is 31st in the NFL.
Jordan Howard has only 56 yards on 22 carries over the last two weeks while Ka'Deem Carey has seen an increase in carries, and now faces a Vikings defense that ranks third against the rush, allowing 81.7 yards per game.
Knile Davis is likely to see more than the two carries he had last week with more practice reps under his belt, but will play second fiddle to Ty Montgomery against an 11th-ranked Falcons rush defense that is allowing only 91.9 yards per game on the ground.
Eddie Lacy has been placed on injured reserve following ankle surgery, and it's uncertain whether he'll return again this season.
Zach Zenner will at best split snaps with Justin Forsett on Sunday against the Texans, but a potential return from either Dwayne Washington or Theo Riddick would push him further down the pecking order for touches against a vulnerable 29th-ranked rush defense.
DeAndre Washington saw just six touches last week with Latavius Murray back in the lineup, and figures to see a small workload again Sunday against a Buccaneers defense allowing 113.2 rushing yards a game, 20th in the league.
Theo Riddick did not practice over the last two weeks due to an ankle injury, and his status for Week 8 against the Houston Texans is uncertain.
Jamaal Charles barely got onto the field in Week 7, and until he proves that his surgically-repaired knee can handle a significant workload, he'll be tough to trust, even against a Colts defense Sunday that's giving up 118.6 rushing yards a game (25th in the league.)
LeSean McCoy had to leave Sunday's game early due to a nagging hamstring injury, and his status remains uncertain heading into this weekend's clash with the New England Patriots.
Reggie Bush scored a touchdown this past Sunday, but it was on his lone carry of the game, and Mike Gillislee would be the first in line to take over rushing duties on Sunday against the Patriots if LeSean McCoy (hamstring) misses time.
Ka'Deem Carey has outperformed Jordan Howard over the last two weeks, seemingly earning himself an equal role in the Bears' backfield, but faces a third-ranked Vikings run defense Monday that is allowing only 81.7 rushing yards per game.
James Starks is likely to be sidelined at least three more weeks following knee surgery.