Odell Beckham enters the game against Washington with three-straight 100-yard games and 38 targets over the same three-game stretch.
Allen Robinson leads the Jacksonville Jaguars in receptions, yards and is tied in touchdowns entering a Week 12 matchup against the San Diego Chargers, who rank 17th in passing defense (247.5 ypg).
DeAndre Hopkins will look to pad his stats in Week 12 when the Houston Texans air it out against the New Orleans Saints, who rank 30th pass defense (290.5 ypg).
Johnson's found little room to run the last two weeks against a pair of stingy run defenses but his continued dominance of the workload out of the backfield should bear fruit against a leaky San Francisco run defense in Week 12.
Brandon Marshall continues to play through injury, but has scored in three-straight outings and had seven catches for 128 yards when the Jets faced the Dolphins earlier this season.
Calvin Johnson has at least 81 yards in five straight games and will face an Eagles defense Thursday that is allowing 246 yards per game and 20 receiving touchdowns, 14 of which have gone to opposing wide receivers.
Doug Martin probably won’t get 235 rushing yards again this week, but does get a good matchup against the poor Colts run defense.
DeSean found the end zone for the first time this year against Carolina among his eight targets and gets a nice matchup against a poor pass defense this week.
Rawls ran over the 49ers for 255 yards of total offense and a pair of touchdowns in Week 11 but will have a hard time replicating those numbers against a Steelers defense that has allowed three rushing touchdowns all season as he handles the lead back duties with the injury to Marshawn Lynch.
Giovani Bernard showed off his explosive pass-catching ability in Week 11 that allowed him to produce 146 total yards against the Arizona Cardinals, which should help him this week he faces a St. Louis Rams defense that allows 108.1 yards per game on the ground but has only allowed six rushing touchdowns all season.
Dez Bryant scored just his second touchdown of the season in the win over Miami, and finally gets to take the field again with a healthy Tony Romo.
Eric Decker had a three-game scoring streak snapped this past weekend, but could get back into the end zone against a Miami Dolphin defense that has yielded 19 passing scores in 2015, which is tied for 23rd in the league.
LeSean McCoy is averaging 102 yards per game over his last three contests, at a rate of 5.6 yards per tote, but clashes with a Kansas City Chiefs defense that is fourth in the NFL in rushing yards allowed this season.
DeAngelo Williams had a down game against the Cleveland Browns in Week 10 but had averaged 150 yards and 1.7 touchdowns in three starts previous to that one, and this week he faces a tough Seattle Seahawks run defense that allows only 96.4 yards per game on the ground.
Michael Crabtree is on pace for a career season, and has an exploitable matchup Sunday against a Titans defense allowing 8.0 yards per pass attempt, fifth-worst in the league.
Chris Ivory has failed to rush for 100 yards in five-straight games, but faces a Miami Dolphins defense that has been gutted for 138.6 yards per game on the ground; Ivory ran for 166 yards and a touchdown in the first meeting between the two squads.
Coming off a relative down week, Mike Evans should bounce back against a Colts secondary that’s allowed five 100-yard receivers this season.
Fitzgerald's TD pace has slowed but he's still averaging 13 targets over the last three weeks and could be in for another big game against the 49ers in Week 12.
Antonio Andrews has averaged 58 yards rushing per game and had a favorable Week 12 matchup against the Oakland Raiders, who rank 23rd in rushing defense (114.7 ypg).
Steve Johnson remains Philip Rivers' most experienced healthy receiver, and could continue to see a high target volume Sunday against a Jaguars defense that ranks 25th in passing yards allowed.
T.J. Yeldon looks to end a three-game scoreless drought in Week 12 when the Jacksonville Jaguars face the league's 27th-ranked rushing defense, the San Diego Chargers, who rank 31st in rushing touchdowns allowed (12).
Antonio Brown re-connected with Ben Roethlisberger in Week 10 to predictably huge results, but this week faces a tough test against a Seattle Seahawks defense that is second in the NFL with only 207.2 yards allowed through the air per game.
Danny Amendola was targeted 12 times in the absence of Julian Edelman, but left New England's last game with a sprained knee, though he is not expected to miss Sunday's tilt with the Broncos.
Travis Benjamin has had mixed success with Josh McCown under center, but they did connect for six receptions and 83 yards in Week 5 against their Week 12 opponent the Baltimore Ravens, a weaker unit that is 24th in the NFL with 257 passing yards allowed and that is tied for 23rd with 19 passing touchdowns allowed this season.
Marquess Wilson could function as the team's second receiver Thursday against the Packers with Eddie Royal and tight end Martellus Bennett both dealing with injuries, giving him a chance to build on last week's 102 yard performance.
Matt Forte appears likely to return from a three-game absence due to a knee injury, and assuming he gets his full compliment of touches, will face a Packers defense which he gashed for 166 total yards and a score in Week 1.
Ronnie Hillman is coming off his third 100-yard rushing game of the season, but isn't likely to have as much success Sunday against the Patriots defense that's allowed just 88.8 rushing yards a game, second in the league.
T.Y. Hilton, who has just eight catches the last three weeks, looks to get back to his normal product in Week 12 when the Indianapolis Colts face the Tampa Bay Buccaneers, who rank 30th in passing touchdowns allowed (21).
Amari Cooper has the worst game of his career in Week 11, but will look to rebound Sunday against a Titans defense that's allowed 8.0 yards per pass attempt this season, fifth-worst in the league.
Gurley hasn't been able to break off one of his signature long runs in any of his last three games as opposing defenses continue to stack the box against him and will have a hard time extending his five-week scoring streak against a Bengals team that has yielded just three rushing scores all season in Week 12.
DeMarco Murray carried the ball just 13 times in a blowout loss to the Buccaneers but should see a bump against Detroit with Ryan Mathews expected to remain sidelined with a concussion.
Spencer Ware had a career game last week after Charcandrick West was injured and, if West's hamstring keeps him sidelined Sunday, would be in line for a start against a Bills defense more vulnerable against the run than the pass.
Baldwin continues to hold some value in PPR formats by leading the Seattle passing attack but will need to shake off a low-ankle sprain as Seattle hosts the Steelers in Week 12.
Javorius Allen has taken over the running back responsibilities for the Baltimore Ravens with Justin Forsett done for the season, and this week he has an excellent match-up against a Cleveland Browns defense that is dead last in the NFL with 138.8 rushing yards allowed per game.
Allen Hurns is dealing with foot and abdomen injuries as the Jacksonville Jaguars prepare for a Week 12 game against the San Diego Chargers, who rank 17th in passing defense (247.5 ypg).
Demaryius Thomas caught just his second TD pass of the season last week, and may not see his usual volume of targets Sunday against a Broncos defense that's allowing a league-low 18.2 points per game.
Danny Woodhead saw just two targets in last week's loss, but should see a much higher volume Sunday against a Jaguars defense that's had difficulty containing pass-catching backs and ranks 25th in passing yards allowed.
Eddie Lacy looked healthy and rejuvenated in a season-high performance last Sunday and will now face a Bears defense which allowed him to go for 85 yards and a touchdown in a Week 1 matchup.
Golden Tate tied a season-high with eight catches last week and now faces an Eagles defense that has twice allowed a pair of opposing receivers to top 100 yards and has given up six touchdowns to receivers in their last three games.
Brandon LaFell has been targeted at least six times in five-straight games, and should continue to see plenty of looks due to the injuries to Julian Edelman and Danny Amendola.
Latavius Murray hasn't topped 100 yards from scrimmage in three games, but faces a Titans defense Sunday that's allowed 110.1 rushing yards a game and nine rushing TDs, ranking in the bottom half of the league in both categories.
J.J. Nelson parlayed a hamstring injury to wideout Michael Floyd into an increased role in Week 11 and will look to build off that effort (four catches, 142 yards and a touchdown) if Floyd is unavailable again in Week 12 against San Francisco.
Cecil Shorts is healthy again after missing a couple of games with a hamstring injury and Week 12 could be a good one for the Houston Texans' receivers against the New Orleans Saints, who rank 30th in pass defense (290.5 ypg).
Duke Johnson continues to be out-carried by Isaiah Crowell but his receiving ability allows him to be the more effective back for the Cleveland Browns, and while Week 12 opponent the Baltimore Ravens is solid against the run (97 yards, 0.6 rushing touchdowns per game) they are weaker in pass defense (24th in the NFL with 257 passing yards allowed per game), which is Johnson's specialty.
Boldin's topped 90 yards receiving in three of his last four games as he works around a nagging hamstring injury but may need to rack up some garbage time numbers in a tough Week 12 matchup against the Arizona Cardinals.
Sammy Watkins has six catches for just 53 yards over his last two games, but faces a Kansas City passing defense that is in the middle of the pack in terms of passing yards and touchdowns surrendered this season.
Lamar Miller had a five-game scoring streak snapped last weekend, and faces a New York Jets defense that has allowed a league-best two rushing touchdowns in 2015.
Darren Sproles scored just his second touchdown of the year against Tampa Bay and could see a slight uptick in usage again this week with Ryan Mathews expected to remain sidelined.
Martavis Bryant exploded for 178 yards and a touchdown in his last outing against the Cleveland Browns, but this week has a much tougher test against the Seattle Seahawks and their Legion of Boom secondary, a unit that is second in the NFL with only 207.2 yards per game allowed through the air.
Jeremy Hill had a huge bounce-back effort in Week 12 with 45 rushing yards and two touchdowns, but this week faces a tough test in a St. Louis Rams defense that allows 108.1 yards per game on the ground but has only allowed six rushing touchdowns all season.