Dixon isn't going to break off many long gains, but he could be in for a heavy Week 5 workload against a questionable defense, as teammates LeSean McCoy (hamstring) and Karlos Williams (concussion) are both in danger of missing the game.
Over 600 yards the past two games, and gets an Atlanta pass defense yielding 30 yards per game in what could be a shoot out.
Gould has connected from at least 50 yards three times this season, and his nine made field goals is the second highest total in the league, and will face a Chiefs defense that allows 31.3 points per game, potentially setting him up for a busy afternoon.
Leonard Hankerson, now the No. 2 receiver on the high-octane Falcons offense, should have another good week against the Redskins after his first 100-yard receiving day since 2011.
Baldwin gets a favorable draw against a Bengals defense that has allowed the sixth-most passing yards per game (279.0) through the first four weeks of the season in a Week 5.
Johnson turned in a solid performance against the Rams in Week 4 (16 carries, 83 yards) but his value going forward will depend on his ability to keep his starting role with the return of Andre Ellington.
Royal's upside will tie directly to the availability of Alshon Jeffery, but facing a Chiefs defense that allows 296 yards and 31.3 points per game, there should be enough to go around for Royal.
Kaepernick will look to turn around his woeful season against the league's worst pass defense as the 49ers take on the Giants in Week 5.
With 18 targets the past two weeks, Crowder makes for a sneaky play with a good matchup if DeSean Jackson remains sidelined this week.
Should Jeffery return from a hamstring injury, he'll face a Chiefs defense that has eight opposing receivers top 80 yards in four games while allowing 11 touchdowns.
Zuerlein could benefit from a renewed ground game behind Todd Gurley in St. Louis but will have a tough road game against the Packers in Week 4.
Ryan Succop has reaped the rewards of the Tennessee Titans' improved offense and looks to build on that in Week 5 against the Buffalo Bills, who allow an average of 23 points per game.
Worthy of consideration now that the bye weeks have started given the comfy matchup against a suspect Atlanta pass defense.
While he may not catch 80-yard touchdown passes every week, C.J. Spiller gets a good matchup in PPR leagues against an Eagles team that's allowed more than 50 receiving yards to running backs per game.
Bradford will face a soft defense after last week's impressive second-half rally against the Redskins, but the Philadelphia offense still looks out of sync.
With so many of his teammates hobbled by injuries, Harvin could see some extra targets against a shaky Tennessee secondary.
Scored for the second straight week and spends another week as WR2 with the injury setback to Victor Cruz.
Allen Hurns has been a more consistent receiver in his second season with the Jacksonville Jaguars and he'll remain the number two target in Week 5 against the Tampa Bay Buccaneers.
Owen Daniels has an excellent chance of extending his touchdown streak to three games Sunday against a Raiders defense that's already allowed six tight end TDs in just four games.
Blake Bortles has shown improvement in his second year at the helm of the Jacksonville Jaguars' offense and enters Week 5 against a beatable Tampa Bay Buccaneers.
Heath Miller was held to a single reception for one yard in his first game with Michael Vick calling signals, and will have a chance to bounce back after an extra-long week of practice against a San Diego Chargers defense that is 25th in passing touchdown percentage allowed.
Foles and the Rams passing attack will face another tough test on the road against the Packers as he looks to build off of last week's three touchdown performance.
Rodgers is quietly becoming a third or fourth option in one of the league's best passing attacks, having scored twice in four weeks, but faces a Rams pass defense that has allowed only three receiving touchdowns and 235 yards per game.
Coming off of his first touchdown since October 16, 2014, Amendola remains fourth at best in the pecking order for targets from Tom Brady, making him hard to trust even against a Cowboys secondary that has allowed 307.5 yards per game in their last two contests.
The New Orleans defense provides favorable matchups for pretty much every offensive position, but Agholor is averaging just four targets per game.
Kearse hasn't found the end zone but has topped 75 yards receiving in three of his four games this year as Seattle takes on a Bengals defense that is allowing the sixth-most passing yards per game (279.0) in the league so far.
Harry Douglas is averaging just 3.3 yards per target in the Tennessee Titans' high-volume offense as he enters a Week 5 game against the Buffalo Bills, who have given up the third most touchdowns to wideouts this year.
Even if healthy, Jacob Tamme is not a great option in Sunday's matchup with the Redskins for a Falcons offense where 10.4 percent of receptions have gone to tight ends.
Going up against the league's 28th ranked pass defense offers Wilson a chance to replicate last week's career-high 80 yard performance, but he would see a decrease in targets should Alshon Jeffery return from a hamstring injury.
Took a backseat after leading the Washington backfield in snaps the week prior, but could emerge again in a possible high-scoring affair against the Falcons.
Brandon Myers will look for more targets (three last week) in Sunday's matchup against the forgiving Jags' secondary.
The New Orleans defense may be ripe for the picking, but Sturgis is an inaccurate kicker attached to a shaky offense.
Smtih and the San Francisco passing attack will look to take advantage of a New York Giants pass defense that has allowed a league-high 316.3 passing yards per game in Week 5.
Watkins may miss a second straight game with a calf strain, but he'll face a shaky defense if he's able to play.
Benjamin Watson continues to insert himself in the offense (3-30-0), but has yet to score a touchdown and faces an Eagles team on Sunday that’s yet to allow one to a tight end this season.
Darrius Heyward-Bey has been outplaying Markus Wheaton for the second wide receiver slot, but both may take a backseat to the recently-returned-from-suspension Martavis Bryant as soon as this week against a San Diego Chargers team that is tenth in the NFL with 225 passing yards allowed per game.
Stafford will look to become the second quarterback all season to top 200 yards against a Cardinals defense that ranks second in the league with seven interceptions.
Riddick is averaging five catches through four games, giving him some appeal for an offense that is averaging a mere 47.0 yards per game on the ground.
Ellington should be back from a knee injury but another strong game from running back Chris Johnson (16 carries, 83 yards against the Rams) clouds the Arizona ground game picture in a Week 5 matchup against the Lions.
Zach Hocker missed a crucial 30-yard field goal that could've won the game, but remains the Saints kicker on Sunday against the Redskins.
Back atop the Washington running back heap last week, but gained just 62 yards on 17 carries.
Austin may have a tough time repeating his Week 4 performance (six catches, 96 yards and two scores) against a Packers defense that has yielded just four passing touchdowns and under 200 yards passing per game this season.
Marcedes Lewis had his first receptions of the season in Week 4, but there may be fewer targets in Week 5 when the Jacksonville Jaguars face the Tampa Bay Buccaneers, who are susceptible to the run.
Marqise Lee is dealing with a hamstring injury that leaves him questionable entering a Week 5 matchup against the Tampa Bay Buccaneers.
Johnson turned 10 targets into four catches and his fourth TD of the season in a Week 4 loss but the expected return of running back Andre Ellington figures to slide him down the depth chart so he'll need to make the most of his limited touches against the Lions in Week 5.
Josh Lambo made good use of a second chance last week to boot his first career game-winner, but he may not get much of a chance to build on that confidence-booster Monday against a Steelers defense allowing just 18.8 points per game.
Charles Sims will hope to regain his role as the primary passing-down back for the Bucs in Sunday's matchup against the Jags after being beat out by Doug Martin for the most receptions out of the backfield last week (five-to-three).
Dorial Green-Beckham is on a roll, having caught touchdown passes in two straight games and looking to make it a third straight in Week 5 when the Tennessee Titans host the Buffalo Bills.
Has led the team with 25 carries the past two weeks, albeit for just 64 yards, and gets to face off a San Francisco 49ers defense allowing nearly 28 points a game.
Mychel Rivera has seen his role in the offense all but vanish due to the Raiders passing game being focused on Amari Cooper and Michael Crabtree, and Rivera isn't likely to improve his numbers Sunday against a Broncos defense that has yet to allow a touchdown to a tight end this season.