LeSean McCoy is averaging 102 yards per game over his last three contests, at a rate of 5.6 yards per tote, but clashes with a Kansas City Chiefs defense that is fourth in the NFL in rushing yards allowed this season.
Chris Ivory has failed to rush for 100 yards in five-straight games, but faces a Miami Dolphins defense that has been gutted for 138.6 yards per game on the ground; Ivory ran for 166 yards and a touchdown in the first meeting between the two squads.
Rawls ran over the 49ers for 255 yards of total offense and a pair of touchdowns in Week 11 but will have a hard time replicating those numbers against a Steelers defense that has allowed three rushing touchdowns all season as he handles the lead back duties with the injury to Marshawn Lynch.
Giovani Bernard showed off his explosive pass-catching ability in Week 11 that allowed him to produce 146 total yards against the Arizona Cardinals, which should help him this week he faces a St. Louis Rams defense that allows 108.1 yards per game on the ground but has only allowed six rushing touchdowns all season.
Johnson's found little room to run the last two weeks against a pair of stingy run defenses but his continued dominance of the workload out of the backfield should bear fruit against a leaky San Francisco run defense in Week 12.
Doug Martin probably won’t get 235 rushing yards again this week, but does get a good matchup against the poor Colts run defense.
DeAngelo Williams had a down game against the Cleveland Browns in Week 10 but had averaged 150 yards and 1.7 touchdowns in three starts previous to that one, and this week he faces a tough Seattle Seahawks run defense that allows only 96.4 yards per game on the ground.
Frank Gore suffered a minor knee injury last week and you'll need to see his level of participation in practice before starting him in Week 12 when the Indianapolis Colts face the Tampa Bay Buccaneers, who rank 14th in rush defense (104.5 ypg).
DeMarco Murray carried the ball just 13 times in a blowout loss to the Buccaneers but should see a bump against Detroit with Ryan Mathews expected to remain sidelined with a concussion.
Gurley hasn't been able to break off one of his signature long runs in any of his last three games as opposing defenses continue to stack the box against him and will have a hard time extending his five-week scoring streak against a Bengals team that has yielded just three rushing scores all season in Week 12.
Duke Johnson continues to be out-carried by Isaiah Crowell but his receiving ability allows him to be the more effective back for the Cleveland Browns, and while Week 12 opponent the Baltimore Ravens is solid against the run (97 yards, 0.6 rushing touchdowns per game) they are weaker in pass defense (24th in the NFL with 257 passing yards allowed per game), which is Johnson's specialty.
Jeremy Hill had a huge bounce-back effort in Week 12 with 45 rushing yards and two touchdowns, but this week faces a tough test in a St. Louis Rams defense that allows 108.1 yards per game on the ground but has only allowed six rushing touchdowns all season.
Javorius Allen has taken over the running back responsibilities for the Baltimore Ravens with Justin Forsett done for the season, and this week he has an excellent match-up against a Cleveland Browns defense that is dead last in the NFL with 138.8 rushing yards allowed per game.
Eddie Lacy looked healthy and rejuvenated in a season-high performance last Sunday and will now face a Bears defense which allowed him to go for 85 yards and a touchdown in a Week 1 matchup.
Lamar Miller had a five-game scoring streak snapped last weekend, and faces a New York Jets defense that has allowed a league-best two rushing touchdowns in 2015.
Matt Forte appears likely to return from a three-game absence due to a knee injury, and assuming he gets his full compliment of touches, will face a Packers defense which he gashed for 166 total yards and a score in Week 1.
Antonio Andrews has averaged 58 yards rushing per game and had a favorable Week 12 matchup against the Oakland Raiders, who rank 23rd in rushing defense (114.7 ypg).
T.J. Yeldon looks to end a three-game scoreless drought in Week 12 when the Jacksonville Jaguars face the league's 27th-ranked rushing defense, the San Diego Chargers, who rank 31st in rushing touchdowns allowed (12).
With three touchdowns the last two weeks, Ahmad Bradshaw is getting more involved in the offense and that should continue in Week 12 when the Indianapolis Colts host the Tampa Bay Buccaneers, who rank 13th in overall defense (339.1 total ypg).
Darren Sproles scored just his second touchdown of the year against Tampa Bay and could see a slight uptick in usage again this week with Ryan Mathews expected to remain sidelined.
Adrian Peterson faces a Falcons rush defense that is a bit of an enigma, having allowed 11 rushing touchdowns, the third most in the league, but a league-low 87.4 yards per game through 10 contests.
Darren McFadden ran for 129 yards in the win over Miami, but will face a far tougher test against a solid Carolina run defense.
Jonathan Stewart has been incredibly steady all season, but the Cowboys have allowed only one 100-yard rusher, despite allowing the fourth most fantasy points to opposing running backs.
Karlos Williams did not find the end zone in a game for the first time in his career Monday against New England, and faces a Kansas City Chiefs defense that has allowed just five rushing touchdowns in 2015, which is tied for sixth in the NFL.
David Cobb, who is back from a calf injury that forced him to miss the Tennessee Titans' first nine games, will get increased snaps in Week 12 against the Oakland Raiders, but is not yet ready for a big role and will continue to back up Antonio Andrews.
Isaiah Croweell had negative one total yards on seven touches in Week 10 against the Pittsburgh Steelers, but will try to bounce back in Week 12 against a Baltimore Ravens run defense that allows 97 yards per game on the ground.
Bilal Powell proved an extremely capable receiver out of the backfield in New York's last contest, hauling in five passes for 67 yards, and looks to be fully healed from an ankle injury suffered earlier in 2015.
Just six touches and 26 yards for Shane Vereen in the loss to New England after two straight games of 10 touches.
LeGarrette Blount has received at least 16 carries in each of the last four games, but faces a Denver Broncos defense allowing just 93.7 rushing yards per game, which is 7th in the NFL.
James White scored two touchdowns Monday against the Bills, but had just four touches in all and faces a Denver Broncos defense allowing the fewest yards in the NFL.
Mark Ingram will have his work cut out for him against a Texans defense that’s allowed one 100-yard rusher and no rushing touchdowns since Week 7.
Even with Mark Ingram sidelined for lengthy stretches, C.J. Spiller was unable to do much with his chances (eight carries, 24 yards; two receptions, 10 yards) and goes up against the tough Texans defense.
Matt Jones' continued ball security issues had him on the sidelines for the bulk of the Carolina game, though the injury to Alfred Morris could open the door again.
Ameer Abdullah seems likely to see increased opportunities as the season winds down and is coming off of his third-highest number of carries last Sunday, and now faces an Eagles defense that is allowing 128.5 yards per game on the ground.
The veteran Tim Hightower saw a team-high 11 carries thanks to the blowout but likely won’t factor too much into the fantasy mix with a healthy and rested Ingram.
Alfred Blue is averaging just 39.2 yards per game, but has a good matchup in Week 12 when the Houston Texans face the New Orleans Saints, the league's 29th-ranked rushing defense (131.2 ypg).
Devonta Freeman—who has just 55 rushing yards over his past two games—goes up against a Vikings defense that allowed their first 100-yard rusher last week since Week 4.
Draughn figures to continue shouldering the load in the San Francisco ground game for as long as Carlos Hyde remains sidelined but a Week 12 matchup against the Cardinals figures to limit Draughn's upside.
Rashad Jennings led the Giants with a modest 11 carries in Week 10 but hasn't scored a rushing touchdown since Week 1.
Tevin Coleman had just 2.8 yards per carry last week and—if Devonta Freeman can’t go—will be the bell cow against the Vikings highly touted front.
Chris Thompson had just 17 total yards in the loss to Carolina but could be looking at an uptick in usage with the injury to Alfred Morris and the continued fumbling problems from Matt Jones.
Jonathan Grimes was part of the Houston Texans' version of the Wildcat offense unveiled in Week 11 and he looks to capitalize on the success he had in Week 12 when they play the New Orleans Saints, who rank last in overall defense (424.3 total ypg).
Charles Sims’ usage will prevent him from being a top fantasy option, but his pass catching ability should help him against the sub-par Colts defense.
Orleans Darkwa's five carries trailed only Rashad Jennings in the loss to New England but has just 103 yards on 23 carries teh past four games as the committee approach continues.
Johnson's primary value comes from his use on special teams but he's slowly emerging as a receiving threat out of the backfield and will look to continue that trend against the 49ers in Week 12.
Denard Robinson's played just 21 offensive snaps the last two weeks for the Jacksonville Jaguars as they prepare for a Week 12 game against the San Diego Chargers.
Stevan Ridley had five touches for negative-five yards Sunday and remains behind both Chris Ivory and Bilal Powell on the depth chart.
Ellington takes a back seat to Chris Johnson in the running game and is beginning to yield some looks in the passing game to rookie David Johnson in the Arizona offense and remains inconsistent as a result.
Theo Riddick is coming off of a season-high 11 touches and 86 yards and while he continues to do the bulk of his damage in the passing game, he's been held to three catches in three of his last five games.
Ryan Mathews missed the game against Tampa Bay due to a concussion and didn't practice Monday under the NFL's concussion protocol, clouding his availability for the short week against Detroit.