Allen Robinson leads the Jacksonville Jaguars in receptions, yards and is tied in touchdowns entering a Week 12 matchup against the San Diego Chargers, who rank 17th in passing defense (247.5 ypg).
DeAndre Hopkins will look to pad his stats in Week 12 when the Houston Texans air it out against the New Orleans Saints, who rank 30th pass defense (290.5 ypg).
Palmer overcame some early turnovers and torched the Bengals for 317 yards and four touchdowns and will look to continue his recent hot streak against the 49ers in Week 12.
Odell Beckham enters the game against Washington with three-straight 100-yard games and 38 targets over the same three-game stretch.
Gary Barnidge got good news with the return of Josh McCown as the starting quarterback in Cleveland, as Barnidge averaged 85.3 yards and a touchdown per game while playing with McCown, and this week has a good match-up gainst a Baltimore Ravens pass defense that is 24th in the NFL with 257 passing yards allowed and that is tied for 23rd with 19 passing touchdowns allowed this season.
Brandon Marshall continues to play through injury, but has scored in three-straight outings and had seven catches for 128 yards when the Jets faced the Dolphins earlier this season.
Michael Crabtree is on pace for a career season, and has an exploitable matchup Sunday against a Titans defense allowing 8.0 yards per pass attempt, fifth-worst in the league.
Josh Brown connected on all four field goal attempts and both extra points in the loss to New England, vaulting him to third overall in kicker scoring through the first 11 weeks.
Andy Dalton exploded for 315 passing yards and two touchdowns against the Arizona Cardinals on Sunday, and faces another tough test this week against a St. Louis Rams defense that allows 229.4 passing yards per game but has only given up eight touchdowns all season through the air.
DeSean found the end zone for the first time this year against Carolina among his eight targets and gets a nice matchup against a poor pass defense this week.
Johnson's found little room to run the last two weeks against a pair of stingy run defenses but his continued dominance of the workload out of the backfield should bear fruit against a leaky San Francisco run defense in Week 12.
Travis Coons was 1-for-1 in field goals but 0-for-1 in extra points in his last outing in Week 10, and takes his average of 1.6 made field goals per game into a game with a Baltimore Ravens defense that allows 2.4 made field goals per game (tied for 2nd most in the NFL).
Catanzaro continues to enjoy kicking for a high octane offense and should be in for another big game against the 49ers in Week 12.
Doug Martin probably won’t get 235 rushing yards again this week, but does get a good matchup against the poor Colts run defense.
LeSean McCoy is averaging 102 yards per game over his last three contests, at a rate of 5.6 yards per tote, but clashes with a Kansas City Chiefs defense that is fourth in the NFL in rushing yards allowed this season.
Eric Decker had a three-game scoring streak snapped this past weekend, but could get back into the end zone against a Miami Dolphin defense that has yielded 19 passing scores in 2015, which is tied for 23rd in the league.
Rawls ran over the 49ers for 255 yards of total offense and a pair of touchdowns in Week 11 but will have a hard time replicating those numbers against a Steelers defense that has allowed three rushing touchdowns all season as he handles the lead back duties with the injury to Marshawn Lynch.
Chris Ivory has failed to rush for 100 yards in five-straight games, but faces a Miami Dolphins defense that has been gutted for 138.6 yards per game on the ground; Ivory ran for 166 yards and a touchdown in the first meeting between the two squads.
Dez Bryant scored just his second touchdown of the season in the win over Miami, and finally gets to take the field again with a healthy Tony Romo.
Aaron Rodgers has eight touchdowns in his last three games, and faces a Bears defense which he has lit up for 13 scores in his last three games against
Eli Manning now has two 300+ yard efforts in his last three games following a 361-yard effort against the Patriots back in Week 10.
Fitzgerald's TD pace has slowed but he's still averaging 13 targets over the last three weeks and could be in for another big game against the 49ers in Week 12.
Justin Tucker made three of his five field goal attempts (long of 47 yards) and his only extra point in Week 11 against the St. Louis Rams, and this week takes his average of 2.2 made field goals per game up against a Cleveland Browns defense that allows 1.8 made field goals per game.
Cairo Santos has kicked multiple field goals in three of his last four games, and faces a Bills defense Sunday that ranks in the middle of the league in points allowed and red zone stops, likely provided him with more FG opportunities.
Calvin Johnson has at least 81 yards in five straight games and will face an Eagles defense Thursday that is allowing 246 yards per game and 20 receiving touchdowns, 14 of which have gone to opposing wide receivers.
Derek Carr should rebound from a poor Week 11 performance Sunday against a Titans defense allowing 8.0 yards per pass attempt, fifth-worst in the league.
Jordan Reed failed to find the end zone for the firs time in four weeks, but gets to take on a shaky New York Giants' pass defense provided Reed's minor knee injury doesn't keep him sidelined.
DeAngelo Williams had a down game against the Cleveland Browns in Week 10 but had averaged 150 yards and 1.7 touchdowns in three starts previous to that one, and this week he faces a tough Seattle Seahawks run defense that allows only 96.4 yards per game on the ground.
Coming off a relative down week, Mike Evans should bounce back against a Colts secondary that’s allowed five 100-yard receivers this season.
Josh McCown has been reinstated as the starting quarterback for the Cleveland Browns, just in time for a match-up with a poor Baltimore Ravens pass defense that he torched for 457 yards and two touchdowns back in Week 5.
Delanie Walker leads the Tennessee Titans in all the major receiving categories entering their Week 12 battle against the Oakland Raiders, who rank 30th in passing defense (290.5 ypg).
Stephen Gostkowski missed his first field goal of the season Monday, but remains the top scoring kicker in the NFL, and will still be valuable despite playing against a Denver Broncos squad allowing just 18.3 points per game.
Giovani Bernard showed off his explosive pass-catching ability in Week 11 that allowed him to produce 146 total yards against the Arizona Cardinals, which should help him this week he faces a St. Louis Rams defense that allows 108.1 yards per game on the ground but has only allowed six rushing touchdowns all season.
Tyler Eifert caught two more touchdown passes in Week 11 against the Arizona Cardinals to build his NFL-leading receiving touchdown total up to 12, but this week faces a stiff challenge in a St. Louis Rams pass defense that has only allowed a league-best eight passing touchdowns all season.
Rob Gronkowski is coming off his worst outing of the season and faces a Denver Broncos defense that is ranked No. 1 against the pass.
Julio Jones could go up against Ronnie Lott in his prime and still put up good numbers, but will have his work cut out for him against a tough Vikings secondary.
Sam Bradford missed the game against Tampa Bay but practiced Monday and would get the start against Detroit if healthy.
Adrian Peterson faces a Falcons rush defense that is a bit of an enigma, having allowed 11 rushing touchdowns, the third most in the league, but a league-low 87.4 yards per game through 10 contests.
Golden Tate tied a season-high with eight catches last week and now faces an Eagles defense that has twice allowed a pair of opposing receivers to top 100 yards and has given up six touchdowns to receivers in their last three games.
Demaryius Thomas caught just his second TD pass of the season last week, and may not see his usual volume of targets Sunday against a Broncos defense that's allowing a league-low 18.2 points per game.
Brandon LaFell has been targeted at least six times in five-straight games, and should continue to see plenty of looks due to the injuries to Julian Edelman and Danny Amendola.
Josh Lambo was held down last week by the Chargers' struggling offense, failing to kick multiple field goals for the first time since Week 3, but faces a Jaguars defense Sunday that's 28th in the league with 26.8 points per game allowed.
A.J. Green caught four passes for 79 yards in Week 11, still with only one touchdown or 100-yard game since Week 3, and this week has a challenging match-up against a St. Louis Rams pass defense that allows 229.4 yards per game but has only given up eight touchdowns through the air all season.
Antonio Brown re-connected with Ben Roethlisberger in Week 10 to predictably huge results, but this week faces a tough test against a Seattle Seahawks defense that is second in the NFL with only 207.2 yards allowed through the air per game.
Danny Woodhead saw just two targets in last week's loss, but should see a much higher volume Sunday against a Jaguars defense that's had difficulty containing pass-catching backs and ranks 25th in passing yards allowed.
Graham's YPC (12.0) remains in line with his career average but a lack of volume and red zone looks continue to haunt him in Seattle but he should have a chance to reverse the downward slide against the Steelers in Week 12.
Cam Newton’s been on fire of late, but goes up against a Cowboys defense that’s allowed an average of 225 passing yards per game over the past five weeks.
Graham Gano added three more field goals and is 11-for-12 on field goal attempts in November.
Steve Johnson remains Philip Rivers' most experienced healthy receiver, and could continue to see a high target volume Sunday against a Jaguars defense that ranks 25th in passing yards allowed.
Matt Prater has five made field goals in his last two games after connecting on only eight through the first eight games and will face an Eagles defense that has allowed at least nine points to four straight opposing kickers.