Palmer overcame some early turnovers and torched the Bengals for 317 yards and four touchdowns and will look to continue his recent hot streak against the 49ers in Week 12.
Derek Carr should rebound from a poor Week 11 performance Sunday against a Titans defense allowing 8.0 yards per pass attempt, fifth-worst in the league.
Eli Manning now has two 300+ yard efforts in his last three games following a 361-yard effort against the Patriots back in Week 10.
Aaron Rodgers has eight touchdowns in his last three games, and faces a Bears defense which he has lit up for 13 scores in his last three games against
Josh McCown has been reinstated as the starting quarterback for the Cleveland Browns, just in time for a match-up with a poor Baltimore Ravens pass defense that he torched for 457 yards and two touchdowns back in Week 5.
Andy Dalton exploded for 315 passing yards and two touchdowns against the Arizona Cardinals on Sunday, and faces another tough test this week against a St. Louis Rams defense that allows 229.4 passing yards per game but has only given up eight touchdowns all season through the air.
Brock Osweiler looked good in his first NFL start last week, but he'll have a tough challenge Sunday against a Patriots defense holding opposition quarterbacks to an 83.9 QB rating, ninth-lowest in the league.
Cam Newton’s been on fire of late, but goes up against a Cowboys defense that’s allowed an average of 225 passing yards per game over the past five weeks.
Kirk Cousins came crashing back to Earth in an expected fashion against the Panthers but gets a solid rebound opportunity against a poor New York Giants' pass defense.
Ben Roethlisberger had the bye week to allow his injured foot to heal, but in Week 12 he has a tough match-up against the Seattle Seahawks and their Legion of Boom secondary, a unit that is second in the NFL with only 207.2 yards per game allowed through the air.
Blake Bortles looks to lead the Jacksonville Jaguars to its third straight win in Week 12 when they face the San Diego Chargers, who rank 17th in pass defense (247.5 ypg).
Sam Bradford missed the game against Tampa Bay but practiced Monday and would get the start against Detroit if healthy.
Wilson's coming off a three-touchdown performance against the 49ers in Week 11 and may be asked to throw more than usual against a stout Pittsburgh run defense in Week 12.
Matthew Stafford has just three touchdown passes in his last three games, but faces an Eagles defense on Thursday that has allowed 20 on the year, the fourth most in the league, five of which came last week against the Tampa Bay Buccaneers.
Marcus Mariota and the Tennessee Titans, who have scored 14 points or fewer in seven of their 10 games played, get a good matchup in Week 12 when they face the Oakland Raiders, who rank 30th defending the pass (209.5 ypg).
Tom Brady has thrown at least one interception in three-straight games, and faces a Denver Broncos defense that is No. 1 in the NFL against the pass this season.
Jameis Winston is coming off a five touchdown, no interception day and goes up against the Colts’ ninth worst defense against opposing quarterbacks.
Tony Romo threw for 227 yards and two touchdowns in his return following a lengthy absence but gets a far tougher test this week against Carolina.
After missing one game due to a concussion, Brian Hoyer will return to the lineup in Week 12 against the league's worst defense, the New Orleans Saints, who allow 424.3 total yards per game.
Matt Hasselbeck, filling in for the injured Andrew Luck (kidney) the next few weeks, will look to remain undefeated in Week 12 when the Indianapolis Colts host the Tampa Bay Buccaneers, who rank 13th in pass defense (234.6 ypg).
Ryan Tannehill was held to a season-low 188 passing yards last weekend and faces a New York Jets defense that held him to 198 passing yards when the teams met earlier in 2015.
Matt Ryan threw three picks last week and goes up against a Vikings defense that’s allowed just one 300-yard passer all season.
Gabbert performed admirably against the Seahawks in Week 11 and will face another tough test against the Cardinals in Week 12.
Tyrod Taylor is nursing a shoulder injury, but will face a mediocre Kansas City passing defense that has allowed 17 touchdowns through the air in 2015.
Teddy Bridgewater is coming off of his second-highest yardage total of the year, but still has only one game with multiple touchdown passes and will face a Falcons secondary that has allowed the sixth fewest touchdowns in the league.
Alex Smith continues to put up poor passing numbers in the run-first Chiefs offense, and Sunday's matchup against a Bills defense that ranks sixth in the league in QB rating allowed at 81.4 isn't likely to change that.
Matt Schaub has taken over as the starting quarterback for the Baltimore Ravens with Joe Flacco done for the season, and his first match-up is against a Cleveland Browns defense that is 26th in the NFL with 268.5 yards allowed per game and tied for 30th with 21 passing touchdowns allowed.
Philip Rivers is coming off his worst game of the season and has few reliable, healthy receiving options, but faces a Jaguars defense Sunday that ranks 25th in passing yards allowed.
Drew Brees is coming off his worst game of the season and is facing a red-hot Texans defense that’s allowed an average of 195 passing yards per game over their past three games with one touchdown allowed and four interceptions.
Jay Cutler failed to throw a touchdown for the first time all season last week, but should have more of his top weapons back Thursday against the Packers, a defense that is allowing 255 passing yards weekly but just 13 touchdowns in 10 games.
Mark Sanchez wasn't good in the loss to Tampa Bay but could pick up another start given Philly's short week, albeit against a Detroit defense that has played well the past two weeks against Green Bay and Oakland.
Ryan Fitzpatrick is banged up, but he will face a Miami Dolphins defense allowing 251 passing yards per game in 2015, which is 20th in the NFL
Zach Mettenberger will back up a healthy Marcus Mariota when the Tennessee Titans face the Oakland Raiders in Week 12.
Keenum didn't fare any better than the demoted Nick Foles in his first game in a starting role for the Rams and will need to go through the league's concussion protocols if he wants to be cleared for a Week 12 matchup against the Bengals.
Brian Hoyer is expected to return from a concussion in Week 12, so T.J. Yates will head back to the bench when the Houston Texans face the New Orleans Saints.
EJ Manuel is not expected to start Sunday's game against the Kansas City Chiefs despite the fact that Tyrod Taylor is banged up.
Foles may be pressed back into duty as quarterback Case Keenum works his way through the league's concussion protocol but a Week 12 matchup against the Bengals isn't a good place to get back on track after being demoted.
Charlie Whitehurst will back up Matt Hasselbeck, who is filling in for Andrew Luck (kidney) the next several weeks, when the Indianapolis Colts host the Tampa Bay Buccaneers in Week 12.