Clay has emerged as Tyrod Taylor's favorite target, and the Bills may have to rely on their passing attack if both LeSean McCoy (hamstring) and Karlos Williams (concussion) are out.
The Cowboys defense has not allowed an opposing tight end to score or catch more than three passes, something that figures to change once Gronkowski and the Patriots leave town in Week 5.
Graham became the first tight end not to score against the Lions in a Week 4 win but he'll look to get back on track against an exploitable Bengals secondary (279.0 passing yards allowed per game) in Week 5.
Delanie Walker will be three weeks removed from a wrist injury in Week 5 when the Tennessee Titans host the Buffalo Bills, who have allowed the third most receptions to opposing tight ends.
The injury to Daniel Fells opens the door for a more expanded role.
Coby Fleener is moving ahead of Dwayne Allen as a target as the Indianapolis Colts enter a Week 5 meeting against the Houston Texans.
Owen Daniels has an excellent chance of extending his touchdown streak to three games Sunday against a Raiders defense that's already allowed six tight end TDs in just four games.
Coming off of a season-high 11 catches and 83 yards, Bennett faces a Chiefs pass defense that has allowed a league-high 11 touchdown passes to date, though none have gone to tight ends.
Heath Miller was held to a single reception for one yard in his first game with Michael Vick calling signals, and will have a chance to bounce back after an extra-long week of practice against a San Diego Chargers defense that is 25th in passing touchdown percentage allowed.
Davis was held out of Week 4 with a knee strain but could take advantage of a Giants defense that is yielding a league-high 316.3 passing yards per game if he's able to return in Week 5.
Ertz will face a shaky New Orleans defense, but he's averaging fewer than five targets per game in a struggling offense.
Travis Kelce was overshadowed by Jeremy Maclin last week, and could have another quiet game Sunday against a weak Bears defense that's been vulnerable against the run but has held opposing tight ends to just one TD in four games.
Even if healthy, Jacob Tamme is not a great option in Sunday's matchup with the Redskins for a Falcons offense where 10.4 percent of receptions have gone to tight ends.
Brandon Myers will look for more targets (three last week) in Sunday's matchup against the forgiving Jags' secondary.
Benjamin Watson continues to insert himself in the offense (3-30-0), but has yet to score a touchdown and faces an Eagles team on Sunday that’s yet to allow one to a tight end this season.
Rodgers is quietly becoming a third or fourth option in one of the league's best passing attacks, having scored twice in four weeks, but faces a Rams pass defense that has allowed only three receiving touchdowns and 235 yards per game.
Marcedes Lewis had his first receptions of the season in Week 4, but there may be fewer targets in Week 5 when the Jacksonville Jaguars face the Tampa Bay Buccaneers, who are susceptible to the run.
Garrett Graham remains an invisible element in the Houston Texans' offense and that doesn't figure to change in Week 5 against the Indianapolis Colts on Thursday.
Reed left Week 4's win with a concussion, so check the health reports in advance of what would be a nice matchup against the Falcons.
Cook continues to be among quarterback Foles' favorite targets but hasn't been able to do much with it as the Rams travel to take on the Packers and their seventh-best passing defense (197.0 yards per game) in Week 5.
Ebron is uncertain to face a Cardinals defense that is allowing only 199 yards passing per game due to a knee injury, making him unlikely to be worth the risk in Week 5.
Fells continues to struggle to make an impact despite regular snaps in a high octane offense as the Caridnals take on a struggling Lions pass defense in Week 5.