Rawls ran over the 49ers for 255 yards of total offense and a pair of touchdowns in Week 11 but will have a hard time replicating those numbers against a Steelers defense that has allowed three rushing touchdowns all season as he handles the lead back duties with the injury to Marshawn Lynch.
Josh McCown has been reinstated as the starting quarterback for the Cleveland Browns, just in time for a match-up with a poor Baltimore Ravens pass defense that he torched for 457 yards and two touchdowns back in Week 5.
Coby Fleener is the Indianapolis Colts' third-leading target (55 in 10 games), but has scored just twice entering Week 12 against the Tampa Bay Buccaneers, who rank 30th with 21 passing touchdowns allowed.
With three touchdowns the last two weeks, Ahmad Bradshaw is getting more involved in the offense and that should continue in Week 12 when the Indianapolis Colts host the Tampa Bay Buccaneers, who rank 13th in overall defense (339.1 total ypg).
Brock Osweiler looked good in his first NFL start last week, but he'll have a tough challenge Sunday against a Patriots defense holding opposition quarterbacks to an 83.9 QB rating, ninth-lowest in the league.
Julius Thomas' production has been disappoint in his first season with the Jacksonville Jaguars, but he's coming off a week when he scored the game-winning touchdown as the Jaguars prepare for a Week 12 game against the San Diego Chargers, who rank 11th in passing touchdowns allowed (16).
After missing one game due to a concussion, Brian Hoyer will return to the lineup in Week 12 against the league's worst defense, the New Orleans Saints, who allow 424.3 total yards per game.
Golden Tate tied a season-high with eight catches last week and now faces an Eagles defense that has twice allowed a pair of opposing receivers to top 100 yards and has given up six touchdowns to receivers in their last three games.
Brent Celek racked up a season-high 79 yards on a team-leading 10 targets and could see similar volume against Detroit if Zach Ertz remains sidelined.
Larry Donnell missed his second straight game against New England but is expected back for the game against Washington and should resume his role as TE1.
Marquess Wilson could function as the team's second receiver Thursday against the Packers with Eddie Royal and tight end Martellus Bennett both dealing with injuries, giving him a chance to build on last week's 102 yard performance.
Floyd was absent in Week 11 due to a hamstring injury but will look to restart his four-game TD streak if he can get back into the lineup in Week 12 against San Francisco.
J.J. Nelson parlayed a hamstring injury to wideout Michael Floyd into an increased role in Week 11 and will look to build off that effort (four catches, 142 yards and a touchdown) if Floyd is unavailable again in Week 12 against San Francisco.
Adam Vinatieri is averaging nearly 10 points per game over the last three as the Indianapolis Colts prepare for a Week 12 meeting with the Tampa Bay Buccaneers, who allow 25.4 points per game (26th in NFL).
Kendall Wright, who has missed the Tennessee Titans' previous three straight due to a knee injury, is expected to play in Week 12 against the 30th-ranked passing defense, the Oakland Raiders, who give up 290.5 passing yards per week.
Nate Washington has just four catches for 45 yards the last two weeks, but his fortunes could change in Week 12 when the Houston Texans face the league's 30th-ranked pass defense in the New Orleans Saints.
Nick Novak, who hasn't missed a kick in three weeks, could get a workout in Week 12 when the Houston Texans face the New Orleans Saints, who rank last in the league with 31.5 points allowed per game.
Blake Bortles looks to lead the Jacksonville Jaguars to its third straight win in Week 12 when they face the San Diego Chargers, who rank 17th in pass defense (247.5 ypg).
Donte Moncrief, who's scored a team-high five touchdowns in 2015, looks to snap a three-week scoreless drought in Week 12 when the Indianapolis Colts host the Tampa Bay Buccaneers, who are 30th with 21 passing touchdowns allowed.
Cecil Shorts is healthy again after missing a couple of games with a hamstring injury and Week 12 could be a good one for the Houston Texans' receivers against the New Orleans Saints, who rank 30th in pass defense (290.5 ypg).
Robbie Gould has made six field goals in his last two outings and faces a Packers defense which he connected on three field goals and scored 11 points against in Week 1.
Kyle Rudolph's 106 yard performance last week may look like a blip on the radar for a player who had 182 yards in the nine previous games, but he faces a Falcons defense that has allowed seven touchdowns to opposing tight ends in 10 games.
Kai Forbath is just 1-for-2 on field goal attempts in four games with the Saints this season.
Jason Myers has made 10 field goals and is averaging 11.3 points per game over the last three entering the Jacksonville Jaguars' Week 12 home game against the San Diego Chargers, who are allowing 28.2 points per game (31st in NFL).
Duke Johnson continues to be out-carried by Isaiah Crowell but his receiving ability allows him to be the more effective back for the Cleveland Browns, and while Week 12 opponent the Baltimore Ravens is solid against the run (97 yards, 0.6 rushing touchdowns per game) they are weaker in pass defense (24th in the NFL with 257 passing yards allowed per game), which is Johnson's specialty.
Jacob Tamme had his worse game since September against the Colts, but will have a chance to bounce-back against the Vikings’ middling defense against tight ends.
Jason Witten had a disappointing two-catch, 27 yard effort in Tony Romo's return but should enjoy more success over the final few weeks with Romo under center.
Terrance Williams re-emerged to a state of fantasy relevance with the return of Tony Romo with a team-high 79 yards on four catches in the win over Miami.
Sam Bradford missed the game against Tampa Bay but practiced Monday and would get the start against Detroit if healthy.
Matt Hasselbeck, filling in for the injured Andrew Luck (kidney) the next few weeks, will look to remain undefeated in Week 12 when the Indianapolis Colts host the Tampa Bay Buccaneers, who rank 13th in pass defense (234.6 ypg).
Connor Barth has been excellent when called upon this season, going 15-for-17 on field goals and 15-for-15 on extra points.
Baldwin continues to hold some value in PPR formats by leading the Seattle passing attack but will need to shake off a low-ankle sprain as Seattle hosts the Steelers in Week 12.
Kirk Cousins came crashing back to Earth in an expected fashion against the Panthers but gets a solid rebound opportunity against a poor New York Giants' pass defense.
Antonio Andrews has averaged 58 yards rushing per game and had a favorable Week 12 matchup against the Oakland Raiders, who rank 23rd in rushing defense (114.7 ypg).
Bailey was asked to make just one field goal in the win over Miami but should benefit from the improved offense now that Tony Romo is back.
Marcus Mariota and the Tennessee Titans, who have scored 14 points or fewer in seven of their 10 games played, get a good matchup in Week 12 when they face the Oakland Raiders, who rank 30th defending the pass (209.5 ypg).
Jameis Winston is coming off a five touchdown, no interception day and goes up against the Colts’ ninth worst defense against opposing quarterbacks.
Leonard Hankerson has found himself as the Falcons’ second option on the outside, but will go against a tough Vikings secondary.
James White scored two touchdowns Monday against the Bills, but had just four touches in all and faces a Denver Broncos defense allowing the fewest yards in the NFL.
Pierre Garcon's streak of being held to 70 yards or under reached nine games in the loss to Carolina.
Isaiah Croweell had negative one total yards on seven touches in Week 10 against the Pittsburgh Steelers, but will try to bounce back in Week 12 against a Baltimore Ravens run defense that allows 97 yards per game on the ground.
Alfred Blue is averaging just 39.2 yards per game, but has a good matchup in Week 12 when the Houston Texans face the New Orleans Saints, the league's 29th-ranked rushing defense (131.2 ypg).
Robert Woods was targeted nine times against the New England Patriots, and will face a Kansas City Chiefs defense allowing 234 passing yards per game this season.
Zach Miller has been more efficient than Martellus Bennett over the last three weeks, and could see additional chances Thursday against the Packers with Bennett dealing with a ribs injury, a defense Bennett scored against in Week 1.
Gabbert performed admirably against the Seahawks in Week 11 and will face another tough test against the Cardinals in Week 12.
Mark Sanchez wasn't good in the loss to Tampa Bay but could pick up another start given Philly's short week, albeit against a Detroit defense that has played well the past two weeks against Green Bay and Oakland.
Ryan Tannehill was held to a season-low 188 passing yards last weekend and faces a New York Jets defense that held him to 198 passing yards when the teams met earlier in 2015.
Marques Colston has been relegated down the depth chart and has more than 50 receiving yards just twice in nine games this season.
Charles Sims’ usage will prevent him from being a top fantasy option, but his pass catching ability should help him against the sub-par Colts defense.
Chris Givens has been targeted 14 times in the past two weeks but only converted six to receptions, and now will have to establish chemistry with new quarterback Matt Schaub, though he does have a good matchup this Monday against a Cleveland Browns pass defense that is 26th in the NFL with 268.5 yards allowed per game and tied for 30th with 21 passing touchdowns allowed.