Allen Robinson leads the Jacksonville Jaguars in receptions, yards and is tied in touchdowns entering a Week 12 matchup against the San Diego Chargers, who rank 17th in passing defense (247.5 ypg).
Odell Beckham enters the game against Washington with three-straight 100-yard games and 38 targets over the same three-game stretch.
Gary Barnidge got good news with the return of Josh McCown as the starting quarterback in Cleveland, as Barnidge averaged 85.3 yards and a touchdown per game while playing with McCown, and this week has a good match-up gainst a Baltimore Ravens pass defense that is 24th in the NFL with 257 passing yards allowed and that is tied for 23rd with 19 passing touchdowns allowed this season.
DeAndre Hopkins will look to pad his stats in Week 12 when the Houston Texans air it out against the New Orleans Saints, who rank 30th pass defense (290.5 ypg).
Tyler Eifert caught two more touchdown passes in Week 11 against the Arizona Cardinals to build his NFL-leading receiving touchdown total up to 12, but this week faces a stiff challenge in a St. Louis Rams pass defense that has only allowed a league-best eight passing touchdowns all season.
Rawls ran over the 49ers for 255 yards of total offense and a pair of touchdowns in Week 11 but will have a hard time replicating those numbers against a Steelers defense that has allowed three rushing touchdowns all season as he handles the lead back duties with the injury to Marshawn Lynch.
Jordan Reed failed to find the end zone for the firs time in four weeks, but gets to take on a shaky New York Giants' pass defense provided Reed's minor knee injury doesn't keep him sidelined.
Giovani Bernard showed off his explosive pass-catching ability in Week 11 that allowed him to produce 146 total yards against the Arizona Cardinals, which should help him this week he faces a St. Louis Rams defense that allows 108.1 yards per game on the ground but has only allowed six rushing touchdowns all season.
DeAngelo Williams had a down game against the Cleveland Browns in Week 10 but had averaged 150 yards and 1.7 touchdowns in three starts previous to that one, and this week he faces a tough Seattle Seahawks run defense that allows only 96.4 yards per game on the ground.
Delanie Walker leads the Tennessee Titans in all the major receiving categories entering their Week 12 battle against the Oakland Raiders, who rank 30th in passing defense (290.5 ypg).
Calvin Johnson has at least 81 yards in five straight games and will face an Eagles defense Thursday that is allowing 246 yards per game and 20 receiving touchdowns, 14 of which have gone to opposing wide receivers.
Brandon Marshall continues to play through injury, but has scored in three-straight outings and had seven catches for 128 yards when the Jets faced the Dolphins earlier this season.
Doug Martin probably won’t get 235 rushing yards again this week, but does get a good matchup against the poor Colts run defense.
Brandon LaFell has been targeted at least six times in five-straight games, and should continue to see plenty of looks due to the injuries to Julian Edelman and Danny Amendola.
Chris Ivory has failed to rush for 100 yards in five-straight games, but faces a Miami Dolphins defense that has been gutted for 138.6 yards per game on the ground; Ivory ran for 166 yards and a touchdown in the first meeting between the two squads.
Eric Decker had a three-game scoring streak snapped this past weekend, but could get back into the end zone against a Miami Dolphin defense that has yielded 19 passing scores in 2015, which is tied for 23rd in the league.
Coming off a relative down week, Mike Evans should bounce back against a Colts secondary that’s allowed five 100-yard receivers this season.
Michael Crabtree is on pace for a career season, and has an exploitable matchup Sunday against a Titans defense allowing 8.0 yards per pass attempt, fifth-worst in the league.
Johnson's found little room to run the last two weeks against a pair of stingy run defenses but his continued dominance of the workload out of the backfield should bear fruit against a leaky San Francisco run defense in Week 12.
DeSean found the end zone for the first time this year against Carolina among his eight targets and gets a nice matchup against a poor pass defense this week.
LeSean McCoy is averaging 102 yards per game over his last three contests, at a rate of 5.6 yards per tote, but clashes with a Kansas City Chiefs defense that is fourth in the NFL in rushing yards allowed this season.
Fitzgerald's TD pace has slowed but he's still averaging 13 targets over the last three weeks and could be in for another big game against the 49ers in Week 12.
Dez Bryant scored just his second touchdown of the season in the win over Miami, and finally gets to take the field again with a healthy Tony Romo.
Julius Thomas' production has been disappoint in his first season with the Jacksonville Jaguars, but he's coming off a week when he scored the game-winning touchdown as the Jaguars prepare for a Week 12 game against the San Diego Chargers, who rank 11th in passing touchdowns allowed (16).
Cecil Shorts is healthy again after missing a couple of games with a hamstring injury and Week 12 could be a good one for the Houston Texans' receivers against the New Orleans Saints, who rank 30th in pass defense (290.5 ypg).
Steve Johnson remains Philip Rivers' most experienced healthy receiver, and could continue to see a high target volume Sunday against a Jaguars defense that ranks 25th in passing yards allowed.
Jacob Tamme had his worse game since September against the Colts, but will have a chance to bounce-back against the Vikings’ middling defense against tight ends.
Kamar Aiken led the Baltimore Ravens in receptions, targets, and scored the only touchdown on Tuesday but will have to establish chemistry with new quarterback Matt Schaub this week against a Cleveland Browns defense that is 26th in the NFL in passing yards allowed and 30th in passing touchdowns allowed.
Rob Gronkowski is coming off his worst outing of the season and faces a Denver Broncos defense that is ranked No. 1 against the pass.
Baldwin continues to hold some value in PPR formats by leading the Seattle passing attack but will need to shake off a low-ankle sprain as Seattle hosts the Steelers in Week 12.
DeMarco Murray carried the ball just 13 times in a blowout loss to the Buccaneers but should see a bump against Detroit with Ryan Mathews expected to remain sidelined with a concussion.
Randall Cobb is on pace for only 885 yards but has seen at least nine targets in four straight games while scoring in two, and faces a Bears defense that has allowed 19 receiving touchdowns to date, including one to Cobb in Week 1.
Demaryius Thomas caught just his second TD pass of the season last week, and may not see his usual volume of targets Sunday against a Broncos defense that's allowing a league-low 18.2 points per game.
Graham's YPC (12.0) remains in line with his career average but a lack of volume and red zone looks continue to haunt him in Seattle but he should have a chance to reverse the downward slide against the Steelers in Week 12.
Antonio Brown re-connected with Ben Roethlisberger in Week 10 to predictably huge results, but this week faces a tough test against a Seattle Seahawks defense that is second in the NFL with only 207.2 yards allowed through the air per game.
A.J. Green caught four passes for 79 yards in Week 11, still with only one touchdown or 100-yard game since Week 3, and this week has a challenging match-up against a St. Louis Rams pass defense that allows 229.4 yards per game but has only given up eight touchdowns through the air all season.
Golden Tate tied a season-high with eight catches last week and now faces an Eagles defense that has twice allowed a pair of opposing receivers to top 100 yards and has given up six touchdowns to receivers in their last three games.
Kyle Rudolph's 106 yard performance last week may look like a blip on the radar for a player who had 182 yards in the nine previous games, but he faces a Falcons defense that has allowed seven touchdowns to opposing tight ends in 10 games.
Julio Jones could go up against Ronnie Lott in his prime and still put up good numbers, but will have his work cut out for him against a tough Vikings secondary.
Danny Woodhead saw just two targets in last week's loss, but should see a much higher volume Sunday against a Jaguars defense that's had difficulty containing pass-catching backs and ranks 25th in passing yards allowed.
Alshon Jeffery could return to action Thursday after missing last week's game due to a groin injury, and would face a Packers defense that has allowed only three opposing receivers to top 100 yards to date.
Marquess Wilson could function as the team's second receiver Thursday against the Packers with Eddie Royal and tight end Martellus Bennett both dealing with injuries, giving him a chance to build on last week's 102 yard performance.
Antonio Andrews has averaged 58 yards rushing per game and had a favorable Week 12 matchup against the Oakland Raiders, who rank 23rd in rushing defense (114.7 ypg).
Spencer Ware had a career game last week after Charcandrick West was injured and, if West's hamstring keeps him sidelined Sunday, would be in line for a start against a Bills defense more vulnerable against the run than the pass.
Latavius Murray hasn't topped 100 yards from scrimmage in three games, but faces a Titans defense Sunday that's allowed 110.1 rushing yards a game and nine rushing TDs, ranking in the bottom half of the league in both categories.
Amari Cooper has the worst game of his career in Week 11, but will look to rebound Sunday against a Titans defense that's allowed 8.0 yards per pass attempt this season, fifth-worst in the league.
Sammy Watkins has six catches for just 53 yards over his last two games, but faces a Kansas City passing defense that is in the middle of the pack in terms of passing yards and touchdowns surrendered this season.
Brandin Cooks is coming off his best game of the season (5-98-2), but goes up against a Texans defense that’s shut down A.J. Green and Brandon Marshall in back-to-back weeks.
Brown was limited by a hamstring but still managed three catches and a touchdown in Week 11 and could see a heavier workload if wideout Michael Floyd is unable to go again in Week 12 against San Francisco.
Martavis Bryant exploded for 178 yards and a touchdown in his last outing against the Cleveland Browns, but this week has a much tougher test against the Seattle Seahawks and their Legion of Boom secondary, a unit that is second in the NFL with only 207.2 yards per game allowed through the air.