Tom Brady, sure to be motivated by last year's Deflategate saga, faces an Indianapolis Colts defense that is 28th in the NFL in terms of passing yards allowed this season.
Palmer shouldn't have much trouble building on his early-season success in a matchup with the shaky Pittsburgh secondary.
Carves up Saints' defense for 333 yards and now faces a Giants' defense allowing a league-worst 304.2 passing yards per game.
Rodgers seems likely to bounce back from a three-turnover performance against a Chargers defense that allowed Browns' quarterback Josh McCown to throw for 356 yards and two scores two weeks ago.
Philip Rivers has a tough road matchup Sunday against a Packers defense allowing a 62.8 QB rating, second-best mark in the league, but he could still have a productive high-volume game if the Chargers fall behind Aaron Rodgers early.
Tyrod Taylor continues his surprise campaign against a Cincinnati Bengals defense allowing 263 passing yards per game, which is 22nd in the NFL.
Though the Bears rank fourth in the league in passing yards allowed, they have allowed 11 touchdowns while only taking two interceptions, giving Stafford a chance to jump-start his woeful season.
Peyton Manning struggled once again in Week 5, but could see an uptick in his performance Sunday against a Browns defense lacking a strong pass rush (16th in sacks) or an opportunistic secondary (just one INT on the season, last in the league).
Record-setting day against the 49ers, but receiving corp could be thinned with hamstring injuries to Odell Beckham and Rueben Randle.
Kaepernick bounced back from a nasty slump in Week 5, and he now gets to face a porous Baltimore pass defense. Given his early-season struggles, it's still far from a sure thing.
Cutler has topped 250 yards and thrown for two touchdowns in each game since returning from a hamstring injury, and faces a Lions defense that has only three interceptions on the year.
Marcus Mariota and the Tennessee Titans have a Week 6 match-up against the Miami Dolphins, who have allowed 25 points per game.
Blake Bortles is dealing with a sprained AC joint in his throwing shoulder, but is expected to play Week 6 against the Houston Texans, who have given up over 736 yards passing the last two games.
Bridgewater has an inviting matchup against the Chiefs 27th ranked pass defense that is allowing 285 yards weekly, but questions remain about how often Bridgewater will be asked to throw.
This may be the week the training wheels come off against the high-powered New England attack; it remains to be seen if there are enough weapons at his disposal though, especially with Lance Dunbar injured.
Ryan Tannehill will try to right the sinking ship Sunday against the top-ranked passing defense in the NFL in terms of yards allowed per game.
Six interception and five touchdowns on the year and now faces a rested Jets' defense allowing less than 14 points per game.
Alex Smith could be required to look downfield more with Jamaal Charles now out for the season, but Sunday's road game against a Vikings defense allowing just 6.7 yards per pass attempt will be a tough test if he uses a more aggressive game plan.
Michael Vick is still working to get on the same page with his receivers, but hopes to build on the momentum of leading two late touchdown drives to defeat the San Diego Chargers in his Week 6 outing against an Arizona Cardinals defense that leads the league with 11 interceptions through five games.
Ryan Fitzpatrick and the Jets face a surprisingly stingy Washington Redskins defense allowing just 216.4 yards per game through the air.