Jordan Matthews is the clear-cut top receiving option in Philadephia heading into what promises to be a pass-heavy game Sunday against a Steelers defense that's allowing 347.5 passing yards per game.
Larry Fitzgerald already has three touchdowns this season, and is primed for another strong performance Sunday against a Bills team that allowed three Jets receivers to top 90 yards last week.
DeAndre Hopkins scored a touchdown for the second straight game in last week's win over the Kansas City Chiefs and could extend that streak Week 3 against the New England Patriots, who rank 28th in passing defense (320.5 ypg).
Odell Beckham is off to a "slow" start with 12 catches for 159 yards through two weeks, but a Week 3 matchup with old nemesis Josh Norman and the Redskins is sure to light a fire under him.
DeSean Jackson's favorable history against the Giants suggests the boom-or-bust option is likely to produce Sunday after managing 66 yards and a touchdown in their last meeting.
Marvin Jones has been targeted at least 10 times in each of the season's first two games, providing at least 85 yards, heading into a matchup with a Packers defense that just surrendered 182 yards to Minnesota's Stefon Diggs.
Eric Decker has scored a touchdown in six-straight games dating back to last season, and the Jets may be without Brandon Marshall this weekend, as New York faces a Kansas City Chiefs defense allowing 23 points per game thus far in 2016, which is tied for 15th in the league.
Michael Floyd has settled in as Arizona's No. 2 wide receiver, which should be a valuable role Sunday against a Bills team that allowed two Jets receivers to top the century mark last week.
Victor Cruz looks to be fully back after two strong outings to open the season, making him a dangerous option Sunday against a Redskins team likely to focus on limiting teammate Odell Beckham.
Antonio Brown will be on the road to face an Eagles defense that gave up 34.5 yards per reception to Terrelle Pryor and Corey Coleman in Week 1.
Dez Bryant rebounded with 102 yards in Week 2, and his chemistry with rookie quarterback Dak Prescott should continue to grow on Sunday Night Football against a Bears team playing on a short week.
Julio Jones cracked the 100-yard mark on just five targets against the Raiders and should find even more space Monday against a depleted Saints’ secondary that allowed more than 350 passing yards last week to the Giants.
Jordy Nelson has scored in consecutive weeks while seeing 20 targets, and faces a depleted Lions defense that has allowed six touchdown passes in two games.
Travis Benjamin thrived last week as Philip Rivers' primary target, and has another potentially-great matchup Sunday on the road against an injury-ravaged Colts secondary.
Jarvis Landry should be able to exploit a porous Cleveland Browns passing defense in Week 3 that is allowing 286 passing yards per game in 2016.
Will Fuller has started his NFL experience with two straight 100-yard games and could easily make that three in Week 3 against the New England Patriots, who allowed two 100-yard receivers in last week's win over the Dolphins.
Nelson Agholor took a slight step back last week after scoring in the season opener, but he makes for an enticing option Sunday against Pittsburgh's 31st-ranked secondary.
Mohamed Sanu was a non-factor for large stretches of last weekend’s game against the Raiders (3-19-0), but should find more space Monday against a forgiving Saints secondary that has already allowed three different receivers to break the 85-yard barrier in 2016.
Cole Beasley is worth a look against a struggling Bears team in Week 3 after catching 13 passes for 140 yards over the first two weeks.
T.Y. Hilton is the Colts' most-targeted wideout through two games and has an opportunity to pad his stats Week 3 against the San Diego Chargers, the NFL's 29th-ranked receiving defense (346.0 ypg).
Adam Humphries was second on the team in receiving yards for the second straight week and will look to continue his production Sunday against the Rams.
Tyrell Williams will need to start catching more than half his targets if he wants to take full advantage of Keenan Allen's absence, but has a great matchup Sunday on the road against an injury-ravaged Colts' secondary.
Alshon Jeffery faces a Cowboys defense that is allowing 277 yards per game through the air, but could struggle to make plays downfield with Brian Hoyer set to start in place of the injured Jay Cutler.
Rishard Matthews, Tennessee's most significant offseason acquisition at wideout, has just seven catches for 66 yards entering Week 3 against the Oakland Raiders, who rank last in passing and receiving defense.
Randall Cobb has only 99 yards on 11 catches through two weeks, but faces an injury-depleted Lions defense that has given up 296 yards per game through the air and six touchdown passes in two games.
Michael Thomas was Drew Brees’ go-to target down the stretch last week and finished with four receptions for 56 yards on five targets, but could struggle Monday against the Falcons’ strong secondary.
Tajae Sharpe's production dropped off from Week 1 to Week 2, and he averages just 9.9 ypc, but he remains Tennessee's No. 1 wideout and will get plenty of attention Week 3 against the Oakland Raiders, who rank last in yards allowed to wide receivers (296.5 ypg).
Sterling Shepard has already proven capable of taking advantage of the favorable matchups that he'll see Sunday, with the Redskins focused on containing teammate Odell Beckham.
AJ Green will be at home in Week 3 to face a second-ranked Broncos secondary that he posted five receptions for 57 yards and a touchdown against in 2015.
Josh Doctson's involvement in the offense is on the rise heading into Sunday's matchup with a Giants secondary that allowed 298.9 yards per game last season.
Tavon Austin hasn't turned significant volume into much production this season, but a Week 3 date with a Buccaneers defense that allowed 32.0 points per game to two significantly better offenses offers some hope.
Marcus Wheaton (shoulder) will see if he’s healthy enough Sunday to face a shaky Eagles secondary that gave up four receptions for 137 yards to Terrelle Pryor and Corey Coleman in Week 1.
John Brown has caught only two passes through two weeks, but Sunday's matchup with a Bills team that allowed three receivers to top 90 yards last week offers a chance to regain the 2015 form that saw him top 1,000 yards.
Phillip Dorsett leads the Colts in receiving yards, averaging 24.8 ypc after two games, and could see extra looks Week 3 as Donte Moncrief (shoulder) is questionable for the game against the San Diego Chargers, who rank 15th in yards allowed to wideouts (162.5 ypg).
Quincy Enunwa left last week's game with a rib injury, but if healthy, could have a big opportunity if Brandon Marshall is sidelined with a knee injury on Sunday against a mediocre Kansas City Chiefs defense.
Allen Hurns is the Jaguars' leading receiver entering a Week 3 home game against the Baltimore Ravens, who rank first in receiving defense (185.5 ypc).
Amari Cooper has enjoyed a fast start to 2016, but may not be as productive Sunday on the road against a Titans defense that held the Lions' passing game in check Week 2.
Willie Snead led the fantasy charge last week by catching the Saints' only touchdown, and projects well at home Monday despite facing the above average cornerbacks of the Falcons.
Tyler Lockett should be good to go Sunday against the 49ers after spraining his knee last week, and could see more targets if Doug Baldwin (knee) is unable to suit up.
Allen Robinson is off to a slow start in 2016 and looks to break out Week 3 against what has been a stingy Baltimore Ravens defense, which allows the third-fewest yards to wide receivers after two weeks (113.5 ypg).
Stefon Diggs leads the league in receiving through two weeks and should be heavily targeted again with Adrian Peterson set to miss a contest against the Panthers' sixth-ranked passing defense.
Steve Smith will be on the road in Week 3 to face the Jaguars, a defense he posted five receptions for 37 yards against when he met them in 2014.
Brandin Cooks led the team in receptions (seven), targets (nine) and yards (68) last week but should be more productive against the Falcons on Monday, a defense that allowed 299 passing yards to Derek Carr and the Raiders (on 45 pass attempts).
Kelvin Benjamin had one of the best games of his career against the 49ers, but faces a much stiffer challenge Sunday against Trae Waynes and a physical Vikings secondary that held Aaron Rodgers to just 213 yards last week.
Davante Adams has three catches on seven targets in both games to date, and faces a Lions secondary that has allowed 296 yards passing per game and six receiving touchdowns.
Jamison Crowder scored Washington's first receiving touchdown of the season in Week 2, which makes him an enticing option in a high-volume passing offense Sunday against a Giants team that ranked dead-last against the pass in 2015.
Eli Rogers will take on the Eagles Sunday on the road, as he’ll try to take advantage of a secondary that gave up a number of big passing plays to the Browns in Week 1.
DeVante Parker should be able to build on last weekend's breakout performance on Sunday against a Cleveland Browns defense that is 20th in the NFL in terms of passing yards allowed per game.
Kenny Britt should be able to build on his team-leading 161 receiving yards against a Buccaneers defense that's allowing 318.5 passing yards per game, but the veteran isn't much of a threat in the red zone.
Jeremy Maclin posted disappointing numbers Week 2 considering his 15 targets, but he could be poised for a better game Sunday given how Darrelle Revis has struggled through the early part of 2016.