Dixon isn't going to break off many long gains, but he could be in for a heavy Week 5 workload against a questionable defense, as teammates LeSean McCoy (hamstring) and Karlos Williams (concussion) are both in danger of missing the game.
While he may not catch 80-yard touchdown passes every week, C.J. Spiller gets a good matchup in PPR leagues against an Eagles team that's allowed more than 50 receiving yards to running backs per game.
Danny Woodhead could struggle to score Monday against a Steelers defense that has allowed only one rushing TD on the season, but backs with similar skill sets such as Justin Forsett and Dion Lewis have managed big performances this year against them.
Johnson turned in a solid performance against the Rams in Week 4 (16 carries, 83 yards) but his value going forward will depend on his ability to keep his starting role with the return of Andre Ellington.
Riddick is averaging five catches through four games, giving him some appeal for an offense that is averaging a mere 47.0 yards per game on the ground.
With DeMarco Murray healthy, Sproles' workload will be hard to predict each week, and he's unlikely to get double-digit touches in any given game.
Johnson turned 10 targets into four catches and his fourth TD of the season in a Week 4 loss but the expected return of running back Andre Ellington figures to slide him down the depth chart so he'll need to make the most of his limited touches against the Lions in Week 5.
Ronnie Hillman ripped off a 72-yard touchdown run in Week 4 en route to a 100-yard day, but remains in a time share with C.J. Anderson and will be facing a Raiders defense Sunday allowing just 3.8 yards a carry.
Found the end zone, but still hasn't eclipsed 13 carries in any one game despite the starters' tag.
Took a backseat after leading the Washington backfield in snaps the week prior, but could emerge again in a possible high-scoring affair against the Falcons.
Charles Sims will hope to regain his role as the primary passing-down back for the Bucs in Sunday's matchup against the Jags after being beat out by Doug Martin for the most receptions out of the backfield last week (five-to-three).
Bush could see a higher percentage of the snaps if San Francisco is forced into passing situations and will look to take advantage of the league's worst pass defense (316.3 yards per game) when the opportunity arises.
Bishop Sankey is the lead back in a committee in the Tennessee Titans' backfield entering a Week 5 game against the Buffalo Bills, who rank third in rushing yards allowed per game.
Has led the team with 25 carries the past two weeks, albeit for just 64 yards, and gets to face off a San Francisco 49ers defense allowing nearly 28 points a game.
A tough matchup against a Bengals defense that hasn't allowed a rushing score this season and the expected return of Marshawn Lynch should have you steering clear of Rawls in Week 5.
Knile Davis failed to receive an offensive snap for the second straight game in Week 4, but he should see a few more opportunities Sunday in a matchup against a weak Bears run defense that could require him to give Jamaal Charles the occasional breather.
Roy Helu saw his first carries of the season and scored his first touchdown last week, but touches will be scarce Sunday for Latavius Murray's main backup against a stingy Broncos defense allowing just 90.2 rushing yards per game.