Isaiah Crowell has a Sunday contest against a Washington defense that has allowed six touchdowns to running backs through three games this season.
Jordan Howard has an inviting matchup against a Lions defense which is allowing a league-high 5.1 yards per carry, and would see a boost in appeal should Jeremy Langford (ankle) miss the contest.
Jerick McKinnon out-touched Matt Asiata 17-to-7 in the team's first game without Adrian Peterson, but faces a stern test Monday night against a Giants' fifth-ranked rush defense that is allowing only 77.3 yards per game.
Charles Sims will be a strong play for the Bucs on Sunday against the Broncos after they allowed 143 yards and 4.9 yards per carry to the Bengals last weekend.
Alfred Morris has vultured a couple touchdowns, but Ezekiel Elliott is still the clear go-to running back in Dallas heading into Sunday's plus matchup with the 49ers.
Dwayne Washington is the best bet in a limited rushing offense, and faces a Bears defense that ranks second-to-last against the run, allowing 142.7 yards per game
Fozzy Whittaker will look for more than five carries as he’s just a week removed from his 100-yard performance against the 49ers for Sunday’s divisional matchup against the Falcons, who allowed the sixth-most fantasy points to opposing running backs in 2015.
Duke Johnson will face Washington on Sunday where he’ll look to have a fourth straight game with at least 50 total yards.
Cameron Artis-Payne averaged 3.9 yards per carry against the Vikings and should find more room to run Sunday against the Falcons, who allowed the sixth-most fantasy points per game to opposing running backs last season.
Orlean Darkwa could play a major role on Monday Night Football in Minnesota with Rashad Jennings (thumb) questionable and Shane Vereen (triceps) done for the year.
James White has been underwhelming in the Dion Lewis role and will likely continue to be underutilized Sunday against the Bills.
Powell had 10 touches for 71 yards last weekend, though he'll likely find little room to roam against a Seattle defense allowing a league-low 250.3 yards per game.
Isaiah Pead had five carries in last weekend's game, though Kenyan Drake had the most carries in the absence of Arian Foster, while Jay Ajayi scored a rushing touchdown, and he'll try to earn more work Thursday against the Bengals.
Matt Asiata was out-snapped 36-to-19 by Jerick McKinnon, receiving only seven touches in the team's first game without Adrian Peterson, and will need goal line work to provide value Monday night against the Giants fifth-ranked rush defense.
Alfred Blue played just two snaps on the final drive of Houston's loss to the Patriots in Week 3 and will continue to take a heavily subordinate role to Lamar Miller in Week 4 against the Tennessee Titans.
Jonathan Grimes had his most use of the season last week, primarily in the passing game, but like the rest of the Houston running backs, he's buried behind starter Lamar Miller as the Texans prepare for a Week 4 home game against the Tennessee Titans.
Kenyan Drake actually had the most touches out of the backfield last week, though Jay Ajayi scored a touchdown in the absence of Arian Foster, and a timeshare looms with Isaiah Pead in the mix as well as he faces the Bengals on Thursday night.
Antonio Andrews is buried on the depth chart behind DeMarco Murray and Derrick Henry entering Week 4 against the Houston Texans.
Jay Ajayi had a touchdown run in the absence of Arian Foster, though Kenyan Drake actually had more touches out of the backfield, and a timeshare looms with Isaiah Pead in the mix as well when he faces the Bengals on Thursday.
Tyler Ervin was nowhere to be found on offense last week and had a rough game on special teams, but remains the lead return man entering Week 4 against the Tennessee Titans.
Ameer Abdullah is on injured reserve due to a foot injury, leaving Theo Riddick and Dwayne Washington to carry the load for the Lions backfield.
DeAndre Washington looked explosive in his limited touches once again in Week 3, but his fantasy value has a low ceiling as long as Latavius Murray remains the starter in Oakland.
Adrian Peterson is on injured-reserve while recovering from surgery to repair a torn meniscus.