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Dixon isn't going to break off many long gains, but he could be in for a heavy Week 5 workload against a questionable defense, as teammates LeSean McCoy (hamstring) and Karlos Williams (concussion) are both in danger of missing the game.
Johnson turned in a solid performance against the Rams in Week 4 (16 carries, 83 yards) but his value going forward will depend on his ability to keep his starting role with the return of Andre Ellington.
Charles Sims will hope to regain his role as the primary passing-down back for the Bucs in Sunday's matchup against the Jags after being beat out by Doug Martin for the most receptions out of the backfield last week (five-to-three).
Bush could see a higher percentage of the snaps if San Francisco is forced into passing situations and will look to take advantage of the league's worst pass defense (316.3 yards per game) when the opportunity arises.
Johnson turned 10 targets into four catches and his fourth TD of the season in a Week 4 loss but the expected return of running back Andre Ellington figures to slide him down the depth chart so he'll need to make the most of his limited touches against the Lions in Week 5.