Allen Robinson leads the Jacksonville Jaguars in receptions, yards and is tied in touchdowns entering a Week 12 matchup against the San Diego Chargers, who rank 17th in passing defense (247.5 ypg).
Odell Beckham enters the game against Washington with three-straight 100-yard games and 38 targets over the same three-game stretch.
DeAndre Hopkins will look to pad his stats in Week 12 when the Houston Texans air it out against the New Orleans Saints, who rank 30th pass defense (290.5 ypg).
Calvin Johnson has at least 81 yards in five straight games and will face an Eagles defense Thursday that is allowing 246 yards per game and 20 receiving touchdowns, 14 of which have gone to opposing wide receivers.
Brandon Marshall continues to play through injury, but has scored in three-straight outings and had seven catches for 128 yards when the Jets faced the Dolphins earlier this season.
DeSean found the end zone for the first time this year against Carolina among his eight targets and gets a nice matchup against a poor pass defense this week.
Coming off a relative down week, Mike Evans should bounce back against a Colts secondary that’s allowed five 100-yard receivers this season.
Dez Bryant scored just his second touchdown of the season in the win over Miami, and finally gets to take the field again with a healthy Tony Romo.
Eric Decker had a three-game scoring streak snapped this past weekend, but could get back into the end zone against a Miami Dolphin defense that has yielded 19 passing scores in 2015, which is tied for 23rd in the league.
Fitzgerald's TD pace has slowed but he's still averaging 13 targets over the last three weeks and could be in for another big game against the 49ers in Week 12.
Golden Tate tied a season-high with eight catches last week and now faces an Eagles defense that has twice allowed a pair of opposing receivers to top 100 yards and has given up six touchdowns to receivers in their last three games.
Brandon LaFell has been targeted at least six times in five-straight games, and should continue to see plenty of looks due to the injuries to Julian Edelman and Danny Amendola.
Baldwin continues to hold some value in PPR formats by leading the Seattle passing attack but will need to shake off a low-ankle sprain as Seattle hosts the Steelers in Week 12.
Danny Amendola was targeted 12 times in the absence of Julian Edelman, but left New England's last game with a sprained knee, though he is not expected to miss Sunday's tilt with the Broncos.
Cecil Shorts is healthy again after missing a couple of games with a hamstring injury and Week 12 could be a good one for the Houston Texans' receivers against the New Orleans Saints, who rank 30th in pass defense (290.5 ypg).
Randall Cobb is on pace for only 885 yards but has seen at least nine targets in four straight games while scoring in two, and faces a Bears defense that has allowed 19 receiving touchdowns to date, including one to Cobb in Week 1.
A.J. Green caught four passes for 79 yards in Week 11, still with only one touchdown or 100-yard game since Week 3, and this week has a challenging match-up against a St. Louis Rams pass defense that allows 229.4 yards per game but has only given up eight touchdowns through the air all season.
Julio Jones could go up against Ronnie Lott in his prime and still put up good numbers, but will have his work cut out for him against a tough Vikings secondary.
Kamar Aiken led the Baltimore Ravens in receptions, targets, and scored the only touchdown on Tuesday but will have to establish chemistry with new quarterback Matt Schaub this week against a Cleveland Browns defense that is 26th in the NFL in passing yards allowed and 30th in passing touchdowns allowed.
Antonio Brown re-connected with Ben Roethlisberger in Week 10 to predictably huge results, but this week faces a tough test against a Seattle Seahawks defense that is second in the NFL with only 207.2 yards allowed through the air per game.
Alshon Jeffery could return to action Thursday after missing last week's game due to a groin injury, and would face a Packers defense that has allowed only three opposing receivers to top 100 yards to date.
Brown was limited by a hamstring but still managed three catches and a touchdown in Week 11 and could see a heavier workload if wideout Michael Floyd is unable to go again in Week 12 against San Francisco.
Donte Moncrief, who's scored a team-high five touchdowns in 2015, looks to snap a three-week scoreless drought in Week 12 when the Indianapolis Colts host the Tampa Bay Buccaneers, who are 30th with 21 passing touchdowns allowed.
Martavis Bryant exploded for 178 yards and a touchdown in his last outing against the Cleveland Browns, but this week has a much tougher test against the Seattle Seahawks and their Legion of Boom secondary, a unit that is second in the NFL with only 207.2 yards per game allowed through the air.
Allen Hurns is dealing with foot and abdomen injuries as the Jacksonville Jaguars prepare for a Week 12 game against the San Diego Chargers, who rank 17th in passing defense (247.5 ypg).
J.J. Nelson parlayed a hamstring injury to wideout Michael Floyd into an increased role in Week 11 and will look to build off that effort (four catches, 142 yards and a touchdown) if Floyd is unavailable again in Week 12 against San Francisco.
Sammy Watkins has six catches for just 53 yards over his last two games, but faces a Kansas City passing defense that is in the middle of the pack in terms of passing yards and touchdowns surrendered this season.
Marquess Wilson could function as the team's second receiver Thursday against the Packers with Eddie Royal and tight end Martellus Bennett both dealing with injuries, giving him a chance to build on last week's 102 yard performance.
Kendall Wright, who has missed the Tennessee Titans' previous three straight due to a knee injury, is expected to play in Week 12 against the 30th-ranked passing defense, the Oakland Raiders, who give up 290.5 passing yards per week.
T.Y. Hilton, who has just eight catches the last three weeks, looks to get back to his normal product in Week 12 when the Indianapolis Colts face the Tampa Bay Buccaneers, who rank 30th in passing touchdowns allowed (21).
Travis Benjamin has had mixed success with Josh McCown under center, but they did connect for six receptions and 83 yards in Week 5 against their Week 12 opponent the Baltimore Ravens, a weaker unit that is 24th in the NFL with 257 passing yards allowed and that is tied for 23rd with 19 passing touchdowns allowed this season.
Terrance Williams re-emerged to a state of fantasy relevance with the return of Tony Romo with a team-high 79 yards on four catches in the win over Miami.
Floyd was absent in Week 11 due to a hamstring injury but will look to restart his four-game TD streak if he can get back into the lineup in Week 12 against San Francisco.
Brandin Cooks is coming off his best game of the season (5-98-2), but goes up against a Texans defense that’s shut down A.J. Green and Brandon Marshall in back-to-back weeks.
James Jones had more catches and yards last Sunday than he did in his last four weeks combined, and faces a Bears defense that he scored twice against on four catches in Week 1.
Vincent Jackson made his triumphant return and should be a good play against the Colts forgiving secondary.
Boldin's topped 90 yards receiving in three of his last four games as he works around a nagging hamstring injury but may need to rack up some garbage time numbers in a tough Week 12 matchup against the Arizona Cardinals.
Nate Washington has just four catches for 45 yards the last two weeks, but his fortunes could change in Week 12 when the Houston Texans face the league's 30th-ranked pass defense in the New Orleans Saints.
Jarvis Landry had four catches last week, and he will likely draw the coverage of Darrelle Revis this weekend; Revis held Landry to four catches for 40 yards when the Dolphins faced the Jets earlier this season.
Fourteen of Griff Whalen's 18 targets have come in the last three games heading into the Indianapolis Colts' Week 12 game against the Tampa Bay Buccaneers, who rank 13th in passing defense (234.6 ypg).
Marques Colston has been relegated down the depth chart and has more than 50 receiving yards just twice in nine games this season.
Josh Huff hauled in his third touchdown of the season against Tampa Bay, though he was targeted just one time after 21 targets the prior five games.
Quietly, Jerricho Cotchery has established himself as a dependable option of the outside for Cam Newton and the undefeated Panthers, pulling in four receptions for 57 yards last week.
With Kendall Wright (knee) expected to return, Harry Douglas' opportunities will diminish in Week 12 when the Tennessee Titans host the Oakland Raiders, who rank 30th in pass defense (290.5 ypg) and 27th in scoring defense (25.9 ppg).
Pierre Garcon's streak of being held to 70 yards or under reached nine games in the loss to Carolina.
Davante Adams saw only four targets a week after he drew 21 looks while appearing to tweak his previously injured left ankle, making him a risky option on a short week against a Bears defense that is giving up only 217 yards per game through the air.
Jamison Crowder was held to a season-low one catch on just one target against Carolina after seeing 47 targets the prior six weeks.
Chris Harper could see some action due to the injuries to Julian Edelman, Danny Amendola and Aaron Dobson.
Stefon Diggs is looking for his first touchdown in four games against a Falcons secondary that has allowed just three opposing receivers to score to date.
Another quiet week from Rueben Randle, who is being out-paced in targets in recent weeks by Dwayne Harris.