Brady brings a 370.7 yard per game average into a game against a 19th ranked Cowboys pass defense that has allowed 307.5 yards in their last two outings.
Manning has thrown multiple touchdown in three straight games, and now gets to feast against a poor 49ers pass defense.
Matt Ryan should keep rolling along after posting the highest yards per attempt and completion percentage of his season in Sunday's matchup against the Redskins.
Over 600 yards the past two games, and gets an Atlanta pass defense yielding 30 yards per game in what could be a shoot out.
Palmer and the Arizona passing attack should find plenty of room to operate against a Lions defense who were yielding 271.5 yards passing in the first four weeks of the season.
A healthier Drew Brees gets a good matchup against the Eagles that have allowed 276.5 passing yards per game this season.
Kaepernick will look to turn around his woeful season against the league's worst pass defense as the 49ers take on the Giants in Week 5.
Bradford will face a soft defense after last week's impressive second-half rally against the Redskins, but the Philadelphia offense still looks out of sync.
Marcus Mariota leads a feisty Tennessee Titans' offense against the Buffalo Bills, who rank 29th in passing yards allowed per game. Will Bills head coach Rex Ryan have a plan for the rookie?
Cutler made an early return from a hamstring injury last week, and while turnovers remain a problem, he'll face a Chiefs defense that is allowing 31.3 points and 296 yards passing per game.
Taylor has a favorable matchup in terms of the opponent, but his own team's injury concerns leave the offense on shaky footing.
Blake Bortles has shown improvement in his second year at the helm of the Jacksonville Jaguars' offense and enters Week 5 against a beatable Tampa Bay Buccaneers.
Peyton Manning posted a season-best 7.9 YPA in Week 4, and has a solid matchup Sunday against a Raiders defense allowing over 300 passing yards a game.
Rodgers faces a Rams defense that has allowed only three touchdown passes while racking up 17 sacks in four games, tempering expectations slightly in Week 5.
Wilson passed for a season-high 287 yards and a touchdown in a Week 4 win over the Lions and would look to take advantage of a Bengals defense that is allowing the sixth-most passing yards per game (279.0) in Week 5.
A damaged Andrew Luck (shoulder) will make his return in Week 5 against the Houston Texans.
Foles and the Rams passing attack will face another tough test on the road against the Packers as he looks to build off of last week's three touchdown performance.
Philip Rivers is on pace for nearly 5000 passing yards this season and may not slow down much Monday against a Steelers defense allowing a 100.4 QB rating despite giving up just 18.8 points per game.
Jameis Winston will look to bounce-back on Sunday from a four-interception Week 4 as he takes on the forgiving Jaguars secondary that's allowed 279 passing yards per game.
Alex Smith passed for a season-high 386 yards last week but couldn't get the ball into the end zone, and is likely to throw far less often Sunday against a Bears defense allowing 4.4 yards per carry and almost 120 rushing yards per game.
Houston Texans head coach Bill O'Brien is sticking with Ryan Mallett after pulling him from last week's lopsided loss. The season's on the line in Week 5 against the Indianapolis Colts, who rank 23rd in passing yards allowed per game.
Derek Carr's surprisingly good start to the season will be put to the test Sunday, on the road against a Broncos defense with a league-leading 18 sacks.
Stafford will look to become the second quarterback all season to top 200 yards against a Cardinals defense that ranks second in the league with seven interceptions.