Shane Vereen led the Giants with 14 carries in Week 2, and that level of volume coupled with his ability to contribute as a receiver makes the former Patriot an enticing play Sunday against a Washington team giving up 408.5 yards per game.
David Johnson split carries with Chris Johnson in Week 2, but his ability to contribute as both a runner and a receiver makes him a strong option Sunday against a Bills team that just got gashed for 100 yards and three scores by the similarly-skilled Matt Forte.
LeGarrette Blount should be fed early and often against the Houston Texans as the New England Patriots will be starting their third-string quarterback in Jacoby Brissett.
DeMarco Murray is making a bigger splash as a receiver (12 receptions, two TDs) than a runner, but could go off in either category in the Titans' Week 3 matchup against the Oakland Raiders, who rank 21st in rushing defense (113.5 ypg) and last in receiving defense (409.5 ypg).
Ezekiel Elliott should be able to find the end zone for the third straight game Sunday against a Bears defense that just gave up two scores to Philadelphia's Ryan Mathews, as long as fumbling issues don't put him back in the dog house.
Matt Forte rushed for 100 yards and three touchdowns last week and has a favorable matchup in Week 3 with the Kansas City Chiefs, a squad allowing 126 rushing yards per game in 2016.
Melvin Gordon had another big game Week 2, and with Danny Woodhead now out for the year, he should see plenty of touches Sunday on the road against a Colts defense allowing 125 rushing yards per game so far.
Jay Ajayi would be in line for an expanded workload against a Cleveland defense allowing 106.5 yards per game in a Sunday matchup if Arian Foster is sidelined with a groin injury
Frank Gore scored his first touchdown of the season Week 2, but that's been the only highlight as he prepares for a Week 3 home game against the San Diego Chargers, who rank 7th in rushing defense (76.0 ypg).
Lamar Miller's been a workhorse through two weeks with 53 rushing attempts (2nd in NFL), but has a tough Week 3 on the road against the New England Patriots, who allow just 81 rushing yards per game (9th in NFL).
Eddie Lacy faces a Lions defense Sunday that is allowing a league-high 5.1 yards per carry and finished Week 2 with only two healthy linebackers, but he has seen only 26 carries through two games.
Rashad Jennings and the running game will likely take a back seat to Eli Manning's passing attack in what would otherwise be a favorable Week 3 matchup with a Redskins defense that's allowing 32.5 points per game.
Latavius Murray has gotten into the end zone in each of his first two games this season, but could struggle to make it three in a row Sunday on the road against a Titans defense that has yet to allow a rushing TD.
Theo Riddick could see an expanded role in the rushing attack if Ameer Abdullah misses Sunday's contest at the Green Bay Packers, the league's top-ranked rush defense, but would likely give way to Dwayne Washington for goal line work.
Isaiah Crowell will be on the road Sunday to face a Dolphins defense that was shredded by LeGarrette Blount for 123 yards and a touchdown in Week 2.
Alfred Morris has been granted an increased opportunity thanks to Ezekiel Elliott's fumbling issue, but he's still playing second fiddle heading into Sunday's matchup with a generous Bears run defense.
Darren Sproles' pass-catching ability makes him a fine play Sunday against a Steelers team that ranks second against the run.
Christine Michael has vastly outplayed teammate Thomas Rawls through two weeks, making him the slightly more appealing option Sunday against a 49ers defense that's allowing 120.5 rushing yards per game.
Jerick McKinnon is in line to start in Week 3 in the likely absence of Adrian Peterson, but would surrender goal line work to Matt Asiata while facing a Panthers defense that is allowing just 3.9 yards per carry.
Mark Ingram was mostly a non-factor once again last week, seeing just 13 touches and turning them into 47 yards, but he should find more space Monday against a Falcons defense that gave up 6.2 yards per carry to the Raiders.
DeAngelo Williams will be on the road Sunday to face a tough Eagles front-seven, after piling up 303 combined yards and three touchdowns in the first two games of 2016.
Chris Johnson led the Cardinals in carries in a Week 2 blowout win, and could see another solid chunk of work Sunday against a Bills team that gave up three rushing scores last week.
C.J. Anderson has enjoyed a great start to the season in Gary Kubiak's run-oriented offense, but he faces stiff opposition Week 3 on the road against a Bengals defense yet to allow a rushing TD.
Jamaal Charles seems poised to make his 2016 debut Sunday after recovering from last season's knee injury, but his production could be limited against a Jets defense allowing 71.5 rushing yards per game so far, especially if he splits touches with Spencer Ware.
Terrance West will facing the Jaguars and Week 3 after he’s gained just 74 yards on 23 rushing attempts to start the season.
Dwayne Washington was the team's preferred short-yardage back before an injury to Ameer Abdullah, and could see an expanded role Sunday should Abdullah miss the contest against the Packers' top-ranked rush defense.
Jeremy Hill will be at home on Sunday to face the Broncos’ rush defense that has allowed 240 yards through two games, but Hill only has 53 yards and one touchdown on 20 carries to start the season.
Matt Asiata seems likely to handle goal line work in the probable absence of Adrian Peterson, and faces a Panthers defense that has allowed three rushing touchdowns in two weeks.
Thomas Rawls' leg contusion isn't serious, but his ineffectiveness through two weeks suggests teammate Christine Michael will be the stronger running back option Sunday against a 49ers defense that's allowing 120.5 rushing yards per game.
Charles Sims could only muster 28 yards despite being the featured back for more than a half thanks to Doug Martin’s injury, and may need to carry the load on Sunday against the Rams, who allowed 2.8 yards per carry against the Seahawks.
Giovanni Bernard will be on his home field Sunday to take on the Broncos and their stifling defense, a unit he rushed for 14 yards on eight carries to go with four receptions for 29 yards when he faced them in 2015.
Matt Jones' stock is on the rise after he scored while shouldering the rushing load in Week 2, but Sundays' meeting with the Giants' fourth-ranked run defense likely won't show that.
Josh Ferguson will likely see more opportunities when the Colts get into a shootout with opponents, something that often happens due to a porous defense and is a real possibility Week 3 against the San Diego Chargers, the league's 29th-ranked receiving defense.
Duke Johnson will face the Dolphins on the road in Week 3, though he’s only had six rushing attempts to 30 for teammate Isaiah Crowell so far this season.
Tevin Coleman scored the only rushing touchdown for the Falcons last week, but was out-touched 17-to-14 by Devonta Freeman in one of the more intriguing (and frustrating for fantasy owners) time shares in the NFL, making him a highly volatile option Monday against the Saints.
Derrick Henry jumped up from 21 snaps/five carries in Week 1 to 31 snaps/nine carries in Week 2, something that bodes well for Week 3 against the Oakland Raiders as the Titans work a two-back attack with the rookie joining lead back DeMarco Murray.
Todd Gurley has struggled while consistently facing stacked fronts that aren't afraid of an impotent passing game, and things may not get much better in Week 3 against a Buccaneers defense that has held opponents to 76.5 rushing yards per game.
Justin Forsett will be on the road this Sunday to take on the Jaguars, a defense that has allowed at least 4 yards per carry to both Eddie Lacy and Melvin Gordon in their first two games.
Jordan Howard had 31 yards on five touches in Week 2, and could be in line for a major leap in usage against the Cowboys with Ka'Deem Carey possibly sidelined by a hamstring injury and Jeremy Langford struggling to produce.
Fozzy Whittaker will look to repeat his 100-yard performance from last week against a stingy Vikings defense that allowed just 50 rushing yards to Eddie Lacy last weekend, though he could share snaps with Cameron Artis-Payne and Mike Tolbert.
LeSean McCoy has yet to break 60 yards rushing in a game this season and will square off on Sunday against a feisty Arizona Cardinals defense that is currently ranked 10th in the NFL in rushing yards allowed per contest.
Devonta Freeman out-rushed Tevin Coleman 17-to-12 last week but didn’t receive a single target in the passing game, which hampers his once-high value in PPR formats as he faces a Saints defense Monday that allowed just 2.0 yards per carry last weekend to the Giants.
T.J. Yeldon will serve as the Jaguars' lead back while Chris Ivory (medical condition) remains sidelined, but has just 107 combined yards entering Week 3 against the Baltimore Ravens, who allowed 145 yards rushing (6.3 ypc) against the Browns last week.
Ka'Deem Carey is in line to take reps away from a struggling Jeremy Langford against the Dallas Cowboys, but is no guarantee to suit up due to a hamstring injury that forced him from Monday's game against the Eagles.
Devontae Booker was fairly productive with his 10 touches in Week 2, but even if he sees a bigger workload going forward, he'll have a tough time Sunday against a Bengals defense that has yet to allow a rushing TD.
Kenyan Drake could see increased touches if Arian Foster is sidelined against the Cleveland Browns on Sunday, though Jay Ajayi would still remain ahead of Drake on the depth chart.
Denard Robinson played 12 snaps in last week's blowout, but will have a hard time getting snaps if Chris Ivory (general medical issue) is ready to roll Week 3 against the Baltimore Ravens.
Spencer Ware will return to a supporting role with Jamaal Charles set to make his 2016 debut Sunday, but he could still see significant touches Week 3 as the Chiefs ease Charles back into action.
James White has just 12 touches through two games, as LeGarrette Blount remains the primary workhorse for the New England Patriots out of the backfield.
Doug Martin is a question mark going into Sunday’s matchup with the Rams after injuring his hamstring against the Cards last weekend, but won’t be a strong play regardless against a defense that allowed 2.8 yards per carry last weekend.