Leonard Hankerson, now the No. 2 receiver on the high-octane Falcons offense, should have another good week against the Redskins after his first 100-yard receiving day since 2011.
Gurley exploded in the second half on the way to 146 yards rushing against the Cardinals in Week 4 and figures to see a heavy workload against a Packers defense that is yielding 115.0 rushing yards per game and 4.8 YPC (third worst in the league) in Week 5.
Dixon isn't going to break off many long gains, but he could be in for a heavy Week 5 workload against a questionable defense, as teammates LeSean McCoy (hamstring) and Karlos Williams (concussion) are both in danger of missing the game.
Kendall Wright has benefited form better quarterback play this season and will face the league's 29th-ranked passing defense in Week 5 when the Buffalo Bills visit Nashville.
With 18 targets the past two weeks, Crowder makes for a sneaky play with a good matchup if DeSean Jackson remains sidelined this week.
Coby Fleener is moving ahead of Dwayne Allen as a target as the Indianapolis Colts enter a Week 5 meeting against the Houston Texans.
Baldwin gets a favorable draw against a Bengals defense that has allowed the sixth-most passing yards per game (279.0) through the first four weeks of the season in a Week 5.
The injury to Daniel Fells opens the door for a more expanded role.
Could benefit from the injury to tight end Jordan Reed on an offense that has thrown the ball 94 times the past two weeks.
Scored for the second straight week and spends another week as WR2 with the injury setback to Victor Cruz.
Royal's upside will tie directly to the availability of Alshon Jeffery, but facing a Chiefs defense that allows 296 yards and 31.3 points per game, there should be enough to go around for Royal.
Johnson turned in a solid performance against the Rams in Week 4 (16 carries, 83 yards) but his value going forward will depend on his ability to keep his starting role with the return of Andre Ellington.
Nate Washington is day-to-day with a hamstring injury leading up to Week 5, a Thursday night game against the Indianapolis Colts.
Davis was held out of Week 4 with a knee strain but could take advantage of a Giants defense that is yielding a league-high 316.3 passing yards per game if he's able to return in Week 5.
Lewis is averaging 15 touches per game despite the return of LeGarrette Blount, and facing a Cowboys defense that has allowed at least four catches to opposing running backs in every game this season bodes well for continued opportunities.
Antonio Gates returns from his suspension Monday to face a vulnerable Steelers defense that has given up four touchdowns and 7.8 yards per target to tight ends this season.
Donte Moncrief leads the Indianapolis Colts in touchdowns as the prepare for a Week 5 game against the Houston Texans.
Marques Colston will look to get more than the fifth-most targets on the team in Sunday's matchup against the poor Eagles secondary.
Delanie Walker will be three weeks removed from a wrist injury in Week 5 when the Tennessee Titans host the Buffalo Bills, who have allowed the third most receptions to opposing tight ends.
Garrett Graham remains an invisible element in the Houston Texans' offense and that doesn't figure to change in Week 5 against the Indianapolis Colts on Thursday.
Coming off of his first touchdown since October 16, 2014, Amendola remains fourth at best in the pecking order for targets from Tom Brady, making him hard to trust even against a Cowboys secondary that has allowed 307.5 yards per game in their last two contests.
The New Orleans defense provides favorable matchups for pretty much every offensive position, but Agholor is averaging just four targets per game.
Bishop Sankey is the lead back in a committee in the Tennessee Titans' backfield entering a Week 5 game against the Buffalo Bills, who rank third in rushing yards allowed per game.
Dorial Green-Beckham is on a roll, having caught touchdown passes in two straight games and looking to make it a third straight in Week 5 when the Tennessee Titans host the Buffalo Bills.
Charles Sims will hope to regain his role as the primary passing-down back for the Bucs in Sunday's matchup against the Jags after being beat out by Doug Martin for the most receptions out of the backfield last week (five-to-three).
Benjamin Watson continues to insert himself in the offense (3-30-0), but has yet to score a touchdown and faces an Eagles team on Sunday that’s yet to allow one to a tight end this season.
Ronnie Hillman ripped off a 72-yard touchdown run in Week 4 en route to a 100-yard day, but remains in a time share with C.J. Anderson and will be facing a Raiders defense Sunday allowing just 3.8 yards a carry.
Darrius Heyward-Bey has been outplaying Markus Wheaton for the second wide receiver slot, but both may take a backseat to the recently-returned-from-suspension Martavis Bryant as soon as this week against a San Diego Chargers team that is tenth in the NFL with 225 passing yards allowed per game.
Brandon Myers will look for more targets (three last week) in Sunday's matchup against the forgiving Jags' secondary.
Going up against the league's 28th ranked pass defense offers Wilson a chance to replicate last week's career-high 80 yard performance, but he would see a decrease in targets should Alshon Jeffery return from a hamstring injury.
Took a backseat after leading the Washington backfield in snaps the week prior, but could emerge again in a possible high-scoring affair against the Falcons.
Michael Crabtree could see more targets than usual Sunday as Derek Carr unloads the ball quickly against the league-leading Broncos pass rush, but it's unlikely to result in a spike in Crabtree's production.
Has led the team with 25 carries the past two weeks, albeit for just 64 yards, and gets to face off a San Francisco 49ers defense allowing nearly 28 points a game.
Even if healthy, Jacob Tamme is not a great option in Sunday's matchup with the Redskins for a Falcons offense where 10.4 percent of receptions have gone to tight ends.
Bush could see a higher percentage of the snaps if San Francisco is forced into passing situations and will look to take advantage of the league's worst pass defense (316.3 yards per game) when the opportunity arises.
Ellington should be back from a knee injury but another strong game from running back Chris Johnson (16 carries, 83 yards against the Rams) clouds the Arizona ground game picture in a Week 5 matchup against the Lions.
Marcedes Lewis had his first receptions of the season in Week 4, but there may be fewer targets in Week 5 when the Jacksonville Jaguars face the Tampa Bay Buccaneers, who are susceptible to the run.
Marqise Lee is dealing with a hamstring injury that leaves him questionable entering a Week 5 matchup against the Tampa Bay Buccaneers.
Austin may have a tough time repeating his Week 4 performance (six catches, 96 yards and two scores) against a Packers defense that has yielded just four passing touchdowns and under 200 yards passing per game this season.
Doug Martin will look to build off his first 100-yard day of the season on Sunday as the Bucs take on the Jaguars, who have allowed a league-low 3.1 yards per carry.
Kearse hasn't found the end zone but has topped 75 yards receiving in three of his four games this year as Seattle takes on a Bengals defense that is allowing the sixth-most passing yards per game (279.0) in the league so far.
Roddy White had his best game in weeks (2-8-0), but that would still net less than one fantasy point in non-PPR leagues.
Harry Douglas is averaging just 3.3 yards per target in the Tennessee Titans' high-volume offense as he enters a Week 5 game against the Buffalo Bills, who have given up the third most touchdowns to wideouts this year.
Mumphrey will take on a larger role as Cecil Shorts (shoulder) has been ruled out for the Houston Texans' Week 5 home game against the Indianapolis Colts.
Riddick is averaging five catches through four games, giving him some appeal for an offense that is averaging a mere 47.0 yards per game on the ground.
A tough matchup against a Bengals defense that hasn't allowed a rushing score this season and the expected return of Marshawn Lynch should have you steering clear of Rawls in Week 5.
Mychel Rivera has seen his role in the offense all but vanish due to the Raiders passing game being focused on Amari Cooper and Michael Crabtree, and Rivera isn't likely to improve his numbers Sunday against a Broncos defense that has yet to allow a touchdown to a tight end this season.
Chris Conley is emerging as the Chiefs' second-best wide receiver but won't see much target volume in a conservative offense unless the team is forced to play catch-up, something unlikely to happen Sunday against a Bears defense allowing a league-worst 31.3 points a game.
The Packers seem likely to rely on their top two receivers in a matchup against a stingy Rams pass defense which has allowed only three touchdown passes all season, likely leaving Montgomery in a struggle for opportunities Sunday.