Rob Gronkowski faces an Indianapolis Colts defense that has allowed eight passing touchdowns in 2015, tied for 19th in the NFL.
Fitzgerald has cooled off a bit, but he's still the top receiving option in an excellent offense, and he'll face a soft Pittsburgh secondary in Week 6.
Julian Edelman faces an Indianapolis Colts defense that is allowing 287 passing yards per game, which is 28th in the NFL.
Dion Lewis has become a vital part of the New England passing attack and clashes with an Indianapolis Colts defense ranked 28th in the league in defending the pass.
Tom Brady, sure to be motivated by last year's Deflategate saga, faces an Indianapolis Colts defense that is 28th in the NFL in terms of passing yards allowed this season.
Stephen Gostkowski has hit at least three field goals in three-straight games and faces the 16th ranked scoring defense of the Indianapolis Colts.
Palmer shouldn't have much trouble building on his early-season success in a matchup with the shaky Pittsburgh secondary.
Catanzaro should eventually see some of his extra points turn to field goals, and the Cardinals shouldn't have too much trouble moving the ball against the Steelers.
Emmanuel Sanders is coming off his first 100-yard game of the season, and could thrive Sunday against a beat-up Browns secondary allowing 7.9 yards per pass attempt.
Lacy could break out against a Chargers defense that is allowing 130.2 yards per game on the ground through five weeks.
Carves up Saints' defense for 333 yards and now faces a Giants' defense allowing a league-worst 304.2 passing yards per game.
13 field goals through five weeks lead the league.
Bennett's volume remains high, having 24 targets in the past two weeks, something that is unlikely to decrease unless Alshon Jeffery and Eddie Royal are both active for Week 6 at Detroit.
Larry Fitzgerald is still the go-to guy, but there should be enough to go around for both him and Brown against a soft Pittsburgh secondary.
Peterson is averaging 5.0 yards per carry but faces a Chiefs defense that is giving up only 3.9 per tote, making him just one of the top options in Week 6 instead of the top choice.
Rodgers seems likely to bounce back from a three-turnover performance against a Chargers defense that allowed Browns' quarterback Josh McCown to throw for 356 yards and two scores two weeks ago.
Brandon McManus remains perfect on the season and gets another opportunity for a productive game Sunday against a Browns defense allowing 26.7 points per game.
Boldin may be stuck in a highly questionable offense, but he's the clear top receiving option and gets to face a weak Baltimore pass defense.
Brandon Marshall has three-straight 100-yard games to his credit, though will face a Washington Redskins defense allowing just 216.4 yards per game through the air.
Le'Veon Bell is the unquestioned workhorse for the Pittsburgh Steelers, guaranteed to be among the NFL leaders in touches on a game-to-game basis, including this week against a strong Arizona Cardinals squad that has only given up two rushing touchdowns this season.
Jeremy Maclin was already on pace for a career year and could see a larger role in the offense with Jamaal Charles out for the season, but he has a tough matchup Sunday against a Vikings defense allowing just 6.7 yards per pass attempt, the 7th-best mark in the league.
Antonio Gates didn't miss a beat in his return from a four-game suspension, catching two touchdowns passes in Week 5, and despite facing a Packers defense Sunday that's been tough on tight ends he could have another big game if the Chargers fall into an early hole and have to play catch-up.
Record-setting day against the 49ers, but receiving corp could be thinned with hamstring injuries to Odell Beckham and Rueben Randle.
Philip Rivers has a tough road matchup Sunday against a Packers defense allowing a 62.8 QB rating, second-best mark in the league, but he could still have a productive high-volume game if the Chargers fall behind Aaron Rodgers early.
Seven targets and the game-winning score, though he was held to under 40 yards for the fifth straight game.
Kendall Wright is the Tennessee Titans' leading target as they prepare for a Week 6 match-up against the Miami Dolphins, who rank 20th in points allowed per game.
Marcus Mariota and the Tennessee Titans have a Week 6 match-up against the Miami Dolphins, who have allowed 25 points per game.
Antonio Brown is one of the best receivers in the NFL when Ben Roethlisberger is playing quarterback but has yet to establish a rhythm with Michael Vick, and will be challenged to do so this week against a strong Arizona Cardinals defense that leads the NFL in interceptions.
Josh Lambo has had an inconsistent rookie season so far, but despite facing a Packers defense Sunday allowing just 16.2 points per game he could get plenty of scoring chances as Philip Rivers attempts to keep pace with Aaron Rodgers.
Cobb remains a threat to go off at any moment as Aaron Rodgers favorite target, but against a Chargers defense that is struggling against the run, expectations for Cobb this week can be kept in check.
Eight catches against the 49ers after curiously targeted just three times total in the prior two weeks makes him relevant again in PPR formats.
Kaepernick bounced back from a nasty slump in Week 5, and he now gets to face a porous Baltimore pass defense. Given his early-season struggles, it's still far from a sure thing.
Julius Thomas was a surprise activation last week and played about half of the Jacksonville Jaguars' snaps. He'll increase his role in Week 6 against the Houston Texans.
Eris Decker has scored a touchdown in every game he's played this season, though faces a surprisingly tough Washington Redskins defense allowing just 20.8 points per game.
Demaryius Thomas continues to see a high volume of targets with a career-low YPT, reducing his overall production, but Sunday's game against a Browns secondary allowing 7.9 yards per pass attempt could allow him to see more action downfield.
Melvin Gordon is still looking for his first touchdown and first 100-yard game in the NFL, but gets a great opportunity for both Sunday against a Packers defense allowing 5.0 yards per carry, third-worst mark in the league.
Tyrod Taylor continues his surprise campaign against a Cincinnati Bengals defense allowing 263 passing yards per game, which is 22nd in the NFL.
T.J. Yeldon suffered a groin injury last week and is sure to be in the injury report all week leading up to the Jacksonville Jaguars' Week home game against the Houston Texans, who rank 23rd in rushing yards allowed per game.
Dallas may be chasing touchdowns against the Patriots, limiting Bailey's opportunities.
Lamar Miller faces a Tennessee Titan defense allowing 117 yards per game on the ground, which is 23rd in the NFL.
Though the Bears rank fourth in the league in passing yards allowed, they have allowed 11 touchdowns while only taking two interceptions, giving Stafford a chance to jump-start his woeful season.
Keenan Allen is on pace for a career season and could have another high-target game Sunday if the Chargers fall behind early in Green Bay, although the Packers stingy secondary is allowing just 64 yards per pass attempt, sixth-best mark in the league.
The playbook creaked open a bit, giving Williams some coveted down field looks, in a loss to the Saints.
Allen Robinson's been the top target in the Jacksonville Jaguars' offense through five weeks, but will not start sharing the attention in Week 6 against the Houston Texans now that Julius Thomas has returned from a thumb injury.
Blake Bortles is dealing with a sprained AC joint in his throwing shoulder, but is expected to play Week 6 against the Houston Texans, who have given up over 736 yards passing the last two games.
Crosby has made just eight field goals through five games, but faces a Chargers defense that has allowed at least 24 points in all five games while three times allowing more than 30 points.
Hyde will face a Baltimore defense that begs for a pass-heavy approach, but he could see some extra targets if Reggie Bush (calf) doesn't play.
Iffy hamstring could hinder his otherwise attractive matchup for the week.
Delanie Walker averages over six targets per game, tops among tight ends, entering Week 6 when the Tennessee Titans face the Miami Dolphins.
Bridgewater has an inviting matchup against the Chiefs 27th ranked pass defense that is allowing 285 yards weekly, but questions remain about how often Bridgewater will be asked to throw.