Clay has emerged as Tyrod Taylor's favorite target, and the Bills may have to rely on their passing attack if both LeSean McCoy (hamstring) and Karlos Williams (concussion) are out.
Julio Jones may have fallen way off his season-long pace last week (4-38-0), but that doesn't mean he's not still the best receiver in football and should show that Sunday against the Redskins.
Gurley exploded in the second half on the way to 146 yards rushing against the Cardinals in Week 4 and figures to see a heavy workload against a Packers defense that is yielding 115.0 rushing yards per game and 4.8 YPC (third worst in the league) in Week 5.
Graham became the first tight end not to score against the Lions in a Week 4 win but he'll look to get back on track against an exploitable Bengals secondary (279.0 passing yards allowed per game) in Week 5.
Averaging 10 catches on 14 targets through three games, Edelman should be in for another heavy dose of looks against a Cowboys defense that has allowed 307.5 yards per game in their last two outings.
Dixon isn't going to break off many long gains, but he could be in for a heavy Week 5 workload against a questionable defense, as teammates LeSean McCoy (hamstring) and Karlos Williams (concussion) are both in danger of missing the game.
Lacy is coming off of a season-high 90 yards and faces a Rams defense that is allowing the seventh most rushing yards per game at 120.3.
Leonard Hankerson, now the No. 2 receiver on the high-octane Falcons offense, should have another good week against the Redskins after his first 100-yard receiving day since 2011.
Just 38 yards on five catches, but 12 more targets, and gets to square off a yielding 49ers' defense.
Forte is averaging 24.3 touches through four games and faces a Chiefs defense that has allowed at least 31 points in three straight games.
Matthews has been quiet the past two weeks, but he's easily the safest part of Philadelphia's shaky offense, and he'll face a porous New Orleans secondary in Week 5.
The Cowboys defense has not allowed an opposing tight end to score or catch more than three passes, something that figures to change once Gronkowski and the Patriots leave town in Week 5.
T.J. Yeldon is coming off the first 100-yard game of his career and may get a second in Week 5 against the Tampa Bay Buccaneers, the NFL's 30th-ranked rushing defense.
Fitzgerald should have no problem continuing his hot start to the season in a Week 5 matchup against a Lions defense that is yielding 271.5 passing yards per game.
Kendall Wright has benefited form better quarterback play this season and will face the league's 29th-ranked passing defense in Week 5 when the Buffalo Bills visit Nashville.
The Houston Texans' game plan in Week 5 against the Indianapolis Colts will be to run the ball, and that means Arian Foster.
Lewis is averaging 15 touches per game despite the return of LeGarrette Blount, and facing a Cowboys defense that has allowed at least four catches to opposing running backs in every game this season bodes well for continued opportunities.
Brown will continue to have to fight for targets in the Arizona passing attack but a Week 5 matchup against the Detroit Loins should give him chances to make an impact.
Donte Moncrief leads the Indianapolis Colts in touchdowns as the prepare for a Week 5 game against the Houston Texans.
Marques Colston will look to get more than the fifth-most targets on the team in Sunday's matchup against the poor Eagles secondary.
While he may not catch 80-yard touchdown passes every week, C.J. Spiller gets a good matchup in PPR leagues against an Eagles team that's allowed more than 50 receiving yards to running backs per game.
Coming off of a season-high 11 catches and 83 yards, Bennett faces a Chiefs pass defense that has allowed a league-high 11 touchdown passes to date, though none have gone to tight ends.
Allen Hurns has been a more consistent receiver in his second season with the Jacksonville Jaguars and he'll remain the number two target in Week 5 against the Tampa Bay Buccaneers.
Baldwin gets a favorable draw against a Bengals defense that has allowed the sixth-most passing yards per game (279.0) through the first four weeks of the season in a Week 5.
Johnson turned in a solid performance against the Rams in Week 4 (16 carries, 83 yards) but his value going forward will depend on his ability to keep his starting role with the return of Andre Ellington.
Could benefit from the injury to tight end Jordan Reed on an offense that has thrown the ball 94 times the past two weeks.
Royal's upside will tie directly to the availability of Alshon Jeffery, but facing a Chiefs defense that allows 296 yards and 31.3 points per game, there should be enough to go around for Royal.
With 18 targets the past two weeks, Crowder makes for a sneaky play with a good matchup if DeSean Jackson remains sidelined this week.
With so many of his teammates hobbled by injuries, Harvin could see some extra targets against a shaky Tennessee secondary.
Devonta Freeman may not get three rushing touchdowns for the third-straight week, but has cracked tougher defensive nuts than the Redskins, who've allowed just one rushing touchdown this season.
Owen Daniels has an excellent chance of extending his touchdown streak to three games Sunday against a Raiders defense that's already allowed six tight end TDs in just four games.
The injury to Daniel Fells opens the door for a more expanded role.
Lynch showed improvement as the week progressed but was ultimately held out of action in Week 4 and will have a stern test against the Bengals (85.8 rushing yards allowed per game) if he's able to return for Week 5.
Delanie Walker will be three weeks removed from a wrist injury in Week 5 when the Tennessee Titans host the Buffalo Bills, who have allowed the third most receptions to opposing tight ends.
Scored for the second straight week and spends another week as WR2 with the injury setback to Victor Cruz.
Nate Washington is day-to-day with a hamstring injury leading up to Week 5, a Thursday night game against the Indianapolis Colts.
Cobb's volume remains high, averaging 10 targets over the past three games, but faces a sound Rams defense in Week 5 that has allowed only one touchdown to a wide receiver all season.
Frank Gore has yet to carry the Indianapolis Colts in any game, but that could change against the Houston Texans in Week 5 when quarterback Andrew Luck is still dealing with a shoulder injury.
Boldin might have his best chance at turning around a disappointing start with a Week 5 game matchup against the Giants' league-worst (316.3 yards per game) pass defense.
Heath Miller was held to a single reception for one yard in his first game with Michael Vick calling signals, and will have a chance to bounce back after an extra-long week of practice against a San Diego Chargers defense that is 25th in passing touchdown percentage allowed.
Vincent Jackson will look to build off his huge week (10-147-1) in Sunday's matchup against the middling Jaguars.
Williams struggled in his first start and is now dealing with a concussion, but the matchup is more than manageable, if he plays and LeSean McCoy (hamstring) doesn't.
Blount's yardage potential is apparently capped by the presence of Dion Lewis as a receiving threat, but facing a Cowboys defense that has allowed at least one rushing touchdown in three of four games and could be without linebacker Sean Lee sets Blount up for success in Week 5.
Murray should have some holes to run through against a soft New Orleans defense, but the entire Philadelphia offense still looks very shaky.
Should Jeffery return from a hamstring injury, he'll face a Chiefs defense that has eight opposing receivers top 80 yards in four games while allowing 11 touchdowns.
Brandin Cooks will look to convert more of his targets into receptions (4-of-8) as the Saints take on the Eagles' poor secondary (284.8 receiving yards per game) on Sunday.
Allen Robinson leads the NFL with 22 receiving yards per catch entering a Week 5 matchup against the Tampa Bay Buccaneers.
Coby Fleener is moving ahead of Dwayne Allen as a target as the Indianapolis Colts enter a Week 5 meeting against the Houston Texans.
Mike Evans was out-targeted by Vincent Jackson 15-to-8 and will hope to get on the right side of that balance against the middle-of-the-pack Jaguars secondary.
Davis was held out of Week 4 with a knee strain but could take advantage of a Giants defense that is yielding a league-high 316.3 passing yards per game if he's able to return in Week 5.