Antonio Brown has an excellent match-up in Week 13 against a weak Indianapolis Colts pass defense that allows 272.8 yards per game through the air (27th in the NFL), but his upside is limited by the availability of quarterback Ben Roethlisberger, who is currently undergoing the NFL concussion protocol.
Tom Brady is missing his primary weapons on offense, but the Philadelphia Eagles defense has been torched for 10 touchdown passes over the last two games.
Tyler Eifert caught three passes for 40 yards and a touchdown on Sunday against the St. Louis Rams before leaving with a stinger, and if he is able to play in Week 13 he will face a Cleveland Browns defense that he burned for 53 yards and three touchdowns back in Week 8.
Martavis Bryant has at least 100 total yards and/or a touchdown in five of his six games since returning from suspension, and in Week 13 has a favorable match-up against a poor Indianapolis Colts pass defense that allows 272.8 yards per game through the air (27th in the NFL).
Danny Amendola would be primed for a monstrous performance if deemed healthy, as neither Julian Edelman nor Rob Gronkowski will likely suit up against the hapless Philadelphia Eagles.
Ben Roethlisberger passed for 456 yards, a touchdown and two picks before leaving the game with a potential concussion on Sunday against the Seattle Seahawks, but if he's healthy enough to go in Week 13 he has a good match-up against a weaker Indianapolis Colts defense that allows 272.8 yards per game through the air and ranks 19th in the NFL in limiting production to opposing quarterbacks.
Andy Dalton completed 20 of 27 pass attempts for 233 yards, three touchdowns and an interception in Week 12 against the St. Louis Rams, almost exactly the same as the line he dropped on his Week 13 opponents, the Cleveland Browns, back in Week 8 (21 of 27, 234 yards, three touchdowns and zero interceptions).
Brandon Marshall has scored in four-straight games, collected his sixth 100-yard output of the season Sunday, and faces a New York Giants defense that is allowing a league-worst 309 passing yards per tilt.
Stephen Gostkowski had a streak of nine-straight games with at least two field goals snapped, but should be able to score with great frequency against an Eagles defense that has allowed 90 points over the last two contests.
DeAngelo Williams now has at least 100 total yards or a touchdown in five of the six games that he's started this season, and this week has a plus match-up against an Indianapolis Colts run defense that allows 115.1 yards per game on the ground, 24th in the NFL.
Catanzaro failed to put up double-digits for the first time in three weeks but still managed multiple field goal makes for the sixth straight week as the Cardinals prepare to travel to St. Louis in Week 13
Eddie Lacy has consecutive 100-yard outings and faces a Lions defense which ranks 23rd against the run, allowing 112.5 yards weekly and a league-high 15 rushing touchdowns, though only one in the past three weeks.
Palmer will look to rebound from a disappointing effort in Week 12 against the 49ers but doesn't have the easiest of matchups in a road game against a Rams pass defense that has allowed the eight fewest passing yards per game (230.0) and the fourth fewest passing touchdowns (12) through the first 12 weeks of the season.
Ronnie Hillman continues to split touches with C.J. Anderson, but faces a Chargers defense Sunday that's allowing 4.9 yards per carry this season, the worst mark in the league.
Aaron Rodgers faces a Lions pass defense that has been feast of famine this year, holding opposing quarterbacks under 200 yards five times but allowing at least 287 yards six times, including Rodgers' 333 yard, two touchdown Week 10 performance.
Kamar Aiken has 24 receptions on 38 targets over his last four games for 265 yards, has scored a Red Zone touchdown in two straight outings, and is Matt Schaub's primary wideout option going into a Week 13 match-up with a Miami Dolphins pass defense that is 21st in the NFL with 253.3 yards allowed per game and tied for third-to-last with 23 passing touchdowns allowed.
Jordan Reed led Washington in targets, yards and catches in the win over New York and the 98 yards were a season-high, making him one of the more reliable tight ends at the moment.
A.J. Green caught six passes for 61 yards and two touchdowns on Sunday against the St. Louis Rams, but had only four receptions for 53 yards back in Week 8 against the Cleveland Browns, his Week 13 opponent.
Eric Decker has scored eight touchdowns this season and will battle a New York Giants defense that has surrendered 20 passing scores in 2015, which is tied for 18th in the NFL.
Rawls racked up just 81 yards on 21 carries but managed a score in his first week since being anointed the starter for the injured Marshawn Lynch and should continue to see a heavy workload against the Vikings in Week 13.
Odell Backham hauled in another highlight reel-worthy touchdown catch against Washington and saw a season-high 18 targets in the loss, making the expected Beckham/Darrell Revis matchup appointment television.
Jarvis Landry is coming off the best game of his brief NFL career and faces a Baltimore Ravens defense in the bottom third of the NFL in passing defense.
Darren McFadden ran for just 11 yards on 10 carries, though he did add 45 receiving yards, against Carolina and should fare a good bit better against a poor Washington run defense.
Adrian Peterson continues to lead the league in rushing after gashing a solid Falcons rush defense last week, and faces a stiff test against a Seahawks defense that has not allowed an opposing rusher to top 98 yards to date.
Robbie Gould has five double-digit scoring games on the year and faces a 49ers defense that has allowed 35.2 points per game in their five road games this season.
Brandon McManus hasn't connected on multiple field goals in any of the last four games, but should get more opportunities Sunday against a Chargers defense allowing 27.9 points per game, 30th in the league.
C.J. Anderson is coming off his best game of the season, and while he's still sharing touches with Ronnie Hillman they get to face a Chargers defense Sunday allowing a league-worst 4.9 yards per carry.
Ryan Fitzpatrick tossed four touchdown passes Sunday and faces a New York Giants defense that has allowed 309 passing yards per game this season, which is by far the worst in the NFL.
Scott Chandler had 11 targets in Sunday's loss to the Broncos, and should see plenty of action against the lifeless Philadelphia Eagles defense due to the injury to Rob Gronkowski.
Jeremy Maclin returned to form last week with a season-high 160 receiving yards, and faces a Raiders defense Sunday allowing 282.7 passing yards per game, fourth-worst in the league.
Tasked with just extra points in the loss to Carolina, Dan Bailey's value takes a further hit with quarterback Tony Romo sidelined again - this time for the season.
Baldwin was trending upwards even before last week's explosion (six catches, 145 yards and three touchdowns) and figures to have a larger role with the season-ending injury to tight end Jimmy Graham but he'll have a hard time repeating his performance against a stingy Vikings secondary in Week 13.
Todd Gurley found little room to run against the Bengals, finishing with just 19 yards on nine carries, and has just 130 yards rushing over the last three weeks as team's simply stack against the run given the Rams passing attack and figures to have another tough game against the Cardinals in Week 13 despite his obvious talent.
Johnson could be looking at a big uptick if the injuries to Chris Johnson and Andre Ellington land Johnson the starting role but may get off to a sluggish start against a Rams defense that has allowed just six rushing scores to date this season.
Shaun Draughn continues to dominate the touches out of the San Francisco backfield (15 carries, five catches in Week 12) and figures to continue doing so until Carlos Hyde returns and could make for a sneaky option against a Bears defense that is allowing the fourth-most rushing yards per game (128.5) this season in Week 13.
Cairo Santos has kicked multiple field goals in three straight games, and faces a Raiders defense Sunday allowing 25.5 points per game, 26th in the league.
Chris Boswell made all three of his field goal attempts and his only extra point attempt on Sunday against the Seattle Seahawks, and in Week 13 faces an Indianapolis Colts defense that has allowed 1.6 made field goals per game on the season.
LeSean McCoy has scored in three of the last four games, but faces a Houston Texans defense that has allowed just two total touchdowns over the last four contests.
Sam Bradford was unable to suit up for the Detroit loss, though his participation in pregame warm ups bodes well for his activation for the game against New England.
Calvin Johnson doubled his season touchdown total last week and faces a Packers defense this Sunday that he's scored against four times in their last six meetings.
Demaryius Thomas struggled badly with drops last week despite a high target volume, but gets a Chargers defense Sunday allowing 8.2 yards per pass attempt, second-worst in the league.
Blaine Gabbert has been surprisingly functional since taking over the starting duties, throwing for 318 yards and a score against the Cardinals in Week 12, and may have to air it out against the Bears in Week 13 with the 49ers allowing 35.2 points per game on the road this season.
Emmanuel Sanders looked healthy and back in form last week, and faces a Chargers defense Sunday allowing 8.2 yards per pass attempt, second-worst in the league.
Matt Forte saw three more carries than Jeremy Langford last week, but Langford got the goal line work, and while both remain involved enough in the passing attack, they'll continue to suck value out of each other heading into a matchup against a 49ers defense that is allowed 121.1 yards on the ground and 12 touchdowns.
Heath Miller caught five passes for 45 yards on Sunday against Seattle, and would have a favorable match-up in Week 13 against an Indianapolis Colts defense that is 20th in the NFL at limiting production to the opposing tight end if his ribs and quarterback Ben Roethlisberger's head are both healthy enough to play.
Brandon LaFell was targeted nine times Sunday and should continue to see plenty of work against a poor Eagles defense since New England has been ravaged by injuries on the offensive side of the ball.
DeSean Jackson caught a long touchdown for the second straight week, though had just two catches total, but big-play threat makes him a nice flex play.
Mason Crosby has connected from 50 yards or longer twice in two weeks and has eight field goals and only three extra points in his last three games, possibly setting himself up for another busy day if the Packers struggle in the red zone against Lions defense that has allowed only five touchdowns in their last three games.
Dez Bryant was held to just two catches on eight targets in the Carolina loss, and with be without Tony Romo for the reminder of the season.
Chris Ivory got back into the scoring column Sunday and faces a New York Giants defense that has been mediocre against the run in 2015.