DeSean Jackson's big play ability makes him a strong play Sunday against a 25th-ranked Browns pass defense that has given up more than its fair share of long gains.
Marvin Jones is averaging 22.7 yards per catch and has popped for at least one catch of 30-plus yards every week heading into a matchup against a Bears defense that is allowing only 214 yards per game through the air.
Pierre Garcon has been outplayed by both DeSean Jackson and Jamison Crowder among Redskins wide receivers, but could still put up big numbers Sunday against Cleveland's 25th-ranked pass defense.
John Brown will look to follow last week's 70-yard performance with another strong effort Sunday against a Rams team that gave up 94 yards per game to him last season.
Terrelle Pryor will face Washington on Sunday, and it’s possible that he’ll continue to see snaps as a Wildcat quarterback, which could give him major upside this week.
Allen Robinson asserted himself in the offense in Week 3 (two TDs) and looks to continue that in Week 4 against the Indianapolis Colts, who rank 30th in scoring defense.
T.Y. Hiltons' breakout in Week 3 was a welcome sign and points to similar production in Week 4 against the Jacksonville Jaguars, who have been stout against the pass but have allowed 35 catches for 714 yards to Hilton in eight career games.
A.J. Green has a Thursday matchup against a Dolphins’ defense that coughed up eight receptions for 144 yards to Terrelle Pryor last week.
DeAndre Hopkins and the rest of the Houston offense had a tough Week 3 and will look to get back in the win column against a disappointing Tennessee Titans, who have allowed 186 yards per game to wide receivers.
Cole Beasley doesn't make many big plays, but rookie quarterback Dak Prescott should continue to look for him early and often Sunday against the 49ers after completing 20 passes for 213 yards to him through three weeks.
Antonio Brown will face the Chiefs on Sunday night after torching this defense for 124 last year in a game that backup quarterback Landry Jones started.
Travis Benjamin has averaged 19.7 yards per catch over the last two games and should be explosive once again Sunday at home against a Saints defense allowing nearly 300 passing yards a game so far.
Jamison Crowder already has 16 catches for 175 yards and two touchdowns this season, and likely won't slow down Sunday against a Browns team allowing 294.3 passing yards per game.
Alshon Jeffery has not scored in three games this year, but faces a Lions defense which has allowed a league-high 10 touchdown passes and which he's scored against in each of their last three meetings.
Michael Floyd is one of three viable Cardinals receivers Sunday against a Rams defense that has skated by on weak competition thus far, but his status is uncertain early in the week as he's entered the league's concussion protocol.
Doug Baldwin will be limited by a questions under center for Seattle, but shouldn't be intimidated against the Jets on Sunday given cornerback Darrelle Revis' early struggles.
Dez Bryant has been a major disappointment thus far, and will probably have to settle for a secondary role in Week 4 as he nurses a leg injury with Dallas likely to feature the running game in San Francisco.
Demaryius Thomas broke through with a big game in Week 3 and could be productive once again Sunday against a Buccaneers secondary that has already allowed seven passing TDs through three games.
Emmanuel Sanders is coming off a huge Week 3 and could be productive once again Sunday against a Buccaneers secondary that has already allowed seven passing TDs through three games.
Victor Cruz has put up at least 70 receiving yards or a touchdown in every game this season, but Minnesota's ninth-ranked defense won't make extending that streak easy Monday night.
Torrey Smith's matchup with Dallas' 23rd-ranked pass defense Sunday isn't as enticing as it looks because he'll be defended by top cornerback Morris Claiborne.
Julio Jones’ calf needs to heal up quickly to prevent another duck of a performance in Week 4 against the tough Panthers defense, who've allowed the second-fewest fantasy points to opposing receivers this season.
Jeremy Kerley caught seven passes for 61 yards in his last home game, and has a tempting matchup Sunday against a Dallas defense that's allowing 290.0 passing yards per game.
Mike Evans had his first 100-yard performance of the season against the Rams and will look to replicate the success AJ Green found last week (eight receptions, 77 yards)on Sunday against the Broncos’ stingy secondary, who allowed the fewest fantasy points to wide receivers last season.
Stefon Diggs remains the Vikings' best chance at providing a big play, and should find room to operate Monday night against a Giants defense that is surrendering 262 yards per game.
Phillip Dorsett has just 57 receiving yards the last two weeks and hasn't yet scored a touchdown this season, but remains on the radar for Week 4 against the Jacksonville Jaguars because the Colts' No. 2 receiver Donte Moncrief (shoulder) will miss the next 4-to-6 games.
Steve Smith will have a Week 4 matchup against a Raiders’ defense he posted 10 receptions for 150 yards against when he faced them in 2015.
Can Will Fuller and the Texans make the necessary adjustments this week after the rookie was held to 31 yards in Week 3? They face a familiar team in the Tennessee Titans, who rank 11th in receiving defense.
Sterling Shepard has 233 receiving yards and two scores through three games, but the rookie faces his toughest test yet against Minnesota's ninth-ranked pass defense on Monday Night Football.
As the Titans' leading target, Tajae Sharpe deserves a look any week, but Week 4 should make owners ponder using him as a starter as the Titans face the Houston Texans, who rank first receiving defense.
With Brandin Cooks blanketed all night, Michael Thomas showed how valuable the Saints’ third receiver can be, en route to his third consecutive game with 50 or more yards to open his pro career and will look to replicate that success Sunday against the Chargers.
Kevin White has seen his target and catch totals increase weekly, and faces a Lions defense in Week 4 that gave up four touchdown passes last week and a league-high 10 touchdown passes through three games.
After missing last week with a toe injury, Willie Snead will look to return on Sunday against the Chargers, who’ve allowed 325 or more passing yards to each of their first three opponents.
Brandin Cooks was targeted eight times, but pulled in just two receptions for 13 yards against the Falcons and will look to find his form on Sunday against the Chargers, who allowed eight receptions for 174 yards to T.Y. Hilton last week.
Odell Beckham has trended up in every game thus far, and even a Monday night road matchup with Minnesota's stout defense is unlikely to slow the talented receiver down.
After his first no-catch game of his career, Kelvin Benjamin should get back on track in what promises to be a shootout on Sunday against the Falcons, who have allowed 10 touchdown passes this season.
Marqise Lee has managed to stay healthy and is averaging six targets, four catches and 47 yards through three games entering a Week 4 matchup against the Indianapolis Colts' 26th-ranked receiving defense.
Allen Hurns is finding it hard to repeat last season's success, but some of that can be traced to the poor start of quarterback Blake Bortles. Week 4 brings some hope as Jacksonville faces the Indianapolis Colts and their 26th-ranked receiving defense.
Jarvis Landry found the end zone for the first time in 2016 last weekend and will face a Cincinnati Bengals defense on Thursday that has allowed the second-most passing touchdowns this season.
Julian Edelman may struggle if Jacoby Brissett lines up under center Sunday against the Bills, as the game plan will be geared more towards running the football, though Jimmy Garappolo may play despite a shoulder ailment.
DeVante Parker found the end zone last weekend and will face a porous Cincinnati Bengals defense in Week 4 that has allowed nine touchdown passes in three games in 2016.
Jeremy Maclin is coming off his worst game of the season in Week 3, but should be more productive Sunday against a Steelers defense that ranks 31st in passing yards allowed so far.
Larry Fitzgerald failed to find pay dirt last week, but is still quarterback Carson Palmer's favorite target heading a Week 4 home showdown with the Rams.
Mike Wallace have a Sunday contest against the Raiders who have allowed three different wide receivers to post at least 106 yards and a touchdown against them in 2016.
Breshad Perriman will face the Raiders on Sunday, after catching just five of his 11 pass targets on the season.
Kendall Wright missed a third straight game in Week 3, but had practiced last week and will be full participant this week. It looks like he'll be available for Week 4 against the Houston Texans, which should bolster Tennessee's dismal passing attack.
Adam Humphries broke the 100-yard barrier against the Rams, but could struggle to replicate those stats against a Broncos secondary that allowed just 189 passing yards last week to the Bengals.
Mohamed Sanu was once again a non-factor for chunks of last weekend’s game (three receptions for 31 yards) as the balanced Falcons offense hasn’t yet utilized the former Rutgers standout and could struggle this Sunday against the Panthers’ tough defense once again.
Amari Cooper did little with his nine targets in Week 3 and now faces a Ravens secondary Sunday that's allowed the third-fewest passing yards in the league so far this season.
Danny Amendola caught just two passes last week and will likely struggle with either dinged up quarterback under center as he faces the Bills on Sunday.