LeGarrette Blount has scored in all but one game this season, has three 100-yard rushing outputs to his name in 2016, and faces a Buffalo defense allowing 125 rushing yards per tilt, which is 27th in the NFL.
Ezekiel Elliott will be fresh off a bye and going for his fifth straight game over 130 rushing yards on Sunday Night Football against the Eagles.
Matt Forte broke out of a season-long slump last weekend and should take advantage of a questionable Cleveland Browns rushing defense allowing 139.9 yards per game on the ground in 2016.
Christine Michael has topped 50 yards every week, and that trend's unlikely to stop Sunday against the 23rd-ranked Saints run defense.
James White has three receiving touchdowns over the past two games, but faces a Buffalo defense that has yielded just four throwing scores in 2016, which is tied for first in the league.
Devonta Freeman will hope the Packers’ defense gives way like they did against Ezekiel Elliot (157 yards rushing) as opposed to the 166 they’ve given up to the other five teams they’ve played leading rusher combined.
Giovani Bernard will have a Week 8 tilt against Washington after touching the ball at least 15 times in each of his last three contests.
David Johnson has 82 carries for 381 yards over the past three weeks, and even Carolina's seventh-ranked run defense is unlikely to slow him down.
Jacquizz Rodgers may not reach 100-yards for his third-consecutive game whether or not Doug Martin returns, but will face a plus-matchup against the Raiders, who’ve allowed three 100-yard rushers this season.
Chris Thompson managed 113 yards on 19 touches last week, and should once again be involved out of the Redskins backfield Sunday against the Bengals.
Jeremy Hill will face a Washington defense in Week 8 that’s allowed six different running backs to score rushing touchdowns against them in 2016.
Frank Gore remains healthy as the Indianapolis Colts deal with injuries to other skill players entering Week 8 against the Kansas City Chiefs, who rank 22nd in rushing defense and 19th in passing yards per game allowed to running backs.
Mark Ingram likely won’t get the volume to have a big day on the ground against the Seahawks, who haven’t allowed more than 51 yards rushing to anyone with fewer than 20 carries—a mark Ingram’s yet to hit this season.
Matt Jones's fumbling issues have allowed Chris Thompson to start siphoning off more of his workload heading into Sunday's London game against the Bengals.
Mike Gillislee would be in line for an expanded role should LeSean McCoy miss Sunday's game due to a hamstring injury, though the New England Patriots are allowing just 92.3 yards per game on the ground, which is 11th in the NFL.
If he can go, Doug Martin will get a crack at the Raiders’ bottom-five run defense that’s allowed three 100-yard rushers this season.
Duke Johnson will take on the Jets this Sunday, as he’ll look to gain yardage as a receiver against the unit that’s allowed at least 27 receiving yards to four different running backs this season.
Tevin Coleman broke a 30-yard touchdown run last week, but his diminishing role as a regular part of the offense makes him a tough play against the Packers top-ranked defense against running backs.
With the Tennessee Titans having little prep time in Week 8 against the Jacksonville Jaguars on Thursday, Derrick Henry may be asked to share more of the backfield snaps with DeMarco Murray.
Jonathan Stewart will look for room to run against the Cardinals, who allowed Christine Michael to go for just 52 yards in 75 minutes and have allowed just four rushing touchdowns to opposing running backs this season.
Isaiah Crowell will have a Week 8 tilt against the Jets who have a defense that has held every running back they’ve faced, except David Johnson, to 75 or fewer rushing yards.
Reggie Bush scored a touchdown this past Sunday, but it was on his lone carry of the game, and Mike Gillislee would be the first in line to take over rushing duties if LeSean McCoy is hurt.
Bilal Powell took a backseat to Matt Forte last weekend, but could see additional touches if Sunday's game gets out of hand against the abysmal Cleveland Browns, whose defense is allowing a total of 425.6 yards per game, which is 31st in the NFL.
Ka'Deem Carey has outperformed Jordan Howard over the last two weeks, seemingly earning himself an equal role in the Bears' backfield, but faces a third-ranked Vikings rush defense on Monday that is allowing only 81.7 yards per game.
James Starks is likely to be sidelined three more weeks following knee surgery.
LeSean McCoy had to leave Sunday's game early due to a nagging hamstring injury, and his status remains uncertain heading into this weekend's clash with the New England Patriots.
Knile Davis is likely to see more than the two carries he had last week with more practice reps under his belt, but will play second fiddle to Ty Montgomery against an 11th ranked Falcons rush defense that is allowing only 91.9 yards per game on the ground.
Jordan Howard has only 56 yards on 22 carries over the last two weeks while Ka'Deem Carey has seen an increase in carries, and faces a Vikings defense that ranks third against the rush, allowing 81.7 yards per game.
Eddie Lacy has been placed on injured reserve following ankle surgery, and it's uncertain whether he'll return again this season.