DeAngelo Williams turned in 153 total yards and two touchdowns on 23 touches in Week 16 against the Baltimore Ravens, his seventh game with at least 110 total yards and/or a touchdown in eight starts, and in Week 17 he has an excellent match-up against a Cleveland Browns rush defense that ranks dead last in the NFL with 135 yards allowed per game.
Adrian Peterson showed no signs of a nagging ankle injury last Sunday, and will be out for revenge against a 21st ranked Packers defense that is allowing 114.2 yards per game, but held Peterson to 45 yards in Week 11.
Devonta Freeman went for 100 yards rushing and 56 receiving in the Falcons’ last matchup with the Saints and should break the 1,000-yard mark rushing for the season.
James White has scored in four-straight games and faces a Miami Dolphins defense allowing 25.3 points per game, which is tied for 23rd in the NFL.
Johnson made the most of his limited chances (nine carries, 39 yards and a TD in addition to three catches for 88 yards) but a pair of defensive TDs in the third quarter opened up the floodgates and sent Johnson to the bench by the fourth quarter but expect a full workload in Week 17 against Seattle as Arizona can still secure home field throughout the playoffs.
Gurley (19 carries, 85 yards and a TD) was able to make the most of an ugly matchup on the road in Seattle in Week 16 as the Rams got out to an early lead and figures to see a heavy dose of action against the 49ers in Week 17.
Cameron Artis-Payne will likely be called upon to start his third straight game and is a solid option against a mid-tier Bucs defense with his 4.5 yards per carry.
Isaiah Crowell rushed 16 times for 88 yards and a touchdown on Sunday, his second big effort in three games, but in Week 17 he has a tough match-up against a Pittsburgh Steelers defense that allows only 91.5 yards per game on the ground (sixth in the NFL) and that has given up only six rushing touchdowns all season (second in the NFL).
Duke Johnson rushed eight times for 26 yards and added three receptions for 15 more yards on Sunday but was outproduced by rival Isaiah Crowell (16 rushes, 88 yards, one touchdown), and in Week 16 he has a match-up against a pass-heavy Pittsburgh Steelers team that has to win to make the playoffs and has a weak pass defense (278.2 passing yards allowed/game, 30th in NFL).
Charles Sims has been excellent in limited work this season and could be in line for more touches after 117 yards on just seven touches last week with a touchdown.
Michael struggled to find much running room against the Rams in Week 16, finishing with just six yards on six carries, but he figures to lead the Seattle ground game in a Week 17 road tilt against the Cardinals unless Marshawn Lynch makes a surprise return for the season finale.
Lamar Miller continues to be one of the more under-utilized backs in the NFL, though he did find the end zone in the first meeting with the New England Patriots.
Rashad Jennings dominated the carries for a third straight week (14 totes for 74 yards) and added 62 yards on two catches, making him a solid play given his matchup against the Eagles.
Jeremy Langford could return to a featured back role if Matt Forte is forced to sit out due to a back injury, but faces a Lions defense that has allowed only two opposing rushers to top 72 yards since Week 10.
C.J. Anderson saw just 10 touches in Week 16 but scored his fourth touchdown of the season, and faces a Chargers defense Sunday that's in the bottom five in the league in rushing TDs allowed (15) and yards per carry allowed (4.7).
Bilal Powell outgained Chris Ivory by a substantial margin this past Sunday, and remains the better play against the Buffalo Bills.
Theo Riddick has at least five catches in five of his last seven games and could snap a four-game scoreless streak against a Bears defense that has allowed six receiving touchdowns to running backs.
Eddie Lacy faces a Vikings defense which he rumbled for 100 yards against in Week 11 but has only allowed two rushing touchdown in their last seven games.
Javorius Allen had a huge bounce-back game in Week 16 with 114 total yards and a touchdown against the Pittsburgh Steelers, and in Week 17 faces a Cincinnati Bengals rush defense that is seventh in the NFL with 94.5 yards allowed per game, but they are 20th in the NFL in passing yards allowed which still plays to one of Allen's strengths.
Charcandrick West was unimpressive in Week 16's win over the Browns, but should again see the majority of backfield touches Sunday against the Raiders as the Chiefs try to win the AFC West.
Latavius Murray topped 100 combined yards in last week's win over the Chargers for the first time since Week 8, and he'll take on a Chiefs defense Sunday that he ran for 86 yards and a TD against in their last matchup.
With a ton of uncertainty at quarterback, the Indianapolis Colts are likely to ride the legs of Frank Gore in their Week 17 game against the Tennessee Titans, who rank 17th in run defense (111.3 ypg).
Jeremy Hill rushed 19 times for 63 yards and lost two yards on his two receptions (on two touches) on Monday night against the Denver Broncos, and in Week 17 faces a Baltimore Ravens run defense that held him to only 21 yards on 12 carries back in Week 3.
Tim Hightower, who was out of the NFL for three years, had more than 120 yards and two touchdowns last week and faces the Falcons’ bottom-five run defense this week.
Alfred Blue has returned to his spot atop the Houston Texans' running back depth chart entering a Week 17 home game against the Jacksonville Jaguars, who rank 13th against the rush (103.3 ypg).
Doug Martin has developed a case of fumblitis of late, losing five this season after one in his first three seasons combined.
Darren McFadden rushed 19 times for 99 yards in the loss to Buffalo and will see at least token action in the finale in his pursuit of a 1000-year season.
Giovani Bernard rushed eight times for 14 yards and added four receptions on five targets for 29 more yards on Monday but was out-touched and out-gained by Jeremy Hill, who totaled 61 yards on 21 touches, and in Week 17 has a match-up with a Baltimore Ravens defense that he burned for 83 total yards on 16 touches back in Week 3.
Ronnie Hillman once again appears to be in a timeshare with C.J. Anderson, but gets to face a Chargers defense Sunday that's in the bottom five in the league in rushing TDs allowed (15) and yards per carry allowed (4.7).
Pierre Thomas was unearthed for 89 total yards against the Eagles and could see a larger than expected role in the finale with the Redskins having wrapped up the division.
Harris led the San Francisco running game (11 carries, 73 yards) in a Week 16 loss and figures to lead the San Francisco ground game in a Week 17 home game against the Rams if you're desperate for help.
Joique Bell has scored in consecutive weeks but continues to share snaps with Ameer Abdullah and Theo Riddick and faces a Bears defense that has allowed the ninth-fewest rushing touchdowns (9) on the year.
Chris Polk is part of the Houston Texans' backfield committee but remains secondary to starter Alfred Blue for Week 17 against the Jacksonville Jaguars.
Karlos Williams split touches with Mike Gillislee though still managed nearly 100 yards from scrimmage along with a touchdown; however, the New York Jets have been stout against the run, and LeSean McCoy may also be returning from injury.
Chris Ivory is essentially splitting carries with Bilal Powell, who has been the far more productive back over the last month.
Shane Vereen had a disappointing two catches in the loss to Washington after racking up eight catches and a touchdown the week prior.
Alfred Morris dominated the carries against Philadelphia with 17 (Pierre Thomas had just four) but picked up just 49 yards and wasn't involved in the passing game.
Williams actually led the Arizona ground game with 44 yards rushing in a Week 16 rout of the Packers but he'll take a back seat to both David Johnson and Andre Ellington in a Week 17 matchup against Seattle.
David Cobb continues to get some carries out of the Tennessee Titans backfield and, as a fifth-round draft pick who the franchise believes in, may get an increased role in the team's season-finale in Week 17 against the Indianapolis Colts, who rank 24th in run defense (121.0 ypg).
Ellington returned from his turf toe injury and played well in a limited role (seven carries, 40 yards) in a Week 16 win but figures to take a back seat to rookie David Johnson again in Week 17 as the Cardinals look to secure home field advantage in the NFC playoff picture against Seattle.
DeMarco Murray had just five carries against Washington but did manage to find the end zone for the first time since early November.
Mike Gillislee split touches with Karlos Williams though still managed over 100 yards from scrimmage along with a touchdown; however, the New York Jets have been stout against the run, and LeSean McCoy may also be returning from injury.
Hayne saw a season-high 14 touches in a Week 16 loss and could see a similar workload in the season finale against the Rams as the 49ers look to see what they might have in the former rugby star.
Jonathan Grimes is part of the backfield mix, but will take a subordinate role to Alfred Blue when the Houston Texans play the Jacksonville Jaguars in Week 17.
Kyle Juszczyk grabbed five receptions for the second consecutive week in Week 16, and in Week 17 he will face a Cincinnati Bengals pass defense that has allowed 246.3 yards per game (20th in NFL) but only 17 touchdown passes (tied for third in the NFL).
Ka'Deem Carey has scored in two of his last four games, and could see an expanded role against the Lions should Matt Forte miss the contest due to a back injury.
Chris Thompson had just one touch in the win over Philadelphia but found the end zone and could be more involved if the Redskins rest some starters in the finale.
Brandon Bolden saw the most touches of any New England running back this past weekend, though managed just 60 yards from scrimmage in the process.
Denard Robinson has filled in for T.J. Yeldon the last two weeks, but shared the running back duties with Jonas Gray, a situation that could play itself out in Week 17 when the Jacksonville Jaguars play the Houston Texans.
Jonas Gray was the Jacksonville Jaguars' leading rusher last week and put himself into the mix as T.J. Yeldon (knee) is questionable for a Week 17 matchup against the Houston Texans.