Jesse James will have a Week 7 tilt against the Patriots, who have given up 41 or more receiving yards to five opposing tight ends to start the season.
Will Tye and Larry Donnell are splitting time at tight end in an offense that prefers to throw to its wide receivers heading into Sunday's London game against the Rams.
Darren Sproles has a tough matchup Sunday against a Vikings defense that's allowing just 287.6 yards from scrimmage per game.
Phil Dawson has only attempted eight field goals this season, making him one of the less appealing Week 7 kicker options even as the 49ers take on the Buccaneers 28th ranked scoring defense that gives up 28.4 points weekly.
Andrew Franks hit a career-high three field goals last weekend but faces a Buffalo defense in Week 7 that's allowing just 17.2 points per game in 2016, which is fifth in the NFL.
Jerick McKinnon will continue splitting carries with Matt Asiata in Week 7 against an Eagles defense that just allowed their first 100-yard rusher of the season last week, but had previously not allowed more than 62 yards to any one back.
Dennis Pitta will face a Jets defense that’s given up at least 89 yards to two different tight ends this season.
Cody Parkey will take on the Bengals in Week 7 after having attempted 10 field goals over his last four games.
Matt Asiata remains the favorite for goal line carries but has been out-touched by Jerick McKinnon in three straight games, and now faces an Eagles defense that has allowed only three rushing touchdowns through five games.
Devontae Booker received praise from head coach Gary Kubiak after Week 6 and could see an expanded role going forward, starting with Monday's home game against a Texans defense that's allowing 126.3 rushing yards per game, 29th in the league.
Vance McDonald hasn't earned enough targets to earn much consideration Sunday against the Buccaneers.
Chris Hogan was unable to build off of a career performance, registering just one grab last weekend, though he will face a Pittsburgh defense on Sunday that's 29th in the NFL in passing yards allowed per game,
Larry Donnell will be competing with Will Tye for limited tight end targets against the Rams in Week 7.
Cordarrelle Patterson has seen six targets in each of his last two games and faces an Eagles secondary that has allowed five touchdown passes in the last two weeks.
Tyrell Williams saw just three targets in Week 6, but should be much more involved Sunday against a Falcons defense that's allowed 14 passing TDs through six games.
Cody Kessler will take on the Bengals Sunday, a defense that has allowed multiple touchdowns to five of the six quarterbacks they’ve faced this season.
Trevor Siemian was remarkably inefficient in Week 6's return from a shoulder injury, and could struggle to move the ball again Monday facing a Texans defense allowing an average QB rating of 80.4, seventh in the league.
Adam Thielen saw five or fewer targets in games where Stefon Diggs (groin) was healthy, and his prospects for Week 7 will be directly tied to Diggs' availability against an Eagles defense that allows only 207 yards per game through the air.
Quinton Patton was targeted seven times in Colin Kaepernick's debut under center, and will look to stay involved Sunday against the Buccaneers.
Lance Kendricks scored a touchdown last week, but a repeat is unlikely Sunday in London against a Giants defense that has allowed one touchdown to tight ends.
Matt Prater has scored between six and nine points in every game to date, averaging seven, making him a steady yet uninspiring option in Week 7 against a Redskins defense that is allowing 23.7 points per game.
Jack Doyle got more playing time in Week 6 due to an early injury to Dwayne Allen and caught his third touchdown of season. Depending on whether Allen's healthy, Doyle could be the Indianapolis Colts' lead receiving threat at tight end in Week 7 against the Tennessee Titans.
Bobby Rainey has some value as a pass-catcher, but Rashad Jennings will be the primary running back in Week 7 against the Rams.
Ryan Griffin, who overcame a concussion in order to play last week, has fallen behind C.J. Fiedorowicz as a target at tight end as the Houston Texans prepare for a Week 7 road game against the Denver Broncos, who rank 15th in yards allowed per game to tight ends.
Justin Forsett's role against a 28th-ranked Redskins rush defense is uncertain given the unknown health of Dwayne Washington and Theo Riddick.
Anquan Boldin had a season-high nine targets last week and could continue to see high volume should tight end Eric Ebron remain sidelined by an ankle injury in Week 7 against the Redskins, a defense that has allowed only three passing touchdowns since Week 1.
Ryan Succop ranks 36th in scoring with 5.0 points per game entering a potentially favorable matchup against the Indianapolis Colts, who rank 28th in scoring defense.
Roberto Aguayo may have made the game-winner before the bye week to boost his confidence, but at just 4-for-8 on field goals with a missed PAT to boot, the second-round pick is a tough play in Week 7 against the 49ers.
DeVante Parker has just 118 receiving yards and zero touchdowns in his last three games, and faces a Buffalo defense in Week 7 that's allowed a league-best three passing scores in 2016.
Alex Smith attempted a season-low 22 passes in Week 6 as the Chiefs primarily kept the ball on the ground, but he could rebound Sunday against a Saints defense allowing more than 300 passing yards a game.
Stefon Diggs missed practice early in the week while continuing to recover from a groin injury that has lingered through the team's bye week, putting his full health into question entering a matchup with the Eagles fourth-ranked pass defense.
Carson Wentz hasn't topped 250 yards since Week 3, and getting to that mark won't be easy Sunday against Minnesota's sixth-ranked pass defense.
Jaron Brown caught four balls last week, but his growing role still isn't large enough to be very impactful against Seattle's fifth-ranked pass defense Sunday.
DeAndre Washington has seen a slight increase in his touches while Latavius Murray has been sidelined, but Murray's potential return Sunday will limit his ceiling against a Jaguars defense allowing only 3.8 yards per carry, 12th in the league.
Landry Jones will have a Sunday matchup against the Patriots that hasn’t given up more than one touchdown pass to any of the last four quarterbacks they’ve faced.
Derrick Henry had his fewest rushing attempts of the season in Week 6 and does not appear to be a threat to DeMarco Murray in the Tennessee Titans' plan of attack as they enter a Week 7 home game against the Indianapolis Colts.
MarQueis Gray set career highs in receptions and yards last weekend, though those were his first statistics of the 2016 campaign.
Braxton Miller continues to battle Jaelen Strong for the Houston Texans' third wideout as they prepare for a Week 7 game against the Denver Broncos.
Theo Riddick's availability for Week 7 against the Washington Redskins is uncertain after he missed last week's contest due to an ankle injury.
Powell had six touches for just 22 yards last game, and faces a Ravens defense in Week 7 that's allowing the third-fewest yards per game in the NFL.
Quinn Enunwa saw his fewest targets of the season Monday, and the murky quarterback situation will not help matters facing a Ravens defense in Week 7 that's allowing just 225 passing yards per game this season.
Wendell Smallwood has carved out a small role in the Eagles backfield heading into Sunday's trip to Minnesota, but is still behind both Ryan Mathews and Darren Sproles.
Ryan Tannhill has failed to score a touchdown in two-straight games, and faces a Buffalo Bills defense on Sunday that has allowed a league-low three passing scores in 2016.
Geno Smith was called upon for mop up duty Monday, and it looks as though he will be the starter Sunday against a Baltimore Ravens defense that has eight interceptions already in 2016.
Charon Peake had a team-high 10 targets Monday night, but had just four targets for the entire season heading into the game, making this performance a likely aberration and not a recommended fantasy option Sunday against the Ravens.
Kenneth Dixon will have a Week 7 matchup against the Jets though he’s had just seven touches in his first two games of the 2016 season.
Charles Johnson has not caught more than two passes in a game this season and has only topped 15 yards once as the Vikings head to Philadelphia to face an Eagles defense that is allowing 207 yards per game through the air.
Caleb Sturgis will likely be starved for opportunities Sunday as the reeling Eagles face the undefeated Vikings on the road.
Virgil Green saw only four targets in his Week 6 return to the lineup, and will remain a secondary option in the Broncos' passing attack Monday against a Texans defense that's allowed only one TD to a tight end through six games.
Eric Ebron has missed two games due to an ankle injury and, should he return in Week 7, he'd face a Redskins defense that has allowed only one opposing tight end to score all season while none have topped 59 yards.