Matthew Stafford faces a Packers defense against which he's thrown at least two touchdowns in three straight meetings, and one which has allowed 277 yards per game through two outings while missing top cornerback Sam Shields.
Ben Roethlisberger will have a Week 3 road matchup against the Eagles shaky secondary, after the veteran has thrown three touchdown passes in each of his first two games.
Andrew Luck needs to bring the Colts back from an 0-2 start in Week 3 against the San Diego Chargers, who are the league's 28th-ranked passing defense (324.5 ypg).
Carson Wentz will be throwing early and often against Pittsburgh's 31st-ranked pass defense in an attempt to keep up with the opposition's high-powered offense.
Joe Flacco will be on the road this Sunday to face the Jaguars, a team he threw for 316 yards with three touchdowns and two interceptions against in their 2015 meeting.
Matt Ryan will look to make it three 300-yard games in a row Monday night against the Saints, who allowed 368 yards to Eli Manning last week.
Philip Rivers didn't miss a beat last week despite the loss of Keenan Allen, and now faces a Colts defense Sunday that's allowed a league-worst 36.5 points per game so far.
Aaron Rodgers has posted two mediocre performances to open the year, but has a get-well opportunity Sunday against a Lions defense that has allowed 296 yards per game through the air and six touchdowns.
Carson Palmer's bevy of weapons make him a strong option Sunday against a Bills defense that just gave up 374 passing yards to Jets quarterback Ryan Fitzpatrick.
Eli Manning has three excellent weapons to throw to heading into Sunday's divisional matchup with a Redskins defense that's giving up 32.5 points per game.
Blake Bortles has posted two 300-yard passing games, but is coming off a three-turnover week as he prepares for a home game against the Ravens, who rank first in passing defense.
Drew Brees was under duress all game against the Giants but should find more time Monday against the Falcons, who hit Derek Carr just once last week.
Derek Carr has benefited from two early shootouts, but could have a quieter performance Sunday on the road against a Titans defense that's allowed just 20 points per game so far in 2016.
Ryan Tannehill faces a Cleveland Browns passing defense in Week 3 that has allowed 286 yards per game through the air.
Ryan Fitzpatrick exorcised his demons against Rex Ryan and on Sunday will face a Kansas City Chiefs defense allowing 243.5 yards per game through the air, which is 15th in the NFL.
Brock Osweiler brings his 3:3 TD:INT ratio on the road in Week 3 to New England, who have allowed 320.5 passing yards per game (28th) after two weeks.
Marcus Mariota is still getting used to new offensive weapons as the Titans prepare for a Week 3 home game against the Oakland Raiders, who rank last in passing defense (404.0 ypg).
Kirk Cousins doesn't protect the ball well, but he's worth the risk Sunday against a Giants team that gave up 298.9 passing yards per game last year.
Sam Bradford's debut with the Vikings couldn't have gone better, but a road contest against a Panthers defense that is allowing 198 yards per game and has four interceptions will pose a new challenge.
Brian Hoyer is in line to start in place of Jay Cutler, who injured his thumb in Week 2, against a Cowboys secondary that was just gashed for 364 yards by the Redskins' Kirk Cousins.
Case Keenum hasn't led the Rams to a touchdown in two games, so expect a Buccaneers defense that's allowing 318.5 passing yards per game to improve on that stat against him Sunday.
Dak Prescott will likely take a back seat to the running game against a stingy Bears secondary that has held opponents to 197.5 passing yards per game.
Andy Dalton will be on his home field on Sunday to face the Broncos and their shutdown defense that held both Andrew Luck and Cam Newton to fewer than 200 passing yards and one passing touchdown each.
Jameis Winston tossed four picks last week and was hit eight times by the Cardinals, and could face similar pressure this weekend as the Rams hit Russell Wilson nine times and held the Seahawks to just three points.
Russell Wilson may be without top wideout Doug Baldwin, which should knock him out of the QB1 discussion Sunday against San Francisco when paired with his limited mobility due to a lingering ankle injury.
Tyrod Taylor tossed three touchdown passes last week, but could face a stiffer test on Sunday against an Arizona Cardinals defense that has allowed just two throwing touchdowns thus far this season.
Cody Kessler will make his professional debut on Sunday at Miami to face a defense that gave up three touchdown passes to Jimmy Garropolo last week.
Cam Newton bounced back in a big way last week, throwing for four touchdowns and 353 yards (plus adding 37 more on the ground), but will face the tough Vikings defense Sunday that sacked Aaron Rodgers five times in Week 2.
Alex Smith wasn't able to repeat his big Week 1 numbers, but could provide solid value Sunday against a Jets defense that just got lit up by Bills' QB Tyrod Taylor.
Tom Brady will miss his third game due to suspension.
Jared Goff would have a decent matchup against the struggling Tampa Bay secondary, but the first overall pick is still serving as the backup to Case Keenum.
Trevor Siemian has just a 1:3 TD:INT through his first two NFL starts, and things won't get any easier Sunday on the road against a Bengals defense that finished fifth in QB rating allowed last season.
Jacoby Brissett will face a difficult task as a rookie starting his first game against a ferocious Houston Texans defense allowing just 179 passing yards per game to begin the 2016 campaign.
Jay Cutler is dealing with ligament damage in his right thumb, and is looking at a lengthy absence from the field should surgery be required.
Blaine Gabbert will find sledding tough in what projects to be a low-scoring game Sunday against a Seattle defense that's allowing just 184.5 passing yards per game.
Jimmy Garappolo will likely miss Thursday's game with the Houston Texans due to a shoulder injury.