DeAndre Hopkins will look to pad his stats in Week 12 when the Houston Texans air it out against the New Orleans Saints, who rank 30th pass defense (290.5 ypg).
Gary Barnidge got good news with the return of Josh McCown as the starting quarterback in Cleveland, as Barnidge averaged 85.3 yards and a touchdown per game while playing with McCown, and this week has a good match-up gainst a Baltimore Ravens pass defense that is 24th in the NFL with 257 passing yards allowed and that is tied for 23rd with 19 passing touchdowns allowed this season.
Odell Beckham enters the game against Washington with three-straight 100-yard games and 38 targets over the same three-game stretch.
Allen Robinson leads the Jacksonville Jaguars in receptions, yards and is tied in touchdowns entering a Week 12 matchup against the San Diego Chargers, who rank 17th in passing defense (247.5 ypg).
Palmer overcame some early turnovers and torched the Bengals for 317 yards and four touchdowns and will look to continue his recent hot streak against the 49ers in Week 12.
Josh Brown connected on all four field goal attempts and both extra points in the loss to New England, vaulting him to third overall in kicker scoring through the first 11 weeks.
Rawls ran over the 49ers for 255 yards of total offense and a pair of touchdowns in Week 11 but will have a hard time replicating those numbers against a Steelers defense that has allowed three rushing touchdowns all season as he handles the lead back duties with the injury to Marshawn Lynch.
Coming off a relative down week, Mike Evans should bounce back against a Colts secondary that’s allowed five 100-yard receivers this season.
DeSean found the end zone for the first time this year against Carolina among his eight targets and gets a nice matchup against a poor pass defense this week.
Catanzaro continues to enjoy kicking for a high octane offense and should be in for another big game against the 49ers in Week 12.
Calvin Johnson has at least 81 yards in five straight games and will face an Eagles defense Thursday that is allowing 246 yards per game and 20 receiving touchdowns, 14 of which have gone to opposing wide receivers.
Eli Manning now has two 300+ yard efforts in his last three games following a 361-yard effort against the Patriots back in Week 10.
DeAngelo Williams had a down game against the Cleveland Browns in Week 10 but had averaged 150 yards and 1.7 touchdowns in three starts previous to that one, and this week he faces a tough Seattle Seahawks run defense that allows only 96.4 yards per game on the ground.
Jordan Reed failed to find the end zone for the firs time in four weeks, but gets to take on a shaky New York Giants' pass defense provided Reed's minor knee injury doesn't keep him sidelined.
LeSean McCoy is averaging 102 yards per game over his last three contests, at a rate of 5.6 yards per tote, but clashes with a Kansas City Chiefs defense that is fourth in the NFL in rushing yards allowed this season.
Fitzgerald's TD pace has slowed but he's still averaging 13 targets over the last three weeks and could be in for another big game against the 49ers in Week 12.
Aaron Rodgers has eight touchdowns in his last three games, and faces a Bears defense which he has lit up for 13 scores in his last three games against
Johnson's found little room to run the last two weeks against a pair of stingy run defenses but his continued dominance of the workload out of the backfield should bear fruit against a leaky San Francisco run defense in Week 12.
Brandon Marshall continues to play through injury, but has scored in three-straight outings and had seven catches for 128 yards when the Jets faced the Dolphins earlier this season.
Stephen Gostkowski missed his first field goal of the season Monday, but remains the top scoring kicker in the NFL, and will still be valuable despite playing against a Denver Broncos squad allowing just 18.3 points per game.
Delanie Walker leads the Tennessee Titans in all the major receiving categories entering their Week 12 battle against the Oakland Raiders, who rank 30th in passing defense (290.5 ypg).
Doug Martin probably won’t get 235 rushing yards again this week, but does get a good matchup against the poor Colts run defense.
Chris Ivory has failed to rush for 100 yards in five-straight games, but faces a Miami Dolphins defense that has been gutted for 138.6 yards per game on the ground; Ivory ran for 166 yards and a touchdown in the first meeting between the two squads.
Eric Decker had a three-game scoring streak snapped this past weekend, but could get back into the end zone against a Miami Dolphin defense that has yielded 19 passing scores in 2015, which is tied for 23rd in the league.
Dez Bryant scored just his second touchdown of the season in the win over Miami, and finally gets to take the field again with a healthy Tony Romo.
Tyler Eifert caught two more touchdown passes in Week 11 against the Arizona Cardinals to build his NFL-leading receiving touchdown total up to 12, but this week faces a stiff challenge in a St. Louis Rams pass defense that has only allowed a league-best eight passing touchdowns all season.
Andy Dalton exploded for 315 passing yards and two touchdowns against the Arizona Cardinals on Sunday, and faces another tough test this week against a St. Louis Rams defense that allows 229.4 passing yards per game but has only given up eight touchdowns all season through the air.
Giovani Bernard showed off his explosive pass-catching ability in Week 11 that allowed him to produce 146 total yards against the Arizona Cardinals, which should help him this week he faces a St. Louis Rams defense that allows 108.1 yards per game on the ground but has only allowed six rushing touchdowns all season.
Josh McCown has been reinstated as the starting quarterback for the Cleveland Browns, just in time for a match-up with a poor Baltimore Ravens pass defense that he torched for 457 yards and two touchdowns back in Week 5.
T.J. Yeldon looks to end a three-game scoreless drought in Week 12 when the Jacksonville Jaguars face the league's 27th-ranked rushing defense, the San Diego Chargers, who rank 31st in rushing touchdowns allowed (12).
Matt Forte appears likely to return from a three-game absence due to a knee injury, and assuming he gets his full compliment of touches, will face a Packers defense which he gashed for 166 total yards and a score in Week 1.
Kamar Aiken led the Baltimore Ravens in receptions, targets, and scored the only touchdown on Tuesday but will have to establish chemistry with new quarterback Matt Schaub this week against a Cleveland Browns defense that is 26th in the NFL in passing yards allowed and 30th in passing touchdowns allowed.
Bailey was asked to make just one field goal in the win over Miami but should benefit from the improved offense now that Tony Romo is back.
Blake Bortles looks to lead the Jacksonville Jaguars to its third straight win in Week 12 when they face the San Diego Chargers, who rank 17th in pass defense (247.5 ypg).
Sammy Watkins has six catches for just 53 yards over his last two games, but faces a Kansas City passing defense that is in the middle of the pack in terms of passing yards and touchdowns surrendered this season.
Mason Crosby nailed five field goals last week after having just six attempts in his last five outings, and will face a Bears defense that is giving up 25.1 points weekly.
Larry Donnell missed his second straight game against New England but is expected back for the game against Washington and should resume his role as TE1.
Duke Johnson continues to be out-carried by Isaiah Crowell but his receiving ability allows him to be the more effective back for the Cleveland Browns, and while Week 12 opponent the Baltimore Ravens is solid against the run (97 yards, 0.6 rushing touchdowns per game) they are weaker in pass defense (24th in the NFL with 257 passing yards allowed per game), which is Johnson's specialty.
Greg Olsen had another strong game last week (3-54-1), but goes up against a Cowboys defense that’s allowed just two tight ends to break the 50-yard mark.
Adrian Peterson faces a Falcons rush defense that is a bit of an enigma, having allowed 11 rushing touchdowns, the third most in the league, but a league-low 87.4 yards per game through 10 contests.
Floyd was absent in Week 11 due to a hamstring injury but will look to restart his four-game TD streak if he can get back into the lineup in Week 12 against San Francisco.
Kai Forbath is just 1-for-2 on field goal attempts in four games with the Saints this season.
James Jones had more catches and yards last Sunday than he did in his last four weeks combined, and faces a Bears defense that he scored twice against on four catches in Week 1.
Brandin Cooks is coming off his best game of the season (5-98-2), but goes up against a Texans defense that’s shut down A.J. Green and Brandon Marshall in back-to-back weeks.
Marquess Wilson could function as the team's second receiver Thursday against the Packers with Eddie Royal and tight end Martellus Bennett both dealing with injuries, giving him a chance to build on last week's 102 yard performance.
Matt Prater has five made field goals in his last two games after connecting on only eight through the first eight games and will face an Eagles defense that has allowed at least nine points to four straight opposing kickers.
With three touchdowns the last two weeks, Ahmad Bradshaw is getting more involved in the offense and that should continue in Week 12 when the Indianapolis Colts host the Tampa Bay Buccaneers, who rank 13th in overall defense (339.1 total ypg).
Brent Celek racked up a season-high 79 yards on a team-leading 10 targets and could see similar volume against Detroit if Zach Ertz remains sidelined.
Jonathan Stewart has been incredibly steady all season, but the Cowboys have allowed only one 100-yard rusher, despite allowing the fourth most fantasy points to opposing running backs.
Hauschka has a reliable floor with multiple field goals in four of his last five games and will look to post a double-digit total for the first time since Week 7 as Seattle hosts the Steelers in Week 12.